Lipid-dendrimer nanohybrid system or dendrosomes: evidences of enhanced encapsulation, solubilization, cellular uptake and cytotoxicity of bortezomib

Kumar, Vinay; Khan, Iliyas; Gupta, Umesh

doi:10.1007/s13204-020-01515-7

Cited by 9 publications

(2 citation statements)

References 44 publications

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“…The lower cell viability of BTZ-encapsulated NPs compared to free BTZ was also observed in MDA-MB-231 cells, as reported previously . The probable reasons include the high cellular uptake, responsive release of the NPs, and the different cellular uptake mechanism of free BTZ . Given the variances in pH and ATP levels between tumor cells and normal cells, the multi-stimuli-responsive NPs may result in higher cytotoxicity specifically in tumor cells.…”

Section: Resultssupporting

confidence: 79%

“…49 The probable reasons include the high cellular uptake, responsive release of the NPs, and the different cellular uptake mechanism of free BTZ. 50 Given the variances in pH and ATP levels between tumor cells and normal cells, the multi-stimuli-responsive NPs may result in higher cytotoxicity specifically in tumor cells. To test this hypothesis, we evaluated the cytotoxicity of BTZ@NPs in both 4T1 cells and HUVEC.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Multi-Stimuli-Responsive Nanoparticles Formed of POSS–PEG for the Delivery of Boronic Acid-Containing Therapeutics

Wang,

Du,

et al. 2023

Biomacromolecules

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Polymeric vehicles often exhibit batch-to-batch variations due to polydispersity, limiting their reproducibility for biomedical applications. In contrast, polyhedral oligomeric silsesquioxane (POSS) has emerged as an attractive candidate for drug delivery due to its precise chemical structure and rigid molecular shape. A promising strategy to enhance drug efficacy while reducing systemic toxicity is the development of multi-stimuli-responsive delivery systems capable of targeted drug release at a disease site. Herein, we developed a drug delivery platform based on POSS–polymer conjugates. By functionalizing the POSS with amino groups and establishing B–N coordination with boronic acids, the nanoparticles (NPs) exhibit responsive behavior to stimuli, including adenosine-5′-triphosphate (ATP), acidic pH, and nucleophilic reagents. We successfully encapsulated two boronic acid-containing molecules: tetraphenylethylene (TPE), serving as a fluorescent probe, and bortezomib (BTZ), an anticancer drug. The TPE@NPs were employed to visualize the cellular uptake of NPs by tumor cells, while the BTZ@NPs exhibited increased cytotoxicity in tumor cells compared with normal cells. This POSS–PEG conjugate offers a nanoparticle platform for encapsulating versatile boronic acid-containing molecules, thereby enhancing drug efficacy while minimizing systemic toxicity. Given the wide-ranging applications of boronic acid-containing molecules in biomedicine, our platform holds significant promise for the development of intelligent drug delivery systems for diagnostics and therapeutics.

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Section: Resultssupporting

confidence: 79%

Section: ■ Results and Discussionmentioning

confidence: 99%