Lipid nanocapsules co-encapsulating paclitaxel and salinomycin for eradicating breast cancer and cancer stem cells

Polypropylene sulphide coating on magnetic nanoparticles as a novel platform for excellent biocompatible, stimuli-responsive smart magnetic nanocarriers for cancer therapeutics

“…Doxorubicin-loaded PPS NPs (PPS-MnFe-Dox) were used to measure their uptake into MCF7 cells by flow cytometry according to the reported protocol. 43 Briefly, 10 5 cells per well were seeded in a 12-well plate and allowed to attach overnight. Then, cells were incubated with PPS-DOX NPs at an equivalent DOX concentration of 1 µg mL −1 for 0.5, 1 and 3 h. After incubation, the cells were washed with 1× PBS and collected by enzymatic dissociation using trypsin.…”

Recent advances in the targeted delivery of paclitaxel nanomedicine for cancer therapy

“…54,55 The physicochemical properties of paclitaxel can also be modified using an epoxidized copolymer, which forms nanoparticles with a lower micelle size and critical micelle concentration and better loading capacity and encapsulation. 56,57 Paclitaxel is a hydrophobic drug, and hence shows more efficient release from epoxidized nanomicelles, which are also biodegradable. 58,59 The pharmaceutical excipients studied as potential conjugates for paclitaxel are cyclodextrins.…”

Natural Products-Based Nanoformulations: A New Approach Targeting CSCs to Cancer Therapy

“…The combined application of these two natural compounds significantly induced CSC apoptosis and tumor mammosphere growth, showing superior cytotoxicity and anti-CSC properties. 104 Hyaluronan was coated on the surface of polymeric nanoparticles coloaded with PTX and salinomycin, which actively targeted CD44 receptors overexpressed on CSCs and eradicated tumors by killing the cancer cells and CSCs. 105 This suggests that combination therapy with conventional chemotherapeutic agents and CSC inhibitors may be a promising approach to overcome cancer recurrence caused by drug-resistant cell populations.…”