Effect of a Taurine Treatment on the Regression of Existing Atherosclerotic Lesions in Rabbits Fed on a High-cholesterol Diet

Balkan, Jale; Öztezcan, Serdar; Hatipoglu, Aydan; Çevikbaş, Uğur; Aykaç‐Toker, Gülçin; Uysal, Müjdat

doi:10.1271/bbb.68.1035

Cited by 8 publications

(2 citation statements)

References 29 publications

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“…In this study, we observed that plasma cholesterol remained elevated for over 4 weeks after the initial 2 week or 4 week diet regimen. This clearly shows the impaired cholesterol clearance in the rabbit model and is supported by other studies showing plasma cholesterol do not return to normal in a short period of time Balkan et al. 2004; Fennessy et al.…”

Section: Discussionsupporting

confidence: 83%

High dietary methionine plus cholesterol stimulates early atherosclerosis and late fibrous cap development which is associated with a decrease in GRP78 positive plaque cells

Zulli

Hare

2009

Int J Experimental Path

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The role of homocysteine, or its precursor methionine, in the formation of fibrous caps and its association with endoplasmic reticulum (ER) stress is unclear. Homocysteine can stimulate collagen accumulation and upregulate the ER stress chaperone glucose regulated protein 78 (GRP78). The aim of this study was to determine if high dietary methionine would increase fibrous caps, and that removal of an atherogenic diet would decrease the amount of ER stressed cells. New Zealand white rabbits were fed for 2, 4, or 12 weeks an atherogenic diet [1% methionine + 0.5% cholesterol (2MC, 4MC or 12MC)]; for 4 or 12 weeks a 0.5% cholesterol diet (4Ch, 12Ch); and to study plaque regression, an MC diet for 2 or 4 weeks accompanied by 10 weeks of a normal diet (2MCr, 4MCr). Endothelial function, atherosclerosis and GRP78 positive cells were studied. Endothelial function was abolished in 4MC and atherosclerosis increased 17-fold (P < 0.05) compared with 4Ch. Fibrous caps composed 48% of total plaque area in 12MC vs. 10% in 12Ch (P < 0.01), and 12MC expressed less GRP78 plaque cells vs. 12Ch (P < 0.01). Four MCr had less plaque GRP78 cells than 12MC (P < 0.05) and less endothelial GRP78 cells (P < 0.01). In addition, GRP78 positive cells were the highest in 4MC, but decreased in all other groups (P < 0.01). GRP78 positive cells within the fibrous cap inversely correlated with cap size (r(2) = 0.9). These studies suggest that high dietary methionine could be beneficial for plaque stabilisation, and a normal diet also stabilises plaque and decreases the number of stressed plaque cells.

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Section: Discussionsupporting

confidence: 83%

High dietary methionine plus cholesterol stimulates early atherosclerosis and late fibrous cap development which is associated with a decrease in GRP78 positive plaque cells

Zulli

Hare

2009

Int J Experimental Path

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“…Balcan et al. [] also indicated that taurine has no effect to reduce plasma and liver TC levels in atherosclerotic rabbit during regression period. The above results suggest that different species respond differently to increased cholesterol intake with elevations in blood cholesterol, and taurine may show its antiatherogenic property without having any effect on plasma lipid levels in rabbit.…”

Section: The Effect Of Taurine On Serum and Liver Cholesterol Levels mentioning

confidence: 99%

The effect of taurine on cholesterol metabolism

Chen

Guo²,

Chang³

2012

Molecular Nutrition Food Res

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The elevated plasma cholesterol level, in particular, LDL cholesterol is regarded as an important risk factor for the development of atherosclerosis and coronary artery disease. A number of studies provide the evidence that taurine has the efficient action to reduce plasma and liver cholesterol concentrations, especially to decrease VLDL and LDL cholesterol in hypercholesterolemia animal induced by high cholesterol diet. Cholesterol lowering effect of taurine is actually involved in the regulatory mechanism of cholesterol and bile acid homeostasis that mediated by CYP7A1, which has become a biomarker for cholesterol metabolism and itself is also regulated by several factors and nuclear receptors. This review summarizes the change of cholesterol concentration in metabolism observed in feeding studies of hypercholesterolemia animal dealing with taurine, and then, addresses the possible metabolic and molecular mechanisms of cholesterol lowering effect by taurine in three aspects, cholesterol clearance from blood circulation, bioconversion of cholesterol to bile acid in liver, and excretion of cholesterol and bile acid from intestine.

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Effects of Taurine Supplementation on Cholesterol Levels with Potential Ramification in Atherosclerosis

Lombardini¹,

Militante²

Taurine 6

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Effect of a Taurine Treatment on the Regression of Existing Atherosclerotic Lesions in Rabbits Fed on a High-cholesterol Diet

Cited by 8 publications

References 29 publications

High dietary methionine plus cholesterol stimulates early atherosclerosis and late fibrous cap development which is associated with a decrease in GRP78 positive plaque cells

High dietary methionine plus cholesterol stimulates early atherosclerosis and late fibrous cap development which is associated with a decrease in GRP78 positive plaque cells

The effect of taurine on cholesterol metabolism

Effects of Taurine Supplementation on Cholesterol Levels with Potential Ramification in Atherosclerosis

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