Lipid profile and atherogenic indices in patients with stable chronic obstructive pulmonary disease

Markelić, Ivona; Hlapčić, Iva; Rogić, Dunja; Rako, Ivana; Samaržija, Miroslav; Popović‐Grle, Sanja; Rumora, Lada; Dugac, Andrea Vukić

doi:10.1016/j.numecd.2020.07.039

Cited by 16 publications

(15 citation statements)

References 40 publications

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“… 36 , 37 HDL deficiency resulted in peripheral leukocytosis, including blood eosinophilia, 38 and a 1 mmol/L HDL cholesterol lowering was reported to be correlated with 14.8% higher eosinophils. 34 Given the imbalance in lipid profile in COPD implied by previous studies, 39–41 it is imperative to explore whether the change in HDL level plays a role in eosinophilic COPD, and whether treatment for lower HDL in COPD is beneficial to reduce eosinophil-predominant exacerbation.…”

Section: Discussionmentioning

confidence: 99%

Clinical Predictors of High Blood Eosinophils in Chronic Obstructive Pulmonary Disease

Yang

et al. 2021

COPD

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Purpose Elevated blood eosinophils have been implicated in chronic obstructive pulmonary disease (COPD) progression and exacerbation. We aim to investigate clinical predictors of high blood eosinophils in a Chinese COPD cohort. Patients and Methods We conducted a retrospective cohort study in Sichuan province, a Southwest province with high prevalence of COPD in China. All patients in this cohort were extracted from the Chinese Pulmonary Health study, a large cross-sectional study on COPD epidemiology in China. Demographics, personal and family history, living condition, spirometry and blood eosinophil counts were obtained. Univariate and multiple linear regression analyses were performed to determine predictors of high blood eosinophils. Results A total of 375 COPD patients were included in this cohort. The median absolute blood eosinophil count was 138.8 cells/μL, and the prevalence of COPD with high blood eosinophils was 66.7% and 14.7% when using the thresholds of 100 cells/μL and 300 cells/μL, respectively. Univariate analyses indicated that male gender, lower body mass index, high-density lipoprotein (HDL), lower family income, raising pets and biomass use were significantly associated with high blood eosinophils (p < 0.05). Multiple linear regression model further revealed male gender (unstandardized coefficient (B)=66.125, 95% confidence intervals (CI) 16.350 to 115.900, p=0.009), age (B=2.819, 95% CI 0.639 to 5.000, p=0.012) predicted high blood eosinophil level, whereas HDL (B=−64.682, 95% CI −123.451 to −5.914, p=0.031) was a negative predictor for high blood eosinophils. Conclusion This retrospective cohort study suggests male gender, oldness and lower HDL could be clinical predictors of high blood eosinophils in Chinese COPD patients.

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Section: Discussionmentioning

confidence: 99%

Clinical Predictors of High Blood Eosinophils in Chronic Obstructive Pulmonary Disease

Yang

et al. 2021

COPD

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“…Although we had adjusted some confounders, whether the association between moderately increased apoB levels and decreased mortality is causal is still an unresolved question to the ndings. Researchers found that, compared to healthy individuals, chronic obstructive pulmonary disease (COPD) patients had higher HDL-C and lower TG, TC, and LDL-C, while those lipid parameters varied reversely in COPD patients with cardiovascular diseases (31). Other disease conditions, including debilitation and wasting in liver diseases, would result in less secretion of lipoproteins (32).…”

Section: Discussionmentioning

confidence: 99%

U-shaped Association Between Apolipoprotein B and All-Cause Mortality: Results from the National Health and Nutrition Examination Surveys

