Delivery of Antipsychotics with Nanoparticles

Abstract

Preclinical Research Psychosis remains one of the most challenging health problems for society, affecting hundreds of millions of people worldwide. Although current antipsychotics can alleviate the symptoms of psychosis, they are still far away from being perfect, often causing significant and even fatal side effects such as involuntary movement disorders and metabolic syndrome. With the lack of precise knowledge of the underlying mechanisms of psychosis, a rational approach to improve the efficiency of current antipsychotics is by nanoparticle-based administration. Nanoparticles with the size of 1-500 nm can be used in drug formulations to pass through many biological barriers including the blood-brain barrier, which makes them excellent candidates for the delivery of antipsychotics. Besides that, nanoparticles loaded with antipsychotics can solve the common aqueous solubility issues for most brain targeting drugs, and enable a slow-release profile for the encapsulated drugs. This research overview provides a brief summary and discussion of the progress and development in the delivery of antipsychotics with nanoparticle formulations over the past five years (2011-2016). Drug Dev Res 77 : 393-399, 2016. © 2016 Wiley Periodicals, Inc.

The Effectiveness of Combined Drug Delivery Systems

“…To build a self-assembly structure, camptothecin is conjugated with short oligo ethylene glycol. This can enable the patient to overcome drug resistance [9][10][11][12][13] . Similar to these conjugates, the nanoparticles that originate from the polymer self-assembly are highly effective.…”

“…Curcumin is yet another polyphenol that engages in anticancer activity and also down regulates the pathways from functioning and progressing the cancer cells further to other parts. It is observed that the co-delivery has a higher potential to control MDR and this only requires the proper selection of the nanotherapeutic delivery system to choose inhibitor/ sensitizer/ modulator [9][10][11]37 .…”

Peptide-based Drug Delivery for Curing Cancer

“…The first section of this review details about the assembly of peptides while the next part discusses more on the influence of peptide-based ligand on the health of the patient. Peptides quickly turn into proteins and can penetrate to the top layer of the patient's skin thereby having a long-term impact of the medicine [6][7][8][9][10][11] . The final part of this report discusses how peptides can serve as better drug delivery mechanism leaving a significant development in the health aspect of the person.…”

Peptide Conjugated Lipid Nanoparticles for Anti-Cancer Drug Delivery

“…The process of self-assembly results in the formation of micro and nanoscale structures that find application in cancer therapy because of their unique and tunable nanostructures. While combination chemotherapeutics and nanotechnology are indeed useful for targeted drug delivery and improved treatment efficacy, a challenge continues to exist in the form of active targeting ligand that can be used [1][2][3][4][5][6][7] . This work is a review of peptides like the peptide conjugated lipid nanoparticles that are used in cancer treatment delivery.…”