Lipid metabolic effect of Korean red ginseng extract in mice fed on a high‐fat diet

Song, Yong-Bum; An, Yu; Kim, Seung Jun; Park, Hyewon; Jung, Jinwook; Kyung, Jong-Soo; Hwang, Seung Yong; Kim, Young-Sook

doi:10.1002/jsfa.4589

Cited by 82 publications

(62 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With ASE supplementation, the upregulation of Cyp7a1 increased the production of bile acids and reduced the level of cholesterol in hepatocytes. Similar findings were observed in rats treated with Korean red ginseng extract and platycodin D [45], [46]. Apoh encodes a single chain glycoprotein that has been implicated in the development of atherosclerosis.…”

Section: Discussionsupporting

confidence: 79%

Digital Gene-Expression Profiling Analysis of the Cholesterol-Lowering Effects of Alfalfa Saponin Extract on Laying Hens

Zhou

Guo

et al. 2014

PLoS ONE

View full text Add to dashboard Cite

BackgroundTo prevent cardiovascular disease, people are advised to limit their intake of dietary cholesterol to less than 300 mg/day. Egg consumption has been seriously reduced because of the high levels of cholesterol. The purpose of the present study was to evaluate the cholesterol-lowering effects of alfalfa saponin extract (ASE) in yolk and the molecular mechanisms underlying these effects using digital gene-expression profiling analysis. Liver and ovary tissues were isolated from laying hens fed with ASE for RNA sequencing.ResultsThe cholesterol content of the yolks of eggs from hens fed 120 mg/kg ASE declined considerably on day 60. Other groups (60, 240, 480 mg/kg ASE group) also showed decreases, but they were not significant. Digital gene expression generated over nine million reads per sample, producing expression data for least 12,384 genes. Among these genes, 110 genes showed greater than normal expression in the liver and 107 genes showed greater than normal expression in the ovary. Cholesterol 7 alpha-hydroxylase (Cyp7a1) and apolipoprotein H (Apoh), which act in the synthesis of bile acid and cholesterol efflux, showed more expression in the livers of hens given dietary ASE supplementation. In the ovary, levels of very low density lipoprotein receptor (Vldlr), apolipoprotein B (Apob), apovitellenin 1 (ApovldlII) and vitellogenin (VtgI, VtgII and VtgIII) in ovary decreased with dietary ASE supplementation.ConclusionTranscriptome analysis revealed that the molecular mechanisms underlying the cholesterol-lowering effects of ASE were partially mediated by enhancement of cholesterol efflux in the liver and this reduced of cholesterol deposition in the ovary.

show abstract

Section: Discussionsupporting

confidence: 79%

Digital Gene-Expression Profiling Analysis of the Cholesterol-Lowering Effects of Alfalfa Saponin Extract on Laying Hens

Zhou

Guo

et al. 2014

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…RG intake down-regulated genes associated with lipid metabolism, which are up-regulated by a high-fat diet [10,11]. Based on these previous studies, we expected that RG intake would further increase fat oxidation when combined with endurance training, which is known to increase the rate of fatty acid mobilization in intramuscular fat [21].…”

Section: Discussionmentioning

confidence: 99%

“…A 10-day in vivo administration of ginseng extract modulates peroxisome proliferator-activated receptor-α function, which regulates the expression of a number of genes critical for lipid and lipoprotein metabolism, and significantly increases serum concentrations of total cholesterol, triglycerides, and high-density lipoprotein cholesterol [9]. In a study by Song et al [10], mice were fed a high-fat diet containing RG for 13 weeks and the authors found that genes associated with lipid metabolism were down-regulated; these genes are usually up-regulated by a high-fat diet. In studies demonstrating the effect of ginseng on exercise performance, acute ginseng intake after a three-hour swimming exercise improved recovery from fatigue, suggesting an effect of ginseng on endurance exercise performance.…”

