Lipid peroxidation in cord blood at birth: the effect of labour

Rogers, Michael S.; Mongelli, J.M.; Tsang, K. H.; Wang, Chi Chiu; Law, KT

doi:10.1111/j.1471-0528.1998.tb10204.x

Cited by 70 publications

(57 citation statements)

References 17 publications

(19 reference statements)

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“…This is consistent with the previous findings that high levels of free oxygen radical activity are a function of the labour process and that there is no increase in lipid peroxidation levels in the cord blood of fetuses delivered by LSCS (22). However, maternal oxidative stress levels were higher as indicated by increased MDA and pmteolytic activity.…”

Section: Discussionsupporting

confidence: 92%

Maternal and fetal indicators of oxidative stress in various obstetric complications

Rao

Kamath

Raghothama

et al. 2003

Indian J Clin Biochem

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The present study demonstrates the incidence of increased lipid peroxidation and protein oxidation in both maternal and fetal erythrocytes as markers of oxygen radical activity in different complications of pregnancy. In fetuses born at~er premature rupture of membranes, lipid peroxidation was significantly elevated as indicated by increased malondialdehyde levels (p<0.05) as compared to controls. Proteolytic activity in the erythrocytes of mothers in this group was also significantly high(p<0.01 ). In patients delivered by lower segment cesarian section, lipid peroxidation and proteolytic activity in maternal erythrocytes were significantly high (p<0.05 and p<0.001 respectively). In patients with prolonged second stage of labour, lipid peroxidation and proteolytic activity in maternal erythrocytes was significantly higher than in controls(p<0.001 and p<0o05 respectively). In this group, endogenous protein damage due to oxidative stress was significantly high both in the mother and the fetus (p<0.001 and p<0.05 respectively).

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Section: Discussionsupporting

confidence: 92%

Maternal and fetal indicators of oxidative stress in various obstetric complications

Rao

Kamath

Raghothama

et al. 2003

Indian J Clin Biochem

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“…The decidua vera was dissected by Shah et al 33 from the delivered placenta, whereas our decidual biopsies were obtained by suction from the uterine wall after placental removal. Our samples were obtained at cesarean section before labor had commenced, avoiding unpredictable oxidative stress resulting from various lengths and intensities of labor 34 and thereby a possible effect on the test results. In decidua, renin expression was Ͼ10-fold higher than in placenta, irrespective of preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

Dysregulation of the Circulating and Tissue-Based Renin-Angiotensin System in Preeclampsia

et al. 2007

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Abstract-The renin-angiotensin system (RAS) participates in preeclampsia; however, the relative contributions from the circulating RAS and the tissue-based, uteroplacental RAS are unknown. We hypothesized that the tissue-based uteroplacental RAS is dysregulated in preeclampsia. We performed microarray and gene expression studies and confirmed the findings on the protein level by immunohistochemistry in ureteroplacental units from 10 preeclamptic women and 10 women with uneventful pregnancies. All of the women were delivered by cesarean section. We also analyzed plasma renin activity and circulating agonistic angiotensin II type 1 (AT 1 ) receptor autoantibodies. In preeclampsia, we found that the angiotensin II AT 1 receptor gene was 5-fold upregulated in decidua (maternal origin). We also found AT 1 autoantibodies in preeclamptic women and in their offspring by neonatal cardiomyocyte bioassay compared with women with normal pregnancies and their infants (mother: 17.5Ϯ2.2 versus 0.05Ϯ0.4; fetus: 14.5Ϯ1.8 versus 0.5Ϯ0.5 ⌬bpm). Gene expressions for renin (35.0-fold), angiotensin-converting enzyme (2.9-fold), and angiotensinogen (8.9-fold) were higher in decidua than placenta (fetal origin) in both control and preeclamptic women, whereas the AT 1 receptor was expressed 10-fold higher in placenta than in decidua in both groups. Our findings elucidate the ureteroplacental unit RAS in preeclamptic and normal pregnancies. We found that, in preeclampsia, the AT 1 receptor expression is particularly high in decidua, combined with pregnancy-specific tissue RAS involving decidual angiotensin II production and AT 1 autoantibodies. We also showed that AT 1 autoantibodies cross the ureteroplacental barrier. These components could participate in the pathophysiology of preeclampsia.

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“…Other authors found that spontaneous delivery caused the increase of LPX products levels in plasma of newborns in comparison to those delivered by caesarean section (Rogers et al 1998). According to some authors, TBARS could be used as a more sensitive indicator of foetal tissues injury caused by perinatal hypoxia than ABB parameters (Wang et al 1996;Rogers et al 1999).…”

Section: Resultsmentioning

confidence: 93%

“…Wang et al (1996) reported association between MDA levels and acid-base balance (ABB) parameters in umbilical cord blood, which reflected foetal tissue injury at birth. Moreover, according to Rogers et al (1998), TBARS might be a more sensitive indicator of foetal hypoxia than ABB parameters in umbilical cord blood.…”

Section: Introductionmentioning

confidence: 99%

Lipid peroxidation and biochemical parameters in maternal pre-delivery and post-delivery plasma

et al. 2010

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Lipid peroxidation (LPX) can play an important role in development of functional and pathological changes of maternal tissues in the course of pregnancy and delivery. LPX products were measured as thiobarbituric acid reacting substances (TBARS), using malondialdehyde as the standard solution. Actual TBARS determined in maternal post-delivery plasma (2.71 ± 0.602 nmol/mL) were not statistically different from those determined in pre-delivery plasma (3.45 ± 0.530 nmol/mL). TBARS production was measured in vitro in the both incubated plasma (30 min, 37• C) with and without the added LPX activator (125 µM L-ascorbate plus 5 µM FeSO4). A difference in the TBARS formation was found only in the post-delivery plasma, as a result of approximately twice higher (marginally significant) TBARS formation in the incubated plasma without the added LPX activator comparing with the actual TBARS levels in this plasma. These results suggest that changes in maternal tissues in the process of labour could create suitable conditions for activation of LPX in maternal plasma. On the other hand, all other analysed biochemical parameters (iron, total iron-binding capacity, uric acid, proteins, magnesium, calcium, phosphate, glucose, potassium, sodium, chlorides, alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, creatine kinase, lactate dehydrogenase, α-hydroxybutyrate dehydrogenase, α-amylase, alkaline phosphatase, acid phosphatase in the post-delivery plasma were not different from those analysed in the pre-delivery plasma.

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Lipid peroxidation in cord blood at birth: the effect of labour

Cited by 70 publications

References 17 publications

Maternal and fetal indicators of oxidative stress in various obstetric complications

Maternal and fetal indicators of oxidative stress in various obstetric complications

Dysregulation of the Circulating and Tissue-Based Renin-Angiotensin System in Preeclampsia

Lipid peroxidation and biochemical parameters in maternal pre-delivery and post-delivery plasma

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