Lipid peroxidation in hippocampus early and late after status epilepticus induced by pilocarpine or kainic acid in Wistar rats

The interactions between the cholinergic and catecholaminergic systems - focusing on memory and oxidative stress

“…Moreover, the use of pergolide in association with L-DOPA in the treatment of Parkinson's disease has shown the powerful antioxidant effect of this combination as compared with the administration of L-DOPA alone [17,18]. When it comes to pilocarpine (its effect on oxidative stress has been studied mostly in experimental models of epilepsy), it was observed an increase of specific activity of catalase in the hippocampus, prefrontal cortex, and striatum [19,20] and lowering the level of malondialdehyde [21]. Clonidine has been found to exert antioxidant effects as demonstrated in various experimental situations, such as some models of addiction to cocaine [22] or hyperglycemia [23] in which the administration of clonidine improved the oxidative stress status.…”

Antioxidant Treatments: Effect on Behaviour, Histopathological and Oxidative Stress in Epilepsy Model

“…Status epilepticus induces ROS production by protein oxidation measured by tyrosine nitration (Rong et al, 1999). It can also be determined by both the end-product of lipid peroxidation, malondialdehyde (MDA) levels (Bruce and Baudry, 1995), and the effectiveness of the antioxidant enzymatic responses (Dal-Pizzol et al, 2000). The hippocampus is the most affected area by pilocarpine-induced seizures.…”

Antioxidant mechanisms of iso-6-cassine in suppressing seizures induced by pilocarpine

“…Considering that studies have demonstrated that status epilepticus induced by pilocarpine is followed by changes in the level of oxidative stress Dal-Pizzol et al, 2000), and that ISO abolished seizures in this model, the effect of ISO on oxidative stress caused by pilocarpine was investigated. Subsequently to the seizure episode induced by pilocarpine, rats were decapitated.…”