2021
DOI: 10.1016/j.devcel.2021.02.024
|View full text |Cite
|
Sign up to set email alerts
|

Lipid metabolism in adaptation to extreme nutritional challenges

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
9
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
6
2
1

Relationship

1
8

Authors

Journals

citations
Cited by 26 publications
(9 citation statements)
references
References 146 publications
0
9
0
Order By: Relevance
“…The effects of lipids on infection development play a pivotal role. The function of lipids was gradually decrypted, which was used as an alternative source in pathologic conditions ( Olsen et al, 2021 ), and was involved in the virus infection, was involved in transport of cell membrane, and activated intricate signaling pathways related to the immune system ( Yu et al, 2021 ). Lipid metabolism dysfunction in the host has extensive effects on immune cells.…”
Section: Discussionmentioning
confidence: 99%
“…The effects of lipids on infection development play a pivotal role. The function of lipids was gradually decrypted, which was used as an alternative source in pathologic conditions ( Olsen et al, 2021 ), and was involved in the virus infection, was involved in transport of cell membrane, and activated intricate signaling pathways related to the immune system ( Yu et al, 2021 ). Lipid metabolism dysfunction in the host has extensive effects on immune cells.…”
Section: Discussionmentioning
confidence: 99%
“…Our work also reveals specific genes and lipids that could be critical for long-term survival in suspended development. Lipids that accumulate in a state of 'suspended animation' (e.g., very long-chain fatty acids) could serve as key substrates for long-lasting survival (62,63).…”
Section: Discussionmentioning
confidence: 99%
“…For example, transcription factors whose motifs are enriched in the diapause state (e.g., FOXOs, PPARs) are genetically required for suspended animation states, such as C. elegans dauer (67-69), and are expressed in mammalian hibernation (70). Furthermore, lipids and lipid metabolism genes are expressed differentially in mammalian diapause (71) as well as hibernation and torpor (63,72,73), and are under positive selection in exceptionally long-lived mammals (74).…”
Section: Discussionmentioning
confidence: 99%
“…Astyanax mexicanus has emerged as a powerful system to understand the genetic and physiological basis of metabolic adaptation to nutrient deprived habitats (2)(3)(4)(5)(6)(7)(8)(9)(10). The species comes in two morphotypes -the surface fish that live in lush, nutrient-rich rivers and the blind cavefish that dwell in dark and nutrient-poor caves in the Sierra de El Abra of northeast Mexico.…”
Section: Introductionmentioning
confidence: 99%