Lipid metabolism in the newborn heart.

Altered maternal thyroid function: Effect of L-carnitine supplementation on fetal and neonatal myocardial free fatty acid oxidation,in vitro

“…The observed low FFA oxidation by fetal hearts is in agreement with the previous findings (13,16). However, in offsprings born of hyporthyroid mothers FFA utilization by heart remained low even at day of birth and 7 days neonatal age in comparison to control rats.…”

Fatty acid oxidation and ketogenesis during development

“…The capacity of heart (Wittels and Bressler, 1965 ;Warshaw and Terry, 1970 ;Warshaw, 1972 ;Mersmann and Phinney, 1973 ;Aprille, 1976 ;Wolfe, Maxwell and Nelson, 1978 ;Werner et al, 1982Werner et al, , 1983a, skeletal muscle (Wolfe, Maxwell and Nelson, 1978 ;Glatz and Veerkamp, 1982 ;Carroll et al, 1983) and kidney (Wolfe, Maxwell and Nelson, 1978 ;Freund, Sedraoui and Geloso, 1984) to oxidize NEFA increases shortly after birth in rats, rabbits, pigs and calves. In contrast, it has been reported that substantial fatty acid oxidation occurs only 2 weeks after birth in dog heart (Breuer et al, 1968).…”

“…A rise in this activity occurs immediately after birth in the heart (Wittels and Bressler, 1965 ;Warshaw, 1972 ;Lockwood and Bailey, 1970 ;Barrie and Harris, 1977), skeletal muscle (Carroll et al, 1983), lung (Warshaw, Terry and Ranis, 1980) and kidney (Delaval et al, 1984) of rats and remains elevated throughout the suckling period. However, CAT activity does not change with age in the heart, leg muscles and kidney of pigs, although palmitate oxidation increases 2 to 3-fold (Wolfe, Maxwell and Nelson, 1978).…”

Human Chorionic Somatomamotraophin and Its Clinical Significance

“…Although the hormonal changes of pregnancy are very complex it seems likely that these changes are, at least in part, the result of HCS secretion. Their overall effect may be considered to make the maternal metabolism more dependent on fat, thereby ensuring the supplies of glucose to the fetus which may be its preferred substrate (Wittels & Bressler, 1965;Shelley & Neligan, 1966).…”