Lipid Nanoparticles Composed of Quaternary Amine–Tertiary Amine Cationic Lipid Combination (QTsome) for Therapeutic Delivery of AntimiR-21 for Lung Cancer

Yung, Bryant C.; Li, Jilong; Zhang, Mengzi; Cheng, Xinwei; Li, Hong; Yung, Elaine M.; Chen, Kang; Cosby, Lauren E.; Liu, Yang; Teng, Lirong; Lee, Robert J.

doi:10.1021/acs.molpharmaceut.5b00878

Cited by 66 publications

(57 citation statements)

References 43 publications

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“…The simulations in Fig 12(a) mimic this experiment; the effect of PTX is accounted for by reducing 1.4 λ Ci to 1.3 λ Ci ( i = 1, 2), and the effect of anti-miR-21 is accounted for by reducing λ m 1 to λ m 1 /2. We note however that in our model the cancer is at an earlier stage and its volume is much smaller compared to the volume of 0.8 cm 3 in [42]. …”

Section: Resultsmentioning

confidence: 80%

“…Researches have observed that paclitaxel-treated cells have defects in mitotic spindle assembly, chromosome segregation and cell division [41]. Experiments in vivo by Yung et al [42] show that anti-miR-21 reduces tumor volume in NSCLC, and the combination of paclitaxel and anti-miR-21 demonstrated greater ability to reduce cancer cell proliferation than either agent administered alone. The simulations in Fig 12(a) mimic this experiment; the effect of PTX is accounted for by reducing 1.4 λ Ci to 1.3 λ Ci ( i = 1, 2), and the effect of anti-miR-21 is accounted for by reducing λ m 1 to λ m 1 /2.…”

Section: Resultsmentioning

confidence: 99%

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Exosomal miRs in Lung Cancer: A Mathematical Model

Lai

Friedman²

2016

PLoS ONE

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Lung cancer, primarily non-small-cell lung cancer (NSCLC), is the leading cause of cancer deaths in the United States and worldwide. While early detection significantly improves five-year survival, there are no reliable diagnostic tools for early detection. Several exosomal microRNAs (miRs) are overexpressed in NSCLC, and have been suggested as potential biomarkers for early detection. The present paper develops a mathematical model for early stage of NSCLC with emphasis on the role of the three highest overexpressed miRs, namely miR-21, miR-205 and miR-155. Simulations of the model provide quantitative relationships between the tumor volume and the total mass of each of the above miRs in the tumor. Because of the positive correlation between these miRs in the tumor tissue and in the blood, the results of the paper may be viewed as a first step toward establishing a combination of miRs 21, 205, 155 and possibly other miRs as serum biomarkers for early detection of NSCLC.

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Section: Resultsmentioning

confidence: 80%

Section: Resultsmentioning

confidence: 99%

Exosomal miRs in Lung Cancer: A Mathematical Model

Lai

Friedman²

2016

PLoS ONE

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“…While numerous nanomedicines have been developed for the delivery of anticancer drugs, there are limited studies on antipsychotic delivery. [Kim et al, ; Yung et al, ] Given the lack of the knowledge of the underlying mechanisms of psychosis, improving the delivery of current antipsychotics using nanoparticle‐based administration is a rational approach. Of all the nanomaterials, solid‐lipid and polymeric nanoparticles are the most likely to achieve success in the short term due to their long history of medical use and proven biocompatibility.…”

Section: Resultsmentioning

confidence: 99%

Delivery of Antipsychotics with Nanoparticles

Sun

Chen

Liu

et al. 2016

Drug Development Research

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Preclinical Research Psychosis remains one of the most challenging health problems for society, affecting hundreds of millions of people worldwide. Although current antipsychotics can alleviate the symptoms of psychosis, they are still far away from being perfect, often causing significant and even fatal side effects such as involuntary movement disorders and metabolic syndrome. With the lack of precise knowledge of the underlying mechanisms of psychosis, a rational approach to improve the efficiency of current antipsychotics is by nanoparticle-based administration. Nanoparticles with the size of 1-500 nm can be used in drug formulations to pass through many biological barriers including the blood-brain barrier, which makes them excellent candidates for the delivery of antipsychotics. Besides that, nanoparticles loaded with antipsychotics can solve the common aqueous solubility issues for most brain targeting drugs, and enable a slow-release profile for the encapsulated drugs. This research overview provides a brief summary and discussion of the progress and development in the delivery of antipsychotics with nanoparticle formulations over the past five years (2011-2016). Drug Dev Res 77 : 393-399, 2016. © 2016 Wiley Periodicals, Inc.

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“…Many studies were thus conducted to define the effectiveness of specific miRNA therapeutics for the treatment of NSCLC in animal models in vivo (Table ). AntagomiRs were employed for the inhibition of tumor promotive miR‐21‐5p, miR‐183‐5p, and miR‐206‐3p and shown to inhibit subcutaneous A549 tumors . Whereas, tumor suppressive miRNAs let‐7b‐5p or miR‐34a‐5p reduced KRAS‐activated tumor burden in vivo .…”

Section: Therapeutic Potential Of Micrornas Demonstrated In Nsclc Animentioning

confidence: 99%

MicroRNAs in non‐small cell lung cancer: Gene regulation, impact on cancer cellular processes, and therapeutic potential

Petrek

2019

Pharmacology Res & Perspec

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Lung cancer remains the most lethal cancer among men and women in the United States and worldwide. The majority of lung cancer cases are classified as non‐small cell lung cancer (NSCLC). Developing new therapeutics on the basis of better understanding of NSCLC biology is critical to improve the treatment of NSCLC. MicroRNAs (miRNAs or miRs) are a superfamily of genome‐derived, small noncoding RNAs that govern posttranscriptional gene expression in cells. Functional miRNAs are commonly dysregulated in NSCLC, caused by genomic deletion, methylation, or altered processing, which may lead to the changes of many cancer‐related pathways and processes, such as growth and death signaling, metabolism, angiogenesis, cell cycle, and epithelial to mesenchymal transition, as well as sensitivity to current therapies. With the understanding of miRNA biology in NSCLC, there are growing interests in developing new therapeutic strategies, namely restoration of tumor suppressive miRNAs and inhibition of tumor promotive miRNAs, to combat against NSCLC. In this article, we provide an overview on the molecular features of NSCLC and current treatment options with a focus on pharmacotherapy and personalized medicine. By illustrating the roles of miRNAs in the control of NSCLC tumorigenesis and progression, we highlight the latest efforts in assessing miRNA‐based therapies in animal models and discuss some critical challenges in developing RNA therapeutics.

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Lipid Nanoparticles Composed of Quaternary Amine–Tertiary Amine Cationic Lipid Combination (QTsome) for Therapeutic Delivery of AntimiR-21 for Lung Cancer

Cited by 66 publications

References 43 publications

Exosomal miRs in Lung Cancer: A Mathematical Model

Exosomal miRs in Lung Cancer: A Mathematical Model

Delivery of Antipsychotics with Nanoparticles

MicroRNAs in non‐small cell lung cancer: Gene regulation, impact on cancer cellular processes, and therapeutic potential

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