Lipid profile in congenital adrenal hyperplasia

Botero, Diego; Arango, Ana María Arboleda; Danon, Marco; Lifshitz, Fima

doi:10.1053/meta.2000.6261

Cited by 25 publications

(18 citation statements)

References 18 publications

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“…In contrast, our study group was treated with glucocorticoid replacement since their first months of life. Studies on children and adolescents with CAH had small number of patients and, different from our study, their patients showed a wide age range and pubertal status, making comparisons with our group difficult (15,18).…”

Section: Discussioncontrasting

confidence: 77%

“…obesity, dyslipidemia, hypertension, and excess glucocorticoid (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Unlike the great majority of published studies on patients with CAH, we did not find a high propensity for obesity or excess weight (8)(9)(10)(11)(12)(14)(15)(18)(19). We believe that this finding was due to the rigorous clinical management of our patients since diagnosis; they were followed up by the same doctor, and they received guidance that emphasized adequate nutrition and adherence to medication.…”

Section: Discussionmentioning

confidence: 52%

“…Adult patients with classical CAH have a higher frequency of obesity, visceral adiposity, hyperinsulinism, insulin resistance and hyperandrogenism, compared with normal individuals (1,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). However, it is not clear whether hyperinsulism is due to increased obesity in these patients, or if it is inherent to the disorder itself.…”

Section: Introductionmentioning

confidence: 99%

“…However, it is not clear whether hyperinsulism is due to increased obesity in these patients, or if it is inherent to the disorder itself. Adrenomedullary dysfunction and intermittent hypercortisolism are linked to these abnormalities, which predispose these patients to a higher risk of metabolic syndrome and atherosclerosis (1,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

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Metabolic evaluation of young women with congenital adrenal hyperplasia

Schnaider-Rezek

Lemos-Marini

Baptista

et al. 2011

Arq Bras Endocrinol Metab

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Objective: To evaluate insulin resistance and lipid profile in women with congenital adrenal hyperplasia (CAH) caused by classical 21-hydroxylase deficiency (21OHD), and their association with body mass index (BMI) and corticosteroid dosage. Subjects and methods: We assessed BMI, waist circumference, current glucocorticoid dosage, glucose, insulin and lipid profile in eighteen young women (mean ± SD, 19.3 ± 3.0 years) with 21OHD CAH. Results: BMI was normal in 12 patients, 5 of them were overweight, and 1 was obese. Waist circumference was high in 7 patients. Fasting insulin and HOMA-IR were elevated in seven and eight patients, respectively. Total cholesterol and triglycerides were high in only two patients, and HDL-cholesterol was low in four. Insulin resistance was not associated with BMI, waist circumference or glucocorticoid dose. Conclusions: Young women with 21OHD CAH had infrequent dyslipidemia, but had a higher prevalence of insulin resistance and central obesity, that were independent of BMI or corticosteroid dosage. Arq Bras Endocrinol Metab. 2011;55(8):646-52

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Section: Discussioncontrasting

confidence: 77%

Section: Discussionmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Metabolic evaluation of young women with congenital adrenal hyperplasia

Schnaider-Rezek

Lemos-Marini

Baptista

et al. 2011

Arq Bras Endocrinol Metab

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“…Possible metabolic consequences of increased body fat include dyslipidaemia and insulin resistance. Only one study in CAH children treated with prednisone showed elevated triglycerides [46], whereas other studies performed in adults and children demonstrated normal cholesterol, triglycerides as well as LDL and HDL cholesterol [38,39,47]. Normal lipid profiles were also found in 50 untreated females with non-classic CAH [48].…”

Section: Cardiovascular and Metabolic Healthmentioning

confidence: 99%

Health Problems in Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency

Reisch

Arlt

Krone³

2011

Horm Res Paediatr

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Following the introduction of life-saving glucocorticoid replacement 60 years ago, congenital adrenal hyperplasia (CAH) has evolved from being perceived as a paediatric disorder to being recognized as a lifelong, chronic condition affecting patients of all age groups. Increasing evidence suggests that patients with CAH have an increased risk to develop health problems during adult life, with signs and symptoms of forerunner conditions of adult disease already emerging during the time of paediatric care. Transition of paediatric CAH patients to medical care in the adult setting is an important step to ensure optimal lifelong treatment, aiming to achieve good health and normal life expectancy and quality of life. Thus, primary and secondary prevention of health problems has to become a task of increasing importance for those involved in the care of CAH patients throughout their life.

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Fat Distribution and Lipid Profile of Young Adults with Congenital Adrenal Hyperplasia Due to 21‐Hydroxylase Enzyme Deficiency

Borges

Oliveira

Lemos-Marini

et al. 2020

Lipids

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We aimed to compare detailed fat distribution and lipid profile between young adults with congenital adrenal hyperplasia due to 21‐hydroxylase enzyme deficiency and a control group. We also verified independent associations of treatment duration and daily hydrocortisone dose equivalent (HDE) with lipid profile within patients. This case–control study included 23 patients (7 male and 16 female) matched by an age range of young adults (18–31 years) with 20 control subjects (8 male and 12 female). Dual energy X‐ray absorptiometry was used to measure the fat distribution. Male patients demonstrated elevated indices of fat mass for total (7.7 ± 2.1 vs. 4.5 ± 1.3 kg/m2, p = 0.003), trunk (4.0 ± 1.2 vs. 2.2 ± 0.8 kg/m2, p = 0.005), android (0.63 ± 0.24 vs. 0.32 ± 0.15 kg/m2, p = 0.008), gynoid (1.34 ± 0.43 vs. 0.74 ± 0.24 kg/m2, p = 0.005), arm (0.65 ± 0.16 vs. 0.39 ± 0.10 kg/m2, p = 0.009), and leg regions (2.7 ± 0.8 vs. 1.6 ± 0.4 kg/m2, p = 0.005) than the control group, but not in females. However, female patients demonstrated elevated ratio of low‐density lipoprotein cholesterol to high‐density lipoprotein cholesterol (1.90 ± 0.46 vs. 1.39 ± 0.47, p = 0.009) than the control group, but not in males. Total fat mass was inversely correlated with total testosterone (r = −0.64, p = 0.014) and positively correlated with leptin in males (r = 0.75, p = 0.002). An elevated daily HDE (β = 0.43, p = 0.038 and β = 0.47, p = 0.033) and trunk to total fat mass ratio (β = 0.46, p = 0.025, and β = 0.45, p = 0.037) were independently correlated with impaired lipid profile markers. Although there is no altered lipid profile, male patients demonstrated an increased fat distribution. However, female patients presented with an impaired lipid profile marker but demonstrated close values of normal fat distribution. Interestingly, the dose of glucocorticoid therapy can have some role in the lipid mechanisms.

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Lipid profile in congenital adrenal hyperplasia

Cited by 25 publications

References 18 publications

Metabolic evaluation of young women with congenital adrenal hyperplasia

Metabolic evaluation of young women with congenital adrenal hyperplasia

Health Problems in Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency

Fat Distribution and Lipid Profile of Young Adults with Congenital Adrenal Hyperplasia Due to 21‐Hydroxylase Enzyme Deficiency

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