Lipid metabolism in cancer: A systematic review

Abstract

Preclinical studies and clinical trials have emphasized the decisive role of lipid metabolism in tumor proliferation and metastasis. This systematic review aimed to explore the existing literature to evaluate the role and significance of the genes and pathways most commonly involved in the regulation of lipid metabolism in cancer. The literature search was performed as per Preferred Reporting Items for Systematic Reviews and Meta-analyses. Approximately 2396 research articles were initially selected, of which 215 were identified as potentially relevant for abstract review. Upon further scrutiny, 62 of the 215 studies were reviews, seminars, or presentations, and 44 were original study articles and were thus included in the systematic review. The predominant gene involved in lipid metabolism in cancer was stearoyl-coenzyme A desaturase 1 (SCD1), followed by fatty acid synthase (FASN). The pathway most commonly involved in lipid metabolism in cancer was the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathway, followed by the mitogen activated protein kinase (MAPK) pathway. SCD1 and FASN play significant roles in the initiation and progression of cancer and represent attractive targets for potentially effective anti-cancer treatment strategies. The regulation of cancer metabolism by the Akt kinases will be an interesting topic of future study.

Prognosis and Characterization of Microenvironment in Cervical Cancer Influenced by Fatty Acid Metabolism-Related Genes

“…However, rare research studies focus on the correlation between the prognosis of CC and FAM, which needs to be elucidated. Furthermore, the FAM can be regulated by oncogenic signalling pathway directly, namely, growth-factor receptor tyrosine kinases (RTKs)/RAS [11], phosphoinositide 3-kinase/protein kinase B (PI3K/AKT), and the mitogenactivated protein kinase (MAPK) signalling pathway [12]. However, the mechanisms driving particular FAM phenotypes in CC are still unclear.…”

Implantation of engineered adipocytes that outcompete tumors for resources suppresses cancer progression

“…For glycolysis, these include drugs that target hexokinase 2 (HK2), which is involved in the initial steps in glycolysis, using ATP from the mitochondria to phosphorylate glucose, or drugs that target glucose transporters (GLUT1 and GLUT4) (2,(6)(7)(8). Several drugs are also used to target lipid metabolism in cancer (9)(10)(11)(12). These include drugs that target lipid uptake (targeting proteins such as LXR, CD36 and FABP4/5), lipogenic enzymes (such as ACC, ACLY, FASN, and SCD1) and proteins involved in intracellular lipid homeostasis (such as CPT1A, PPARG and others) (13,14).…”

Evaluation of pro‐atherogenic lipid profile and high atherohenic indexes in patients with Behçet's disease: A case–control study

“…Serum lipid levels are important in many disorders' current status and progression, especially in cardiovascular and cerebrovascular diseases. In addition, recent experimental studies indicate that lipid metabolism plays a decisive role in tumor proliferation and metastases in cancer 5 . In these diseases, most of which develop on the basis of atherosclerogenic plaque, chronic inflammation is thought to be effective in plaque formation and rupture.…”

“…In addition, recent experimental studies indicate that lipid metabolism plays a decisive role in tumor proliferation and metastases in cancer. 5 In these diseases, most of which develop on the basis of atherosclerogenic plaque, chronic inflammation is thought to be effective in plaque formation and rupture. It is pointed out that in addition to classical markers such as CRP and ESR, IL-6, CXCL12 and hs-CRP can be used to define this inflammation in the laboratory.…”