Lipid metabolism in inflammation-related diseases

Zhang, Cuiping; Wang, Ke; Yang, Lujie; Liu, Ronghua; Chu, Yiwei; Qin, Xue; Yang, Pengyuan; Yu, Hongxiu

doi:10.1039/c8an01046c

Cited by 123 publications

(114 citation statements)

References 132 publications

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“…In our study, we show that eicosanoids are increased in the microvesicles of pregnant women who experienced preterm birth. A previous study suggested that eicosanoids played an essential role in proinflammation [38]. We also found that the level of PA is increased in microvesicles and exosomes of pregnant women who experienced preterm birth.…”

Section: Discussionsupporting

confidence: 72%

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Lipidomic profiling of plasma extracellular vesicles as an effective means to evaluate the risk of preterm birth

Zhao

Wang

et al. 2020

Preprint

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Preterm birth is the main cause of infant death worldwide and results in a high societal economic burden associated with newborn care. Recent studies have shown that extracellular vesicles play an important role in fetal development during pregnancy. Here, we fully investigated differences in lipids in plasma, microvesicles and exosomes between 27 preterm and 66 full-term pregnant women in the early second trimester (12-24 weeks) using an untargeted lipidomics approach. Independent of other characteristics of samples, we detected 97, 58 and 10 differential features (retention time (RT) and m/z) with identification by multivariate and univariate statistical analyses in plasma, microvesicles and exosomes, respectively. These altered lipids were involved in the formation of the bacterial cell wall and chronic low-level inflammation and oxidative stress. Furthermore, lipids in microvesicles could distinguish patients who experienced preterm labor from controls better than lipids in plasma and exosomes. The candidate lipid biomarkers in microvesicles were also validated by the pseudotargeted lipidomics method. The validation set included 41 preterm and 42 healthy pregnant women. PS (34:0) in microvesicles was able to distinguish preterm birth from healthy pregnancy with higher accuracy. Our study shows that differences in lipids in plasma, microvesicles and exosomes are useful for understanding the underlying mechanisms, early clinical diagnosis and intervention of preterm birth.

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Section: Discussionsupporting

confidence: 72%

“…A recent study showed that circulating Cer was associated with insulin resistance and chronic low-level inflammation in individuals with obesity [38]. In our study, we show that eicosanoids are increased in the microvesicles of pregnant women who experienced preterm birth.…”

Section: Discussionsupporting

confidence: 67%

Lipidomic profiling of plasma extracellular vesicles as an effective means to evaluate the risk of preterm birth

Zhao

Wang

et al. 2020

Preprint

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“…Presently, lipids were considered as an effective signal molecule to regulate multiple cellular responses. A variety of lipid-derived mediators were involved in the regulation of inflammation as well as infection response [77,78]. For example, lipid-derived mediators Prostaglandin E2 (PGE 2 ) and Prostacyclin (PGI 2 ) functioned as vasodilator agents in the initial stage of inflammation for the recruitment of various immune cells, such as neutrophils and macrophages from the blood to the infected or damaged tissues [79].…”

Section: Discussionmentioning

confidence: 99%

Exploration of Anti-inflammatory Mechanism of Forsythiaside A and Forsythiaside B in CuSO4-Induced Inflammation in Zebrafish by Metabolomic and Proteomic Analyses

Gong

et al. 2020

Preprint

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Background: Inflammation is a general pathological phenomenon during severe disturbance of homeostasis. Forsythiaside A (FA) and Forsythiaside B (FB) are phenylethanoid components isolated from dried fruits of Forsythia suspensa (Thunb.) Vahl., which show a significant effect against inflammation. However, the anti-inflammatory properties and therapeutic mechanisms of FA and FB have not yet been systematically clarified. Methods: In this study, the anti-inflammatory effects of FA and FB were investigated in CuSO4-induced inflammation in zebrafish. Intracellular ROS and NO generation in zebrafish were investigated using fluorescent probes. Metabolomics and proteomics analyses using liquid chromatography mass spectrometry were carried out to identify the expressions of metabolites and proteins associated with the treatment of FA and FB in CuSO4-induced inflammation in zebrafish larvae. Quantitative polymerase chain reaction (PCR) was performed to detect the progressive changes in genes. Results: FA and FB inhibited neutrophils migration to the damaged neuromasts and remarkably reduced CuSO4-induced ROS and NO generation in zebrafish. Metabolomic analysis indicated that Nicotinate and nicotinamide metabolism, Energy metabolism, Pyrimidine metabolism and Purine metabolism were mainly involved. Proteomic analysis identified 146 differentially expressed proteins between control and model group. The changed expressions of Collagen (collagen type II alpha 1b precursor (col2a1b), collagen alpha-2(IX) chain precursor (col9a2), collagen type IX alpha I precursor (col9a1b)), nucleoside diphosphate kinase 3 isoform X1 (Nme3), WD repeat-containing protein 3 (Wdr3), 28S ribosomal protein S7 mitochondrial precursor (Mrps7) in model group were all reversed after being treated by FA or FB. FA and FB could reverse the abnormal expressions of potential metabolite and protein biomarkers to alleviate CuSO4 damage to the neuromasts in the lateral line of zebrafish. Conclusions: Our results indicated that FA and FB possessed remarkable anti-inflammatory activities against CuSO4-induced neuromasts damage in zebrafish larvae, and suggested a multi-component and multi-regulatory therapeutic mechanism of FA and FB.

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“…Lipids are essential structural components of cell membranes and play a crucial role in different metabolic pathways and cellular functions [ 226 ]. Lipids alteration is associated with cardiovascular risk [ 70 ].…”

Section: Lipid Molecules and Lipoproteinsmentioning

confidence: 99%

Depression and Cardiovascular Disease: The Viewpoint of Platelets

Amadio

Zara

Sandrini

et al. 2020

IJMS

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Depression is a major cause of morbidity and low quality of life among patients with cardiovascular disease (CVD), and it is now considered as an independent risk factor for major adverse cardiovascular events. Increasing evidence indicates not only that depression worsens the prognosis of cardiac events, but also that a cross-vulnerability between the two conditions occurs. Among the several mechanisms proposed to explain this interplay, platelet activation is the more attractive, seeing platelets as potential mirror of the brain function. In this review, we dissected the mechanisms linking depression and CVD highlighting the critical role of platelet behavior during depression as trigger of cardiovascular complication. In particular, we will discuss the relationship between depression and molecules involved in the CVD (e.g., catecholamines, adipokines, lipids, reactive oxygen species, and chemokines), emphasizing their impact on platelet activation and related mechanisms.

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Lipid metabolism in inflammation-related diseases

Cited by 123 publications

References 132 publications

Lipidomic profiling of plasma extracellular vesicles as an effective means to evaluate the risk of preterm birth

Lipidomic profiling of plasma extracellular vesicles as an effective means to evaluate the risk of preterm birth

Exploration of Anti-inflammatory Mechanism of Forsythiaside A and Forsythiaside B in CuSO4-Induced Inflammation in Zebrafish by Metabolomic and Proteomic Analyses

Depression and Cardiovascular Disease: The Viewpoint of Platelets

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