Lipid Peroxidation in Erythrocyte Membranes of Women with Benign and Malignant Neoplasms of the Endometrium

Abstract

The content of primary and secondary products of membrane peroxidation, total cholesterol concentration, and relative microviscosity of erythrocyte membranes were measured in women with endometrial cancer and uterine leiomyoma. The content of conjugated dienes in erythrocytes was highest in female patients with malignant tumors of the endometrium. The relative microviscosity of erythrocyte membranes in patients with uterine leiomyoma and endometrial cancer was elevated in the zone of lipid--lipid and protein--lipid contacts.

The effect of picosecond laser pulses on redox-dependent processes in mice red blood cells studied in vivo

“…We can assume that due to enhanced peroxidation of erythrocyte membranes, which is evidenced by an increase in the levels of DC, KD in the isopropanol and SB in the isopropanol and heptane phases, the decreased MDA content could be caused by its enhanced binding to the membrane, since our research only focused on free MDA. The decreased MDA level in the second experimental group may be associated with activation of aldehyde dehydrogenase involved in MDA metabolism in erythrocytes [9]. We found an increase in the level of Schiff bases-tertiary LP products -in the heptane and isopropanol phases after PSLI in both modes.…”

“…Our data shows a significant MDA decrease after multiple irradiation with the intensity of 6,37·10 -3 W/cm 2 (410,26 ± 28,99 μmol/l vs. 550,90 ± 84,54 μmol/l in the control group). It is known that MDA has cross-linking bifunctional reagent properties, capable of binding to NH 2 -groups of amino acids, proteins and nitrogenous bases [9]. We can assume that due to enhanced peroxidation of erythrocyte membranes, which is evidenced by an increase in the levels of DC, KD in the isopropanol and SB in the isopropanol and heptane phases, the decreased MDA content could be caused by its enhanced binding to the membrane, since our research only focused on free MDA.…”

Oxidative Stress and Cancer

“…Lower levels of antioxidant enzymes such as superoxide dismutase and catalase as well as lower levels of antioxidants such as vitamin C and E were also observed in plasma of ovarian cancer patients compared to controls [63]. Patients with endometrial cancer also experience elevated oxidative stress, as evidenced by the observation of elevated levels of conjugated dienes in erythrocytes of female patients with malignant tumor of endometrium [65]. Endometrial cancer is the most common form of gynecological malignancy.…”