Lipid profile of women with premature ovarian failure

Knauff, Erik A. H.; Westerveld, H. E.; Goverde, Angelique J.; Eijkemans, Marinus J.C.; Valkenburg, Olivier; Santbrink, Evert J. P. van; Fauser, Bart C.J.M.; Schouw, Yvonne T. van der

doi:10.1097/gme.0b013e31816b4509

Cited by 82 publications

(57 citation statements)

References 23 publications

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“…Participating hospitals included all eight university hospitals in the Netherlands and six large regional hospitals. Women suspected to suffer from hypergonadotropic oligo-or amenorrhea were systematically evaluated in the outpatient clinic of each individual hospital, as has been described in previous studies from our group (7,12). For the current study, all women visiting the outpatient clinic for POI were identified (n ¼ 378).…”

Section: Patientsmentioning

confidence: 99%

Limited contribution of NR5A1 (SF-1) mutations in women with primary ovarian insufficiency (POI)

Janse

Duran

Kloosterman

et al. 2012

Fertility and Sterility

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Section: Patientsmentioning

confidence: 99%

Limited contribution of NR5A1 (SF-1) mutations in women with primary ovarian insufficiency (POI)

Janse

Duran

Kloosterman

et al. 2012

Fertility and Sterility

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“…Age positively correlates to BMI, waist circumference, body fat, total cholesterol, LDL cholesterol, triglyceride, leptin, CRP, and glucose levels. Physical activity, despite age, is associated with fewer risk factors for chronic diseases like CVD, type 2 diabetes, and obesity (72). Therefore, regular physical activity may be considered an antidote to these risk factors.…”

Section: Dyslipidemiamentioning

confidence: 99%

Cardiovascular risk in menopausal women and prevalent related co-morbid conditions: facing the post-Women's Health Initiative era

Pérez‐López

Chedraui

Gilbert

et al. 2009

Fertility and Sterility

131

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Section: Long-term Effectsmentioning

confidence: 99%

“…This risk is more pronounced in those who have never used estrogens. The increased risk of CVD may be due to direct effects on the endothelium [87], or through alterations to traditional cardiovascular risk factors such as adverse effects on lipid profile [88], reduced insulin sensitivity [89] and metabolic syndrome [90].A recent review of the available evidence has suggested a significant increased risk of stroke associated with POI, with a protective role for estrogen used until the average age of menopause [91]. Additionally, data…”

mentioning

confidence: 99%

Current Concepts in Premature Ovarian Insufficiency

Maclaran

Panay

2015

Womens Health (Lond Engl)

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Premature ovarian insufficiency (POI) is a life-changing diagnosis, with profound physical and psychological consequences. Unfortunately, there are many deficiencies in our understanding of the condition as the underlying etiology and optimum management strategies are poorly understood. Improved awareness of POI and its long-term implications has led to increased research interest in recent years. Current research has allowed a greater understanding of the changing epidemiology in POI, genetic factors in its etiology and randomized controlled trials of hormone therapy are underway to provide evidence for treatment. This article reviews the latest literature on POI to summarize current understanding and future directions. Premature ovarian insufficiency (POI) is a life-changing diagnosis, with profound physical and psychological consequences, affecting approximately one in 100 women by the age of 40 years [1]. Unfortunately, there are many deficiencies in our understanding of the condition as the underlying etiology and optimum management strategies are poorly understood. Furthermore, controversy exists surrounding the terminology and diagnostic criteria, all of which can have a significant impact on the patients' well-being.Improved awareness of POI and its longterm implications has led to increased research interest in recent years. Current research has allowed a greater understanding of the changing epidemiology in POI, genetic factors in its etiology and randomized controlled trials (RCTs) of hormone therapy (HT) are underway to provide evidence for treatment. Here we aim to review the latest literature on POI to summarize current understanding and future directions. TerminologyThere has been a long-standing lack of consensus over the nomenclature of the disorder, with a variety of other terms in use, such as primary ovarian insufficiency, premature ovarian failure, premature menopause and hypergonadotrophic hypogonadism. We use the term premature ovarian insufficiency as it encompasses both spontaneous POI and the increasing number of women who have suffered POI as a result of iatrogenic interventions. The term insufficiency, rather than failure, is thought to more accurately reflect the unpredictable nature of ovarian function in the disorder as intermittent ovarian function, resulting in ovulation and even pregnancy, can occur [2,3]. The use of the term 'premature' refers to the timeline rather than the etiology, that is, ovarian insufficiency which has occurred before 40 years of age from any cause. It is important to note, however, that the condition does not always develop by the same mechanism as the normal menopause, which is due to follicle depletion. For example, some women develop POI due to mutations in the follicle stimulating hormone (FSH) receptor -these women have follicles in the ovary that are unable to function. Another example is steroidogenic cell POI has traditionally been defined as the triad of amenorrhea, elevated gonadotrophins and estrogen deficiency occurring in women under the age...

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Lipid profile of women with premature ovarian failure

Cited by 82 publications

References 23 publications

Limited contribution of NR5A1 (SF-1) mutations in women with primary ovarian insufficiency (POI)

Limited contribution of NR5A1 (SF-1) mutations in women with primary ovarian insufficiency (POI)

Cardiovascular risk in menopausal women and prevalent related co-morbid conditions: facing the post-Women's Health Initiative era

Current Concepts in Premature Ovarian Insufficiency

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