1975
DOI: 10.1042/cs0490343
|View full text |Cite
|
Sign up to set email alerts
|

Effect of Phenylalanine and Its Metabolites on the Metabolism of Leucocytes and Lymphocytes

Abstract: 1. The pathogenesis of the mental retardation in phenylketonuria remains obscure. Leucocytes have proved of value in the study of other inborn errors of metabolism. The lymphocyte is a suitable model cell for the study of mammalian metabolism, because of its ability to divide in vitro in response to various stimuli. 2. We have examined the effects of phenylalanine, phenylpyruvate, phenyl-lactate and phenylacetate on the human leucocyte and the resting and phytohaemagglutinin-stimulated rabbit lymphocyte. 3. Ph… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
1
0

Year Published

2000
2000
2000
2000

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
(1 citation statement)
references
References 33 publications
0
1
0
Order By: Relevance
“…Previous studies have shown that phenolic compounds moderately inhibit cholesterol synthesis (Shah et al, 1968(Shah et al, , 1969Ramasarma, 1973, 1974;Bradley and Mahler, 1975;Bhat and Ramasarma 1979;Castillo et al, 1991;Samid et al, 1994;Prasanna et al, 1996). The focus of this manuscript is to determine if there is a relationship between the moderate inhibition of cholesterol biosynthesis and white matter pathology in PKU forebrain.…”
mentioning
confidence: 93%
“…Previous studies have shown that phenolic compounds moderately inhibit cholesterol synthesis (Shah et al, 1968(Shah et al, , 1969Ramasarma, 1973, 1974;Bradley and Mahler, 1975;Bhat and Ramasarma 1979;Castillo et al, 1991;Samid et al, 1994;Prasanna et al, 1996). The focus of this manuscript is to determine if there is a relationship between the moderate inhibition of cholesterol biosynthesis and white matter pathology in PKU forebrain.…”
mentioning
confidence: 93%