Lipid profile in leukemia and Hodgkin's disease

Naik, Purva P.; Ghadge, M. S.; Raste, A. S.

doi:10.1007/bf02912921

Cited by 24 publications

(33 citation statements)

References 15 publications

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“…In other gynaecologic cancers there was significant decrease in TG, TC, HDL-C and insignificant decrease in LDL-C. HDL-C was decreased in all gynaecologic cancers (Dabrowa et al 2011). Serum TC, HDL-C and LDL-C were reported to be significantly decreased and serum TG significantly elevated in leukaemia and Hodgkin's disease patients (Naik et al, 2006). Study of lung and haematological cancers with lipid profile showed statistically insignificant value for TG and lower values of TC and LDL-C.…”

Section: Discussionmentioning

confidence: 95%

“…Alteration in cholesterol metabolism, increased synthesis of cholesterol, increased accumulation of cholesterol in tumour tissue with decreased serum levels of cholesterol esters are reported. In addition hypocholesterolemia is suggested to be a possible prognostic factor in malignancies (Naik et al, 2006). However, little data is available regarding cervical cancer and lipid parameters.…”

Section: Discussionmentioning

confidence: 99%

“…One study showed that alpha linolenic acid treated cervical and breast cancer cells increase lipid peroxidation and simultaneous decrease nitric oxide release resulting in apoptosis (Gupta and Singh, 2013). Peterson stated that hypercholesterolemia in cancer patients may be because of increased LDL receptor activity (Naik et al, 2006;Singh et al, 2013). Hypolipidemia can also be due to secondary malfunction of lipid metabolism (Singh et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

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Significance of the Plasma Lipid Profile in Cases of Carcinoma of Cervix: A Tertiary Hospital Based Study

Raju

Punnayanapalya²,

Mariyappa³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (8), 3779-3784 IntroductionCervical cancer is one of the leading cancer related death among women worldwide (Satija, 2013). Cervical cancer is the third most common cancer in women worldwide accounting for 9% of all female cancer and 9% death in females due to cervical cancer. Worldwide it is seventh cancer with estimated 530,000 new cases in 2008 accounting for 4% of cancer worldwide. More than 85% of the global burden is seen in developing countries compared to western countries and it accounts for 13% of all female cancers. In India, 134,000 were detected to have cervical cancer, out of which 72,825 women died of cervical cancer in 2008 (Globocan, 2008;Misra et al., 2009). At our institute cervical cancer accounts for about 17.5% of total cancers in females (Kalyani et al., 2010).Lipids are high energy yielding molecules and include fats and oils, waxes, phospholipids, steroids and other related compounds. Fats and oils are made from two kinds

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Significance of the Plasma Lipid Profile in Cases of Carcinoma of Cervix: A Tertiary Hospital Based Study

Raju

Punnayanapalya²,

Mariyappa³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Our results are inconsistent with the study of Naik et al, 2006, which shows that serum TC, HDL-c and LDLc significantly decreased and serum TG significantly elevated in leukemia and Hodgkin's disease patients. Many epidemiological studies have shown increased risk of death in cancer patients with low serum TC levels [15]. The elevation in lipid levels may be due to the reason that lipid maintains cell integrity and functionality of cell.…”

Section: Discussionmentioning

confidence: 99%

Association between Lipid Profile and Ovarian Cancer in women of North India

Tiwari¹,

Verma²,

Sankhwar³

et al. 2015

Int Jour of Biomed Res

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Objective: The aim of this study was to compare serum lipid profiles: total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c) and very low density lipoprotein cholesterol (VLDL-c) and lipid ratio among ovarian cancer (OC) patients and healthy controls. Methods: Total 300 subjects were enrolled in this study. Study group comprised of 150 clinically and histologically proved cases of ovarian carcinoma and 150 healthy women recruited as a control group. Plasma levels of TC, TG and HDL were determined using a commercially available kit and a semi-automated analyzer. LDL and VLDL were calculated by Friedewald's formula. Results: In our study, we found the higher level of mean serum cholesterol, TGs, LDL-c and VLDL in OC patients as compared to the controls. The HDL level is higher in controls as compared to study group. TGs, HDL-c VLDL were found highly significant in OC patients as compared to controls. The Ratio of TC/HDL, LDL/HDL, HDL/LDL was also found significantly higher in OC patients as compared to controls. Conclusions:The results of the present study shows that plasma lipid levels, except HDL-cholesterol, are increase in OC. As there is an alteration in the plasma lipid profile during gynecologic cancers, it may be helpful for diagnosis of the disease. Further studies needed to investigate, to group important factors including, cancer stages and type of cancer, parity, and menopausal status that may affect lipid profiles in OC patients along with an investigation of new lipid profiles to clarify most lipid factors that may involve in OC development are needed.

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“…Most of the previous reports have demonstrated a decrease in total cholesterol (TC) [1][2][3][4][5][6] and various lipoprotein subfractions particularly, high-density lipoprotein cholesterol (HDL-C) [1][2][3][4][5][6][7][8], whereas an increase in the serum triglyceride (TG) concentrations of the leukemia patients is also a frequently observed phenomenon [1,3,4,[6][7][8]. Nevertheless there are several inconsistencies in the previous reports [9].…”

Section: Introductionmentioning

confidence: 90%