2004
DOI: 10.1590/s0100-879x2004000200004 View full text |Buy / Rent full text
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Abstract: Exposure to stress induces a cluster of physiological and behavioral changes in an effort to maintain the homeostasis of the organism. Long-term exposure to stress, however, has detrimental effects on several cell functions such as the impairment of antioxidant defenses leading to oxidative damage. Oxidative stress is a central feature of many diseases. The lungs are particularly susceptible to lesions by free radicals and pulmonary antioxidant defenses are extensively distributed and include both enzymatic an… Show more

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“…Oxidative stress is also related to xenobiotic exposure and different levels of environmental contamination (Halliwell and Gutteridge, 1999). Peroxidation of membrane lipids seems to be an unavoidable process in tissue injury, which can impair antioxidant defenses, those results in oxidative damage by changing the balance between oxidants and antioxidants (Banerjee et al, 1988;Halliwell and Gutteridge, 1999;Torres et al, 2004).…”
Section: Introductionmentioning
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“…Oxidative stress is also related to xenobiotic exposure and different levels of environmental contamination (Halliwell and Gutteridge, 1999). Peroxidation of membrane lipids seems to be an unavoidable process in tissue injury, which can impair antioxidant defenses, those results in oxidative damage by changing the balance between oxidants and antioxidants (Banerjee et al, 1988;Halliwell and Gutteridge, 1999;Torres et al, 2004).…”
Section: Introductionmentioning
“…Rapid urbanization and the changing social fabric in our society lead to heightened levels of stress both mental and physical. Stress exerts detrimental effects on several cellular functions through impairment of antioxidant defenses, leading to oxidative damage, a process central to many diseases (Torres et al 2004). A substantial literature has focused on anatomical, behavioural, and neuroendocrine changes associated to the exposure to chronic stress.…”
Section: Introductionmentioning
“…Oxidative stress pathways play important roles in the regulation of inflammatory mediators that may be involved in atopic responses [20,61,62] . Oxidative stress arises when the balance between pro-oxidants and antioxidants is shifted toward pro-oxidants [61] .…”
Section: Discussionmentioning