Lipid metabolism and apolipoprotein E phenotypes in patients with xanthelasma

Ribera, Miquel; Pintó, Xavier; Argimón, Josep M.; Fiol, C.; Pujol, Ramón; Ferrándiz, Carlos

doi:10.1016/s0002-9343(99)80224-1

Cited by 47 publications

(42 citation statements)

References 26 publications

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“…11–15 Tursen et al have recommended evaluation of apolipoproteins in all XP patients to unmask the atherosclerosis risk if any 12. On the contrary, no difference in Apo-A1 was observed between patients and controls by Ribera et al 15 and Gomez et al 25 Increased Apo-B has been reported in all the three previously mentioned studies (table 3). Many other authors did not evaluate for apolipoproteins 4 5 17…”

Section: Discussionmentioning

confidence: 97%

“…In such patients with normal cholesterol, various other factors namely reduced HDL-C levels, altered lipoprotein content or structure, paraprotein disturbances, genetic factors and mast cell activation have been implicated in the pathogenesis of XP 9 10. Gomez et al 25 and Ribera et al 15 have also documented the role of reduced HDL-C in the causation of XP. However, similar to the present study (table 3), no difference in HDL-C levels between patients and controls was seen by Jain et al 4 and Sharma et al 11.…”

Section: Discussionmentioning

confidence: 99%

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Xanthelasma palpebrarum: a marker of premature atherosclerosis (risk of atherosclerosis in xanthelasma)

Pandhi

Gupta²,

Singal³

et al. 2012

Postgraduate Medical Journal

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Xanthelasma palpebrarum: a marker of premature atherosclerosis (risk of atherosclerosis in xanthelasma)

Pandhi

Gupta²,

Singal³

et al. 2012

Postgraduate Medical Journal

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“…It has been reported that metabolic syndrome is associated in some cases with psoriasis with an accelerated development of atherosclerosis [28]. Xanthelasma can be associated with hypercholesterolemia with low-density lipoprotein (LDL) increase [29]. …”

Section: Introductionmentioning

confidence: 99%

Prevalence of Acne Vulgaris in Patients with Down Syndrome

et al. 2010

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Background/Objective: Acne vulgaris exhibits a worldwide prevalence of up to 95% among adolescents. On the other hand, Down syndrome is an autosomal chromosomal disorder with associated dermatoses and a tendency to obesity. There are no data on its association with acne. Our aim was to detect the prevalence of acne, its forms and associated factors in Down syndrome. Method: A cross-sectional study including 89 subjects aged 10–28 years from Associação de Pais e Amigos dos Excepcionais-São Paulo to verify acne, metabolic and hormonal disorders by interview, clinical and laboratory examinations. Results: We evaluated 49 (55%) males and 40 (45%) females. A weak agreement between self-estimation for acne and examination result was detected. The overall prevalence of acne was 70.8%: 83.7% in males and 55% in females. The prevalence of acne in the age groups 10–17 and 18–28 was 62 and 78.7%, respectively. Facial comedonal acne was mostly detected. The prevalence of obesity was 40%, that of metabolic disorders 7% and that of hyperandrogenism (in females) 15%. Except for gender, no other factor evaluated correlated with acne. Conclusion: A low prevalence of acne in Down syndrome, a predominance in males aged 18–28 and a facial comedonal form were detected. An association with obesity, metabolic disorders or hyperandrogenemia was not assessed.

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“…7 Chhetri et al reported a different peak age group of 40-50 years and found 41.84 % of the XP cases in this age group. 12 Previous studies have reported correlation between diabetes and hypertension to XP. Sankar SP, Samuel P reported that 28% patients of XP were diabetic and 20% were hypertensive while Gangopadadhya et Incidence of DM associated with XP was reported to be 6% by Ribera et al and 34.2% by Vacca et al 12,13 In our study of patients with XP, average fasting blood sugar was 108gm% and average post prandial blood sugar was 152gm% (Table 2).…”

Section: Fig 1: 81% Females and 19% Malesmentioning

confidence: 97%

Neurotization in brachial plexus injury â€“ A 3 year experience in tertiary government institution

2020

IJN

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Introduction: Xanthelasma palpebrum (XP) is a disorder of lipid metabolism that usually presents as bilateral and symmetrical, soft velvety papules and plaques around the eyelids. Though various factors contribute to its etiology, a strong association with lipid metabolism is proposed. Usually seen in middle age people, its main concern is cosmetic appearance. Objective: 1. To evaluate the lipid profile, glycemic levels, Body Mass Index (BMI) in patients with Xanthelasma palpebrum. 2. To find the association between parameters like age, sex and comorbid illness with Xanthelasma palpebrum. Materials and Methods: This prospective study included 42 clinically diagnosed patients with Xanthelasma Palpebrarum and 95 subjects in control group with non-inflammatory skin disorders. Levels of serum triglyceride, cholesterol, HDL, LDL, VLDL, blood sugar -fasting and post prandial were determined in all cases along with body mass index and blood pressure. These parameters were compared in both groups and association with XP was analysed. Results and Discussion: In our study, XP was more common in females compared to males. In our study of patients with XP, average fasting blood sugar was 108 gm% and average post prandial blood sugar was 152gm%. Average serum triglyceride levels in patients with XP was 171.4 mg/dl, compared to 108.4 mg/dl in control group with significant p value i.e. 0.001, suggesting strong correlation between XP and serum triglyceride levels. Conclusion: Patients with XP usually visit doctor with cosmetic concern. In most of the cases of XP, serum cholesterol, triglyceride and VLDL levels are deranged. Patients with XP should be evaluated for above parameters and systemic management done along with treatment of XP.

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Lipid metabolism and apolipoprotein E phenotypes in patients with xanthelasma

Cited by 47 publications

References 26 publications

Xanthelasma palpebrarum: a marker of premature atherosclerosis (risk of atherosclerosis in xanthelasma)

Xanthelasma palpebrarum: a marker of premature atherosclerosis (risk of atherosclerosis in xanthelasma)

Prevalence of Acne Vulgaris in Patients with Down Syndrome

Neurotization in brachial plexus injury â€“ A 3 year experience in tertiary government institution

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