Clinical Predictors of High Blood Eosinophils in Chronic Obstructive Pulmonary Disease

Abstract

Purpose Elevated blood eosinophils have been implicated in chronic obstructive pulmonary disease (COPD) progression and exacerbation. We aim to investigate clinical predictors of high blood eosinophils in a Chinese COPD cohort. Patients and Methods We conducted a retrospective cohort study in Sichuan province, a Southwest province with high prevalence of COPD in China. All patients in this cohort were extracted from the Chinese Pulmonary Health study, a large cross-sectional study on COPD epidemiology in China. Demographics, personal and family history, living condition, spirometry and blood eosinophil counts were obtained. Univariate and multiple linear regression analyses were performed to determine predictors of high blood eosinophils. Results A total of 375 COPD patients were included in this cohort. The median absolute blood eosinophil count was 138.8 cells/μL, and the prevalence of COPD with high blood eosinophils was 66.7% and 14.7% when using the thresholds of 100 cells/μL and 300 cells/μL, respectively. Univariate analyses indicated that male gender, lower body mass index, high-density lipoprotein (HDL), lower family income, raising pets and biomass use were significantly associated with high blood eosinophils (p < 0.05). Multiple linear regression model further revealed male gender (unstandardized coefficient (B)=66.125, 95% confidence intervals (CI) 16.350 to 115.900, p=0.009), age (B=2.819, 95% CI 0.639 to 5.000, p=0.012) predicted high blood eosinophil level, whereas HDL (B=−64.682, 95% CI −123.451 to −5.914, p=0.031) was a negative predictor for high blood eosinophils. Conclusion This retrospective cohort study suggests male gender, oldness and lower HDL could be clinical predictors of high blood eosinophils in Chinese COPD patients.

Blood Eosinophil Count and Its Determinants in a Chinese Population-Based Cohort

“…Association between age and blood EOS has been indicated. Children and adolescence tended to have higher blood EOS [23, 37, 38], and in our previous work of participants aged ≥40 years, oldness was the predictor of high blood EOS [39]. Çolak et al [40] also found age (per 10 years higher) was correlated with blood EOS ≥300 cells/μL.…”

Research progress of Chinese herbal medicines and classic prescriptions in the treatment of COPD based on the TCM theory and medicinal characteristics

“…Lung, spleen, and kidney deficiency, especially kidney deficiency, is the primary pathological mechanism in stable COPD. [167] Although Jingui Shen Qi pills combined with Western medicine can effectively relieve the symptoms, inhibit the short-term deterioration of the lung function, and improve exercise endurance and quality of life of the elderly patients with stable COPD and kidney-yang deficiency, it shows no significant effect on lung function indicators. [168]…”

Body mass index affects the association between plasma lipids and peripheral eosinophils in a general chinese population: a cross-sectional survey

“…High low-density lipoprotein-cholesterol (LDL-C) and triglyceride (TG) levels are associated with high rates of asthma and aeroallergen sensitisation [ 6 ]. Low high-density lipoprotein-cholesterol (HDL-C) levels clinically predict high peripheral eosinophil count in Chinese patients with chronic obstructive pulmonary disease [ 7 ]. Patients with allergic rhinitis also present with dyslipidaemia, which aggravate the symptoms of allergic rhinitis [ 8 ] and increase the risk of chronic rhinosinusitis [ 9 ].…”