Lipid fluidity at different regions in LDL and HDL of β-thalassemia/Hb E patients

Morales, Noppawan Phumala; Charlermchoung, Chalermkhwan; Luechapudiporn, Rataya; Yamanont, Paveena; Fucharoen, Suthat; Chantharaksri, Udom

doi:10.1016/j.bbrc.2006.09.106

Cited by 10 publications

(4 citation statements)

References 36 publications

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“…The ESR results demonstrated a magnitude of increased lipid fluidity in thalassemic lipoproteins. Lipid fluidity at the LDL and HDL cores showed a good correlation with the oxidative stress markers and the αtocopherol level, suggesting that the hydrophobic region of the thalassemic lipoprotein would be a target site for oxidative damage [179]. Gas chromatography/mass spectrometric (GS/MS) technique has been validated in quantifying ortho-and meta-tyrosine as biomarkers of protein oxidative damage in plasma samples of β-thalassemia patients [180].…”

Section: Evaluation Of Oxidative Stress and Antioxidant Status In Thamentioning

confidence: 99%

Antioxidants as Complementary Medication in Thalassemia

Srichairatanakool¹,

Fucharoen²

2014

Pharmacology and Nutritional Intervention in the Treatment of Disease

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Inhibitors of iron absorption (tea, Ca) Foods (phytate and oxalate) Antioxidative compounds (vitamin C, E, NAC) Antioxidative phytochemicals (flavonoids, curcuminoids) Oxidative stress Hemosiderosis Cardiomyopathy Liver inflammation and cirrhosis Thalassemias with iron overload (From Nature Genetics Review, 2004) Endocrinopathy Ineffective erythropoiesis Hormone supplement Hb F modifiers (hydroxyurea, hydroxycarbamide, decitabin and phenylbutyrate) Hb stimulating agents (erythropoietin, folic acid) Bone marrow transplantation Gene therapy HSC therapy (www.nctrallawblog.com) Blood transfusion (420 ml/unit  200 mg Fe) (http://saschina.org) Duodenal iron absorption (3-9 mg Fe/day in thalassemia intermedia) Bone deformity Hypercoagulability Vitamin D Osteoclast supplement Hydroxyurea Aspirin Coumadin Antioxidants as Complementary Medication in Thalassemia

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Section: Evaluation Of Oxidative Stress and Antioxidant Status In Thamentioning

confidence: 99%

Antioxidants as Complementary Medication in Thalassemia

Srichairatanakool¹,

Fucharoen²

2014

Pharmacology and Nutritional Intervention in the Treatment of Disease

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“…The correlations between oxidized lipid products at RT 9.6 min and % decreases of CA and CL suggest that formation of oxidized lipid products depends on the amounts of CA and CL and that these products result from lipid peroxidation of CA and CL. Oxidation of lipoproteins is a site‐specific process, with modification of lipid fluidity near the hydrophobic region of the phospholipid layer and markedly at the core of lipoproteins (Morales et al, ; Phumala et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Lipid composition and α‐tocopherol in he‐oxLDL were determined by a modified HPLC method described by Luechapudiporn, Morales, Fucharoen, and Chantharaksri () and Morales et al (). Briefly, 100 μL of LDL sample was combined with 200 μL of 10 mM PBS.…”

Section: Methodsmentioning

confidence: 99%

Effects of turmeric extract on hemin-induced low-density lipoprotein oxidation

et al. 2018

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Hemin is an oxidative mediator elevated in disease states including sickle cell anemia and thalassemia. The rhizome of Curcuma longa L. contains yellow pigments called curcuminoids which have antioxidant and anti-inflammatory activities. The aim of the study was to compare the protective effects of curcuminoids, curcumin, demethoxycurcumin, bisdemethoxycurcumin, and tetrahydrocurcumin on hemin-induced LDL oxidation (he-oxLDL). He-oxLDL showed the depletion of a-tocopherol, an increase in thiobarbituric acid reactive substances (TBARs), and alteration of the lipid composition in low-density lipoprotein. The levels of cholesteryl arachidonate, cholesteryl linoleate and the cholesteryl linoleate/cholesteryl oleate ratio were decreased. All test compounds showed antioxidant activity that protected against hemin-induced lipid peroxidation, based on the inhibition of TBARs formation, reduced depletion of a-tocopherol, decreased damage to lipids, and a reduced decrease in the cholesteryl linoleate/cholesteryl oleate ratio. A significant protective effect against he-oxLDL was found to be tetrahydrocurcumin curcumin curcuminoids > demethoxycurcumin bisdemethoxycurcumin a-tocopherol (p < .05). Practical applicationsCurcuma longa L. has traditionally been used in Ayurvedic medicine for treatment of conditions such as arthritis, ulcer, jaundice, wounds, and skin diseases. It has also been used as a food additive. The results from this study demonstrated that curcuminoids derived from the rhizome of Curcuma longa L. are the potential substances for protecting hemin-induced LDL oxidation which may be developed as a functional food for the prevention of diseases related to low-density lipoprotein oxidation. K E Y W O R D Scholesteryl ester, curcuminoids, hemin, oxidized LDL, tetrahydrocurcumin

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“…Although conflicting reports are available, 3,9 increased oxidative stress and the oxidative modification of lipoproteins have been reported in BTM, and have been suggested to relate to atherogenesis risk. 2,10,11 In contrast, little is known about the oxidative status 12 and the risk of atherogenesis 13 in BTM patients. In addition, to the best of our knowledge, there is no report regarding paraoxonase activity, which contributes to the antiatherogenic effect of HDL and has preventive effect on the oxidative modification of LDL in BTM patients.…”

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confidence: 89%