LIPID PEROXIDES, GLUTATHIONE, Γ-Glutamylcysteine SYNTHETASE AND Γ-Glutamyltranspeptidase ACTIVITIES IN SEVERAL TISSUES OF RATS FOLLOWING WATER-IMMERSION STRESS

Alptekin, Nilgün Özlem; Seçkin, Şule; Doğru‐Abbasoğlu, Semra; Yelkenci, Fuat; Koçak‐Toker, Necla; Toker, Gülçin; Uysal, Müjdat

doi:10.1006/phrs.1996.0084

Cited by 42 publications

(24 citation statements)

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“…Accordingly, a conspicuous increase of CAT and GSH-Px activities recorded here from day·7 of cold acclimation could be attributed to increased ␤-oxidation of fatty acids and, connected to that, increased H 2 O 2 production. These data are in line with studies on various tissues that reported increases in CAT and GSH-Px activity during cold exposure, as a response to increased peroxidative pressure (Alptekin et al, 1996;Buzadzic et al, 1997;Selman et al, 2000).…”

Section: Discussionsupporting

confidence: 91%

Antioxidative defence alterations in skeletal muscle during prolonged acclimation to cold: role ofl-arginine/NO-producing pathway

Petrović

Buzadžić

Korać

et al. 2008

Journal of Experimental Biology

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SUMMARYEarly in cold acclimation (1-7·days), heat is produced by shivering, while late in cold acclimation (12-45·days), skeletal muscle contributes to thermogenesis by tissue metabolism other than contractions. Given that both thermogenic phases augment skeletal muscle aerobic power and reactive species production, we aimed in this study to examine possible changes in skeletal muscle antioxidative defence (AD) during early and late cold acclimation with special emphasis on the influence of the Larginine/nitric oxide (NO)-producing pathway on the modulation of AD in this tissue. Adult Mill Hill hybrid hooded rat males were divided into two main groups: a control group, which was kept at room temperature (22±1°C), and a group maintained at 4±1°C for 45·days. The cold-acclimated group was divided into three subgroups: untreated, L-arginine treated and N -nitro-L-arginine methyl ester (L-NAME) treated. The AD parameters were determined in the gastrocnemius muscle on day 1, 3, 7, 12, 21 and 45 of cold acclimation. The results showed an improvement of skeletal muscle AD in both early and late cold acclimation. Clear phasedependent changes were seen only in copper, zinc superoxide dismutase activity, which was increased in early cold acclimation but returned to the control level in late acclimation. In contrast, there were no phase-dependent changes in manganese superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione S-transferase, the activities of which were increased during the whole cold exposure, indicating their engagement in both thermogenic phases. L-Arginine in early cold acclimation accelerated the cold-induced AD response, while in the late phase it sustained increases achieved in the early period. L-NAME affected both early and late acclimation through attenuation and a decrease in the AD response. These data strongly suggest the involvement of the L-arginine/NO pathway in the modulation of skeletal muscle AD.

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Section: Discussionsupporting

confidence: 91%

Antioxidative defence alterations in skeletal muscle during prolonged acclimation to cold: role ofl-arginine/NO-producing pathway

Petrović

Buzadžić

Korać

et al. 2008

Journal of Experimental Biology

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“…There are reports that the hepatic and gastric concentrations of GSH are decreased in WIRS rats 22,23 and that the hepatic GSH concentration is increased in mice administered ellagic acid. 24 Although the hepatic GSH concentration was decreased by WIRS, ingestion of GCE showed similar concentrations of GSH to those without WIRS.…”

Section: Antioxidant Enzymatic Activitiesmentioning

confidence: 99%

Mechanism of preventive action of Viburnum dilatatum Thunb (gamazumi) crude extract on oxidative damage in rats subjected to stress

Iwai

Onodera²,

Matsue

2003

J Sci Food Agric

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The fruit of Viburnum dilatatum Thunb (gamazumi) has been shown to prevent oxidative injury induced by water immersion restraint stress (WIRS) in rats. In this study the effect of gamazumi crude extract (GCE) on antioxidant enzymatic activities in the plasma, liver and stomach of rats with WIRS was investigated to elucidate the mechanism of prevention of oxidative injury. Ulcer formation and lipid peroxidation were inhibited in rats supplied GCE for 2 weeks in comparison with rats supplied water. Although the activities of plasma, hepatic and gastric antioxidant enzymes in rats given water were decreased by WIRS, only slight changes were observed in rats given GCE. There was no difference in enzymatic activities between the water and GCE groups not subjected to WIRS. Furthermore, ferrous ascorbate-induced oxidation in hepatic homogenate from rats given GCE was inhibited. These results suggest that ingestion of GCE does not induce antioxidant enzymes and that the absorbed antioxidant components of GCE have a direct effect on oxidative injury in the body.

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“…Reports on the effects of short-and long-term cold exposure on g-GCS and g-GT activities are lacking. However, it has been reported that hepatic GSH level is decreased, whereas g-GCS activity is increased and g-GT activity is not modified by water-immersion restraint, suggesting that GSH depletion is not due to depressed synthesis or increased breakdown following water-immersion restraint stress (Alptekin et al, 1996). Conversely, it is likely that liver GSH content is reduced because of increased utilization in both conjugation reactions favored by increased activity of GST and redox reactions by which lipid peroxidation products are eliminated.…”

Section: Antioxidant System Cold Exposurementioning

confidence: 98%

Oxidative stress in cold-induced hyperthyroid state

Venditti

Stefano

Meo

2010

Journal of Experimental Biology

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SUMMARYExposure of homeothermic animals to low environmental temperature is associated with oxidative stress in several body tissues. Because cold exposure induces a condition of functional hyperthyroidism, the observation that tissue oxidative stress also happens in experimental hyperthyroidism, induced by 3,5,3Ј-triiodothyronine (T 3 ) treatment, suggests that this hormone is responsible for the oxidative damage found in tissues from cold-exposed animals. Examination of T 3 -responsive tissues, such as brown adipose tissue (BAT) and liver, shows that changes in factors favoring oxidative modifications are similar in experimental and functional hyperthyroidism. However, differences are also apparent, likely due to the action of physiological regulators, such as noradrenaline and thyroxine, whose levels are different in cold-exposed and T 3 -treated animals. To date, there is evidence that biochemical changes underlying the thermogenic response to cold as well as those leading to oxidative stress require a synergism between T 3 -and noradrenaline-generated signals. Conversely, available results suggest that thyroxine (T 4 ) supplies a direct contribution to cold-induced BAT oxidative damage, but contributes to the liver response only as a T 3 precursor.

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LIPID PEROXIDES, GLUTATHIONE, Γ-Glutamylcysteine SYNTHETASE AND Γ-Glutamyltranspeptidase ACTIVITIES IN SEVERAL TISSUES OF RATS FOLLOWING WATER-IMMERSION STRESS

Cited by 42 publications

References 0 publications

Antioxidative defence alterations in skeletal muscle during prolonged acclimation to cold: role ofl-arginine/NO-producing pathway

Antioxidative defence alterations in skeletal muscle during prolonged acclimation to cold: role ofl-arginine/NO-producing pathway

Mechanism of preventive action of Viburnum dilatatum Thunb (gamazumi) crude extract on oxidative damage in rats subjected to stress

Oxidative stress in cold-induced hyperthyroid state

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