Lipid mediator profile in vernix caseosa reflects skin barrier development

Checa, Antonio; Holm, Tina; Sjödin, Marcus; Reinke, Stacey N.; Alm, Johan; Scheynius, Annika; Wheelock, Craig E.

doi:10.1038/srep15740

Cited by 15 publications

(9 citation statements)

References 27 publications

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“…In addition, a higher prevalence was observed in females (p=0.034; OR=1.7). Vernix is an indication of fetal maturity and epidermal synthesis because the levels of its production, along with that of ceramides, rise between 39 and 40 weeks 33 34 , 35 Although described, 17 the association of vernix and gestational age over 40 weeks was not observed in our study.…”

Section: Discussioncontrasting

confidence: 62%

Dermatoses in the Early Neonatal Period: Their Association With Neonatal, Obstetric and Demographic Variables

Krüger

Sinkos

Uhry

et al. 2019

Rev. paul. pediatr.

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Objective: To evaluate the prevalence of neonatal dermatoses in the early neonatal period and to associate them with neonatal, demographic and obstetric variables.Methods: A cross-sectional study with neonates and their respective mothers, who were hospitalized in a public maternity hospital in Curitiba, PR, Brazil. Data collection was performed using information present in the medical records and a physical examination of the newborn during the period between April 2015 and May 2016.Results: 350 neonates were evaluated. 54.8% were male, and 94.8% (332/350) presented a dermatosis. Among them, 84.6% had, concomitantly, two or more dermatoses. A total of 23 types of dermatoses were diagnosed. The most prevalent were: sebaceous hyperplasia (66%); fluff (42.6%); and salmon patches (41.4%). The mean age of the mothers was 24.9±4.9 years old, and they were predominately white (57.7%). Vernix caseosa was associated with the female gender (p=0.034). Nonwhite mothers were associated with genital hyperpigmentation (p=0.03) and Mongolian spots (p=0.001). Physiological flaking was associated with cesarean deliveries (p=0.03) and a gestational age of over 40 weeks (p=0.054). Salmon patches was associated with primiparity (p=0.0001).Conclusions: There was a high prevalence of neonatal dermatosis in the studied population. Each newborn had, on average, three different dermatoses. Dermatosis in neonates was associated with primiparity, nonwhites, a gestational age of over 40 weeks, and the sex of the newborn.

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Section: Discussioncontrasting

confidence: 62%

Dermatoses in the Early Neonatal Period: Their Association With Neonatal, Obstetric and Demographic Variables

Krüger

Sinkos

Uhry

et al. 2019

Rev. paul. pediatr.

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“…Moreover, 12, 13-DiHome was increased in vernix caseosa as a protective layer in human skin. 36 The diverse evidence may support the existence of metabolite-mediated gut-skin axis communications ( Figure ).…”

Section: Metabolite Pathwaymentioning

confidence: 99%

Microbiome in the Gut-Skin Axis in Atopic Dermatitis

Lee

Park

2018

Allergy Asthma Immunol Res

213

206

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The microbiome is vital for immune system development and homeostasis. Changes in microbial composition and function, termed dysbiosis, in the skin and the gut have recently been linked to alterations in immune responses and to the development of skin diseases, such as atopic dermatitis (AD). In this review, we summarize the recent findings on the gut and skin microbiome, highlighting the roles of major commensals in modulating skin and systemic immunity in AD. Although our understanding of the gut-skin axis is only beginning, emerging evidence indicates that the gut and skin microbiome could be manipulated to treat AD.

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“…Detailed information of the separation and general MS conditions is provided in Additional file 5 . Retention times and SRM transitions for each compound can be found elsewhere [ 22 , 25 , 26 ].…”

Section: Methodsmentioning

confidence: 99%

Soluble epoxide hydrolase derived lipid mediators are elevated in bronchoalveolar lavage fluid from patients with sarcoidosis: a cross-sectional study

et al. 2018

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BackgroundSarcoidosis is a systemic inflammatory multi-organ disease almost always affecting the lungs. The etiology remains unknown, but the hallmark of sarcoidosis is formation of non-caseating epithelioid cells granulomas in involved organs. In Scandinavia, > 30% of sarcoidosis patients have Löfgren’s syndrome (LS), an acute disease onset mostly indicating a favorable prognosis. The impact of dysregulation of lipid mediators, which has been investigated in other inflammatory disorders, is still unknown.MethodsUsing three different liquid chromatography coupled to tandem mass spectrometry targeted platforms (LC-MS/MS), we quantified a broad suite of lipid mediators including eicosanoids, sphingolipids and endocannabinoids in bronchoalveolar lavage (BAL) fluid from pulmonary sarcoidosis patients (n = 41) and healthy controls (n = 16).ResultsA total of 47 lipid mediators were consistently detected in BAL fluid of patients and controls. After false discovery rate adjustment, two products of the soluble epoxide hydrolase (sEH) enzyme, 11,12-dihydroxyeicosa-5,8,14-trienoic acid (11,12-DiHETrE, p = 4.4E-5, q = 1.2E-3, median fold change = 6.0) and its regioisomer 14,15-dihydroxyeicosa-5,8,11-trienoic acid (14,15-DiHETrE, p = 3.6E-3, q = 3.2E-2, median fold change = 1.8) increased in patients with sarcoidosis. Additional shifts were observed in sphingolipid metabolism, with a significant increase in palmitic acid-derived sphingomyelin (SM16:0, p = 1.3E-3, q = 1.7E-2, median fold change = 1.3). No associations were found between these 3 lipid mediators and LS, whereas levels of SM 16:0 and 11,12-DiHETrE associated with radiological stage (p < 0.05), and levels of 14,15-DiHETrE were associated with the BAL fluid CD4/CD8 ratio.ConclusionsThese observed shifts in lipid mediators provide new insights into the pathobiology of sarcoidosis and in particular highlight the sEH pathway to be dysregulated in disease.Electronic supplementary materialThe online version of this article (10.1186/s12931-018-0939-0) contains supplementary material, which is available to authorized users.

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Lipid mediator profile in vernix caseosa reflects skin barrier development

Cited by 15 publications

References 27 publications

Dermatoses in the Early Neonatal Period: Their Association With Neonatal, Obstetric and Demographic Variables

Dermatoses in the Early Neonatal Period: Their Association With Neonatal, Obstetric and Demographic Variables

Microbiome in the Gut-Skin Axis in Atopic Dermatitis

Soluble epoxide hydrolase derived lipid mediators are elevated in bronchoalveolar lavage fluid from patients with sarcoidosis: a cross-sectional study

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