Lipid Profile and Metabolic Syndrome Status in Patients with Oral Lichen Planus, Oral Lichenoid Reaction and Healthy Individuals Attending a Dental College in Northern India - A Descriptive Study

Abstract

There may be an association between chronic inflammation and dyslipidemia that increases the risk for cardiovascular disease. OLP and OLR patients have increased serum cholesterol and LDL-C when compared to normal adults. Further research on lipid levels in OLR are required to establish the findings of this study.

Lichen planus and dyslipidemia: a systematic review and meta‐analysis of observational studies

“…6,9,10,16–18 The authors also reported a comparatively lower mean HDL‐C level of 32.2 ± 6.4 mg/dl . The HDL‐C levels in patients with LP reported by other studies ranged from 42.4 ± 0.21 to 59.8 ± 14.6 mg/dl . Mean total cholesterol and LDL‐C levels in this study were also relatively higher than those from other studies.…”

“…Table 1 summa-rizes the study population characteristics in each study. 6,9,10,[16][17][18][19] All but one study identified cases of LP through histological confirmation. Three studies were deemed to be high quality based on the aforementioned validated five-point scale.…”

The Association of Cutaneous Lichen Planus and Metabolic Syndrome: A Case-Control Study

“…While studies on the association of level of prevalence of MS in mucosal than in cutaneous LP as well as in patients with longer disease duration. Other investigators have shown that there is an association between oral LP and oral lichenoid reaction and MS (20). It should also be mentioned that various clinical presentations of LP are in association with different risks of MS.…”

“…AriasSantiago et al reported a significant prevalence of serum lipid derangement in all parameters including TG, LDL-C, HDL-C, Chol, Total cholesterol/HDL-C, and LDL-C/HDL-C ratios among LP patients in comparison with controls (21). Oral LP and oral lichenoid reaction have also been associated with significant dyslipidemia (20). Other authors, however, did not find abnormal lipid levels in LP (18,35).…”

“…However, there is much research available that denies the above-mentioned association (11)(12)(13). Recent evidence suggests that LP can be associated with dyslipidemia and other components of MS (14)(15)(16)(17)(18)(19)(20)(21). The early investigation and diagnosis of MS in this population of patients will help control the risk factors and prevent the serious morbidity and mortality of cardiovascular events.…”