Section: Introductionmentioning

confidence: 99%

Red Ginseng Treatment for Two Weeks Promotes Fat Metabolism during Exercise in Mice

et al. 2014

View full text Add to dashboard Cite

PURPOSE: Red ginseng (RG) has been reported to improve the blood and organ lipid profile when combined with exercise. However, the effect of RG on energy metabolism during exercise is poorly understood. Therefore, this study was designed to investigate whether RG treatment alters fat utilization during exercise; METHODS: We used seven-week-old ICR mice (n = 42). RG (1 g/kg) was administered orally daily during two weeks of endurance training. All mice were randomized into two groups: training only group (CON group) and training with RG group (RG group). Endurance training consisted of 20~25 m/min on a slope of 8° for one hour five times a week. After a two-week experimental period, we measured substrate utilization during exercise at the same intensity and duration of training using a respiratory calorimetry chamber. Mice were dissected for glycogen measurement of muscles and liver before, immediately after, and one hour after the exercise; RESULT: Fat oxidation during the initial 20 min of the one-hour exercise significantly increased in the RG group compared to the CON group. In addition, the liver glycogen stores significantly decreased immediately after the one-hour exercise compared to at rest in the RG group, but did not differ between immediately after the one-hour exercise and at rest in the RG group. The glycogen concentration in white and red gastrocnemius muscle did not differ between the groups immediately after the one-hour exercise; CONCLUSIONS: These results suggest that RG treatment for two weeks promotes fat oxidation and a glycogen-sparing effect during exercise. This might lead to a delay in peripheral fatigue during endurance exercise performance.

show abstract

“…15) Red ginseng extract reduced serum triglyceride and total cholesterol levels by downregulation of genes related to lipid and cholesterol metabolism in high-fat diet fed mice. 16) Supplementation of KRG reduced body weight by inhibiting angiogenesis in diet-induced obese mice. 8) A recent study reported that red ginseng is effective to prevent from damaging liver function by oxidative stress than white ginseng.…”

Section: )mentioning

confidence: 99%

Effects of Korean Red Ginseng extract on hepatic lipid accumulation in HepG2 cells

Lee

Kim

et al. 2015

Bioscience, Biotechnology, and Biochemistry

View full text Add to dashboard Cite

Korean Ginseng, the root Panax ginseng CA Meyer, has been widely used as a traditional herbal medicine in East Asian countries. In this study, we investigated the effects of Korean Red Ginseng water extract (KRGE) on hepatic lipid accumulation in HepG2 cells. First, we investigated the cytotoxic effects of KRGE on HepG2 cells. Cytotoxicity was unaffected in the concentrations of 1–50 μg/ml of KRGE.Intracellular lipid accumulation was assessed by the quantification of intracellular triglyceride and cholesterol contents. KRGE decreased hepatic triglyceride and cholesterol levels. Moreover, KRGE suppressed expression of fatty acid synthase (FAS) and 3‐hydroxy‐3‐methyl glutaryl coenzyme A (HMG‐CoA) reductase, a rate‐limiting enzyme in hepatic cholesterol synthesis. These results suggest that KRGE may reduce hepatic lipid accumulation by inhibition of FAS and HMG‐CoA reductase expression in HepG2 cells. Consequently, KRGE may be beneficial as a functional food ingredient to improve various hepatic diseases by reducing hepatic lipid accumulation.

show abstract

Lipid metabolic effect of Korean red ginseng extract in mice fed on a high‐fat diet

Abstract: KRGE regulated the expression of genes associated with abnormal physiology via HFD. Leptin, insulin, and adiponectin, which carry out critical functions in energy and lipid metabolism, were shown to be modulated by KRGE. These results show that KRGE is effective in preventing obesity.

Cited by 82 publications

References 23 publications

Digital Gene-Expression Profiling Analysis of the Cholesterol-Lowering Effects of Alfalfa Saponin Extract on Laying Hens

Digital Gene-Expression Profiling Analysis of the Cholesterol-Lowering Effects of Alfalfa Saponin Extract on Laying Hens

Red Ginseng Treatment for Two Weeks Promotes Fat Metabolism during Exercise in Mice

Effects of Korean Red Ginseng extract on hepatic lipid accumulation in HepG2 cells

Contact Info

Product

Resources

About