1971
DOI: 10.1007/bf02531171
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Lipid metabolism of acetate‐1‐14C by leukocytes from dogs fed an arteriosclerosis‐inducing diet

Abstract: Dogs were maintained on a control ration or on a semisynthetic diet, containing 5% cholesterol and 16% hydrogenated coconut oil, known to induce hyperlipemia and arteriosclerosis. Circulating leukocytes isolated from dogs fed the coconut oil containing diet were shown to incorporate 50% more radioactivity into lipids than control leukocytes when incubated with acetate-1A 4C. This increase, expressed as dpm/mg of leukocyte DNA, was not specific for any particular lipid since the distribution of radioactivity be… Show more

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Cited by 7 publications
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“…These cells are incapable of glyconeogenesis (Stjernholm, Noble, Dimitrov, Morton & Falor, 1969) or fatty acid synthesis de nouo (Majerus & Lastra, 1967). Glucose is incorporated into lipids predominantly as glycerol (Miras et al, 1967) whereas acetate is incorporated via mitochondria1 elongation of endogenous fatty acids (Miras, Mantzos & Levis, 1965 ;Ehrhart, Balachandran, Butkus, Lewis & Robertson, 1971). Lymphocytes incorporate acetate in the same manner (Blomstrand, 1966), though there is some evidence that phytohaemagglutinin-stimulated cells are capable of synthesis de nouo (Blomstrand & Liljeqvist, 1972).…”
Section: Discussionmentioning
confidence: 95%
“…These cells are incapable of glyconeogenesis (Stjernholm, Noble, Dimitrov, Morton & Falor, 1969) or fatty acid synthesis de nouo (Majerus & Lastra, 1967). Glucose is incorporated into lipids predominantly as glycerol (Miras et al, 1967) whereas acetate is incorporated via mitochondria1 elongation of endogenous fatty acids (Miras, Mantzos & Levis, 1965 ;Ehrhart, Balachandran, Butkus, Lewis & Robertson, 1971). Lymphocytes incorporate acetate in the same manner (Blomstrand, 1966), though there is some evidence that phytohaemagglutinin-stimulated cells are capable of synthesis de nouo (Blomstrand & Liljeqvist, 1972).…”
Section: Discussionmentioning
confidence: 95%