Lipid peroxidation and glutathione system in hyperlipemic rabbits: influence of olive oil administration

Cruz, J. P. De La; Quintero, Lourdes; Villalobos, M.A.; Cuesta, Felipe Sánchez de la

doi:10.1016/s1388-1981(00)00027-5

Cited by 61 publications

(40 citation statements)

References 25 publications

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“…The purpose of given cholesterol to male rats is to induce partial infertility has experienced this method in our study, its obvious that hyperlipidemia had a negative effect concerning sperm quality due to ROS reactive oxygen species which lead to hyper oxidative stress since both hypercholesterolemia and hypertriglyceridemia caused an increase of oxygen radicals production and lipid peroxidation level associated with decreased antioxidative effect of glutathione as few studies matched with ours (27) .…”

Section: Discussion:-supporting

confidence: 68%

The Influence of a Combination of Antioxidants on Sub Fertile Male Rat.

Hassooni¹,

KaramM²,

Abod³

et al. 2017

IJAR

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Background: Prescription of a combination of antioxidants might increase the quality of sperm parameters and decrease the serum level of cholesterol and serum level of triglycerine in men who suffer from infertility. Therefore, the present study investigated protective effects of alpha-Lipoic acid (ALA), L-Carnitine (CAR), N-Acytel cysteine (NAC) on sperm parameters and seminiferous tubules epithelium in high-fat diet model. Objectives: is to investigate the serum cholesterol and its effect on male rat's fertility and evaluate the effect of treating them with a certain combination of antioxidants mixed together they were (ALA), L-(CAR) and N-Acytel (NAC). Material and Methods: thirty male rats were administered cholesterol for 2 months to induce hypercholesterolemia to reduce fertility in male rats and consequently treated with a combination of antioxidants to repair the harmful effect of cholesterol. Results: cholesterol administered group were significantly different with those of control group (P<0.05) cholesterol levels were153.51±5.39 and 93.61±4.68 mg/dl while triglyceride was 176.71±12.49 and 83.14±7.08 mg/dl in treated and control group respectively. Also semen parameters showed significant difference between treated and control group (P<0.05) they were 28.46±3.56 and 74.4±6.36 ×106 sperm/ml, 34.23±2.12 and 89.34±2.41%, 32.45±5.23 and3.76±1.22%, 20.34±3.81 and 3.21±1.08% for sperm count, live sperms, sperm agglutination and abnormal sperm percentage in treated and control groups respectively. While after antioxidant administration showed significant difference (P<0.05) with the control group in sperm count, bigger live sperms percentage and lesser abnormal sperms was seen in combination of three antioxidants were (P<0.05) compared to positive control group (non-antioxidant group), sperm agglutination had a significant difference (P<0.05) between all antioxidant treated group compared with positive control group (non-treated group). Conclusion: As it is shown in our study, Oral administration of a combination of antioxidants with diet, decreasing the serum levels of cholesterol and serum level of TG, improving the sperm parameters by decreasing the ROS and protect the liver tissue from the harmful effect of cholesterol. Finally, it seems that the antioxidants in patients with subfertility or infertility is a new and efficient strategy with few side effects.

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Section: Discussion:-supporting

confidence: 68%

The Influence of a Combination of Antioxidants on Sub Fertile Male Rat.

Hassooni¹,

KaramM²,

Abod³

et al. 2017

IJAR

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“…These authors also reported a significant elevation in lipid peroxide levels and GSH-Px, catalase and SOD On the other hand, an HC diet also affects the proox idant and antioxidant balance in the tissues (16)(17)(18)(19)(20)(21). Indeed, severe hypercholesterolemia and vascular ath erosclerotic lesions as well as an increase in oxidative stress in plasma, erythrocytes and several tissues such as liver and aorta have been observed in rabbits follow ing the feeding of an HC diet (16)(17)(18)(19)(20). Contrarily, ath erosclerotic changes were not observed in the aorta of rats following the feeding of an HC diet (12,18,21), although lipid peroxidation increased and the antioxi dant system was affected in some tissues (16,18,21).…”

Section: Discussionmentioning

confidence: 96%

“…On the other hand, a high-cholesterol (HC) diet resulted in a significant increase in serum (16)(17)(18), erythrocyte (19), liver (17,18,20) and aorta (17,18,20) lipid peroxide levels, as well as significant alter ations in the antioxidant system and typical atheroscle rotic changes in the aorta of rabbits. However, in rats, an HC diet does not induce atherosclerotic changes in the aorta (12,21) and erythrocyte hemolysis (22), although this diet produces changes in prooxidant and antioxidant balance in some tissues (16,18,21).…”

mentioning

confidence: 99%

Methionine Supplementation Did Not Augment Oxidative Stress, Atherosclerotic Changes and Hepatotoxicity Induced by High Cholesterol Diet in C57BL/6J Mice

Balkan¹,

Doğru‐Abbasoğlu²,

Çevikbaş

et al. 2004

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…22) Cholesterol feeding also influenced the prooxidant-antioxidant status in these animals. 10,[23][24][25] It has been suggested that there was a close relationship between hypercholesterolemia and lipid peroxidation and that they played a complementary role in atherogenesis. 26,27) In this study, typical atheromatous plaque as well as increases in the cholesterol and lipid peroxide levels in the plasma, liver and aorta were observed in the rabbits fed on the HC diet.…”

Section: Discussionmentioning

confidence: 99%