Polypropylene sulphide coating on magnetic nanoparticles as a novel platform for excellent biocompatible, stimuli-responsive smart magnetic nanocarriers for cancer therapeutics

Abstract

Magnetic nanoparticle (MNP) delivery systems are promising for targeted drug delivery, imaging, and chemo-hyperthermia of cancer, however, their uses remain limited primarily due to their toxicity associated to reactive oxygen...

Reversal of Multidrug Resistance by the Synergistic Effect of Reversan and Hyperthermia to Potentiate the Chemotherapeutic Response of Doxorubicin in Glioblastoma and Glioblastoma Stem Cells

“…The obtained intrinsic loss power (ILP) is around 2.5 nHm 2 /kg, and the specific power absorption (SAR) value is 2240 ± 10 W/g. Further details concerning the magnetic and physicochemical characterization of prepared nanoparticles can be found in the previous paper of our lab …”

“…PPS-MnFe nanoparticles were prepared by the previously reported method by our group by coating magnetic nanopartilces (MNPs) with PPS polymer using the anionic polymerization emulsion method. , Shortly, MNPs prepared by the seed-mediated thermal decomposition method were dissolved in toluene (7 mg/20 μL) and further mixed with propylene sulfide (PS). The prepared solution was injected in the pluronic F127 (60 mg) and borax (16 mg) preprepared solution (3 mL) water under an inert environment.…”

“…A 2 mg/mL concentration of magnetic nanoparticle in water/media was used throughout the hyperthermia studies. The concentration of MnFe nanoparitcle was determined by calorimetric method using standard plot of metal ions (Figure SI 2) as described in our previous publication …”

“…Drug-loaded nanoparticles were tied in the dialysis membrane and kept in 10 mL of release media for 72 h for a normal physiological release study. Concentrations of 5 and 50 mM H 2 O 2 in 1× PBS (pH 7.4) and in acidic pH 4.5 (containing 0.01% w/v butylated hydroxytoluene and 0.1% w/v N -acetylcysteine (NAC) were used for low-pH and oxidative conditions …”

pH-Responsive Polypropylene Sulfide Magnetic Nanocarrier-Mediated Chemo-Hyperthermia Kills Breast Cancer Stem Cells by Long-Term Reversal of Multidrug Resistance and Chemotherapy Resensitization

“…Magnetic nanoparticles (MNPs) composed of MnFe were synthesized using a seed-mediated high-temperature decomposition method . The process involved combining iron acetylacetonate and manganese acetylacetonate in a 2:1 molar ratio with oleic acid (2.3 mL), allyl amine (2.8 mL), hexadecanediol (2.5 g), and phenyl ether (25 mL) in a three-necked round-bottom flask.…”