Lipid peroxidation, Superoxide dismutase and catalase co-relation in pulmonary and extra pulmonary tuberculosis

Dalvi, Shubhangi M.; Patil, Vinayak W.; Ramraje, Nagsen N.; Phadtare, Jaising Marutrao

doi:10.5530/ax.2012.4.1

Cited by 5 publications

(3 citation statements)

References 29 publications

(34 reference statements)

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“…This is in agreement with a previous report 25 but is in contrast with two other studies. 26,27 The reduction of NO observed in the present study is indicative of reduced intracellular killing of Mtb and innate cellular immunosuppression in patients with TB, which may account partly for the continuous persistence of Mtb in macrophages and neutrophils. NO is produced by converting arginine, an amino acid, into citrulline using inducible nitric oxide synthase in phagocytes.…”

Section: Discussionmentioning

confidence: 52%

Innate Cellular Immunity in Newly Diagnosed Pulmonary Tuberculosis Patients and During Chemotherapy

Edem

Arinola

2016

Annals of Global Health

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The intracellular killing aspect of innate cellular immunity is deficient in patients with TB, especially 2 to 4 months after commencement of treatment. Therefore, measures (eg, arginine supplementation) to improve intracellular killing in these patients is advocated. Moreover, %LM assay with Bacillus Calmette-Guérin vaccine as an antigen may be used to differentiate those newly diagnosed patients from those on anti-TB chemotherapy.

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Section: Discussionmentioning

confidence: 52%

Innate Cellular Immunity in Newly Diagnosed Pulmonary Tuberculosis Patients and During Chemotherapy

Edem

Arinola

2016

Annals of Global Health

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“…Several previous studies have found that SOD levels were significantly lower in tuberculosis patients than the control group. The percentage of SOD inhibition in tuberculosis patients was lower than that of the healthy subjects [3], [4]. Other previous studies also showed that the SOD levels in the group of diabetic patients were lower than the group of healthy subjects [24], [25].…”

Section: Discussionmentioning

confidence: 99%

“…Antioxidants, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and others, can decrease this effect. However, previous studies showed that the activity or levels of SOD decreased in tuberculosis patients [3], [4].…”

Section: Introductionmentioning

confidence: 99%

Superoxide Dismutase Levels and Polymorphism (Ala16val) In Tuberculosis Patients with Diabetes Mellitus in Medan City

Sari

Daulay

Wahyuni

2019

Open Access Maced J Med Sci

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BACKGROUND: Infectious diseases and metabolic disorders would result in oxidative stress in cells. Superoxide dismutase (SOD) is an antioxidant present inside cells that acts against oxidative stress. SOD gene polymorphism can affect the activity and levels of SOD. AIM: This study aimed to analyse SOD levels and polymorphism of gene (ala16val) that regulated SOD in tuberculosis patients with diabetes mellitus in Medan city. METHODS: A total of 40 tuberculosis patients with diabetes mellitus and 40 healthy subjects participated in the study. The levels of SOD were measured using enzyme-linked immunosorbent assay (ELISA). Analysis of SOD gene polymorphism (ala16val) was done using polymerase chain reaction-restriction fragment lengths polymorphisms (PCR-RFLP) with BsaW1 as the restriction enzyme. The statistical significance was determined using the Mann Whitney test, Fisher's exact test, and Kruskal Wallis test (p < 0.05). RESULTS: The SOD levels of tuberculosis patients with diabetes mellitus were lower than those of the healthy subjects (102.474 ± 36.07 U/L vs 294.543 ± 58.75 U/L, p < 0.05). Patients of tuberculosis with diabetes mellitus tend to have more value/Val genotypes than the healthy group (57.5% vs 50%, p > 0.05). There was no association between SOD levels and SOD gene polymorphism (ala16val) in tuberculosis patients with diabetes mellitus. CONCLUSION: In this study, there was an association between the levels of SOD and tuberculosis patients with diabetes mellitus, but not for the SOD gene polymorphism (ala16val). The SOD gene polymorphism (ala16val) was not the key role to influence the SOD levels in tuberculosis patients with diabetes mellitus in Medan city.

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Gene expression, levels and polymorphism (Ala16Val) of mitochondrial superoxide dismutase in tuberculosis patients of Rajasthan

Gauba

Gupta

Shekhawat

et al. 2023

Microbes and Infection

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Lipid peroxidation, Superoxide dismutase and catalase co-relation in pulmonary and extra pulmonary tuberculosis

Cited by 5 publications

References 29 publications

Innate Cellular Immunity in Newly Diagnosed Pulmonary Tuberculosis Patients and During Chemotherapy

Innate Cellular Immunity in Newly Diagnosed Pulmonary Tuberculosis Patients and During Chemotherapy

Superoxide Dismutase Levels and Polymorphism (Ala16val) In Tuberculosis Patients with Diabetes Mellitus in Medan City

Gene expression, levels and polymorphism (Ala16Val) of mitochondrial superoxide dismutase in tuberculosis patients of Rajasthan

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