Yan¹,

Liu²,

Huang³

et al. 2021

Preprint

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BackgroundApolipoprotein B (apoB), a significant component directly reflecting the number of atherogenic lipoprotein particles, gradually becomes a more conducive indicator to control blood lipids. However, epidemiological evidence on its relationship with mortality is limited, especially with all-cause mortality. MethodsParticipants from the National Health and Nutrition Examination Survey during 2007-2014 were grouped according to the apoB quartiles (15-76, 77-92, 93-110, 111-345mg/dL). We performed Cox proportional hazards models and Kaplan-Meier survival curves to evaluate the relationships of apoB with all-cause and cardiovascular mortality. Restricted cubic spline and piecewise linear regression were performed to detect their non-linear relationships. ResultsIn general, we enrolled 10375 participants among United States adults (mean age 46.3 ± 16.9, 47.88% men). On average, participants were followed up for 69.2 months, among whom 533 (5.14%) and 91 (0.88%) deaths were observed due to all -causes and cardiovascular diseases, respectively. After adjusting for confounders, apoB was independently associated with an elevated risk of cardiovascular death (hazard ratio [HR], 1.13; 95% confidence interval [CI], 1.03-1.24). However, in the third quartile of apoB, the risk of all-cause death decreased significantly (HR, 0.71; 95% CI, 0.56-0.91). Moreover, the non-linear relationship between apoB and all-cause death demonstrated an increased risk at both low and high level apoB concentrations, divided by the threshold point of 108 mg/dl. ConclusionElevated apoB was significantly associated with an increased risk for cardiovascular mortality, while its association with all-cause mortality was non-linear correlated, with an increased risk at both low and high apoB levels.

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“…Non-traditional lipid parameters were calculated as follows: non-HDL-C was defined as subtracting serum HDL-C concentration from TC. Atherogenic coefficient was calculated as non-HDL-C/HDL-C; AIP was calculated as log 10 (TG/HDL-C); CRI-I was calculated as TC/HDL-C; and CRI-II was calculated as LDL-C/HDL-C ( 10 , 16 , 17 ).…”

Section: Methodsmentioning

confidence: 99%

Non-traditional Lipid Parameters as Potential Predictors of Asymptomatic Intracranial Arterial Stenosis

Guo

Wang

et al. 2021

Front. Neurol.

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Background: Intracranial arterial stenosis (ICAS) is a common cause of stroke. Identifying effective predictors of ICAS that could be easily obtained in clinical practice is important. The predictive values of serum individual lipid parameters have been well-established. In recent years, several non-traditional lipid parameters demonstrated greater predictive values for cardiovascular disease and ischemic stroke than traditional individual lipid parameters. However, their effects on asymptomatic ICAS (aICAS) are less clear. Therefore, we sought to observe the effects of non-traditional lipid parameters on aICAS.Methods: We enrolled 5,314 participants from the Asymptomatic Polyvascular Abnormalities in Community study. Asymptomatic ICAS was detected by transcranial Doppler ultrasonography (TCD). Non-traditional lipid parameters, including non-high-density lipoprotein cholesterol (non-HDL-C), the triglycerides/high-density lipoprotein cholesterol ratio (TG/HDL-C), atherogenic coefficient (AC), atherogenic index of plasma, and Castelli's risk index (CRI) were measured. We used multivariable logistic analysis to assess the association of different lipid parameters with aICAS; a trend test and subgroup analyses were also performed.Results: In total, 695 of 5,314 participants had aICAS in this study. For the comparison of the highest to the lowest tertile, the multivariable-adjusted odds ratios (ORs) (95% CIs) were 1.78 (1.39–2.27) (p trend < 0.001) for non-HDL-C, 1.48 (1.18–1.85) (p trend = 0.004) for the AC, 1.48 (1.18–1.85) (p trend = 0.004) for CRI-I, and 1.34 (1.09–1.66) (p trend = 0.032) for CRI-II. Subgroup analyses showed significant interactions between the AC, CRI-I, and diabetes.Conclusions: This large community-based study showed that non-HDL-C, AC, CRI-I, and CRI-II were significantly associated with increased prevalence of aICAS.

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Lipid profile and atherogenic indices in patients with stable chronic obstructive pulmonary disease

Cited by 16 publications

References 40 publications

Clinical Predictors of High Blood Eosinophils in Chronic Obstructive Pulmonary Disease

Clinical Predictors of High Blood Eosinophils in Chronic Obstructive Pulmonary Disease

U-shaped Association Between Apolipoprotein B and All-Cause Mortality: Results from the National Health and Nutrition Examination Surveys

Non-traditional Lipid Parameters as Potential Predictors of Asymptomatic Intracranial Arterial Stenosis

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