Lipid composition and prostaglandin synthesis in mouse lung microsomes: Alterations following the ingestion of menhaden oil

Lokesh, Belur R.; Kinsella, John E.

doi:10.1007/bf02534766

Cited by 17 publications

(6 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When lauric acid is fed to rats, it fails to enter phospholipids of cardiac tissue (3), lung microsomes ( 12), and lymph (1). Dietary erucic acid is predominantly found in TAG of cardiac (14) and adrenal tissue (6).…”

Section: Oilseed Fatty Acid Metabolismmentioning

confidence: 99%

A Comparison of the Metabolic Fate of Fatty Acids of Different Chain Lengths in Developing Oilseeds

Battey¹,

Ohlrogge²

1989

Plant Physiol.

View full text Add to dashboard Cite

To determine if medium and long chain fatty acids can be appropriately metabolized by species that normally produce 16 and 18 carbon fatty acids, homogenates of developing Cuphea wrightii, Carthamus tinctorius, and Crambe abyssinica seeds were incubated with radiolabeled lauric, palmitic, oleic, and erucic acids. In all three species, acyl-CoA synthetase showed broad substrate specificity in synthesis of acyl-coenzyme A (CoA) from any of the fatty acids presented. In Carthamus, two-to fivefold less of the foreign FAs, lauric, and erucic acid was incorporated into acyl-CoAs than palmitic and oleic acid. Lauric and erucic acid also supported less glycerolipid synthesis in Carthamus than palmitic and oleic acid, but the rate of acyl-CoA synthesis did not control rate of glycerolipid synthesis. In all species examined, medium and long chain fatty acids were incorporated predominantly into triacylglycerols and were almost excluded from phospholipid synthesis, whereas palmitic and oleic acid were found predominantly in polar lipids. However, the rate of esterification of unusual fatty acids to triacylglycerol is slow in species that do not normally synthesize these acyl substrates.

show abstract

Section: Oilseed Fatty Acid Metabolismmentioning

confidence: 99%

A Comparison of the Metabolic Fate of Fatty Acids of Different Chain Lengths in Developing Oilseeds

Battey¹,

Ohlrogge²

1989

Plant Physiol.

View full text Add to dashboard Cite

show abstract

“…However, there are few reports which address the rates and extent of incorporation and distribution of n-3 PUFA in various tissues in man and experimental animals following fish oil ingestion (Thorngren & Gustafson, 1981 ;Iritani & Narita, 1984;Herold & Kinsella, 1986;Swanson et al 1987~). Differences in the magnitude of modification of tissue fatty acid composition and alteration in eicosanoid synthesis induced by fish oil ingestion have also been observed between species, tissues and lipid classes (Croft et al 1984;Lokesh et al 1985;Sanders, 1985a, 6 ;Knapp et al 1986). …”

mentioning

confidence: 99%

Dietary menhaden oil: effects on the rate and magnitude of modification of phospholipid fatty acid composition of mouse heart and brain

1988

View full text Add to dashboard Cite

1. Male CD-1 white mice, 18-20 g body-weight, were given semi-purified diets containing 100 g menhaden oil (MO) or hydrogenated coconut oil (HCO)/kg for 23 d. Mice were killed on days 0, 3, 5, 7, 14, 23. After 23 d of MO supplementation the remaining mice were switched to the HCO diet for an additional 10 d.2. The progressive change(s) in the polyunsaturated fatty acid (PUFA) composition of cardiac and brain phospholipid classes were followed during the MO supplementation and depletion periods. 3.The content of fatty acids 20:5n-3, 22:5n-3 and 22:6n3 increased immediately following ingestion of the MO diet and continued to increase at a steady rate in both heart and brain phospholipid classes.4. In general, the period required to reach steady-state was 1 week for n-3 PUFA and 18:2n-6, and 2 weeks for 20 : 4n-6. 5. Cessation of MO consumption for 10 d resulted in marked decreases in the content of n-3 PUFA and increases in n-6 PUFA in cardiac phospholipids in particular. Brain phospholipids were less responsive.6. The results suggest that dietary fish oil must be consumed for at least 1 week before maximum changes in PUFA composition are observed, and fish oil ingestion must be continuous to maintain elevated n-3 PUFA levels in heart and brain phospholipids.

show abstract

“…The delay in foetal growth caused by fish-oil diets has been ascribed to an insufficient n -6 essential fatty acid intake (Clarke et al, 1988). The deficit in these fatty acids affects important physiological functions related to membrane phospholipids and inhibits of prostanoid synthesis (Lokesh and Kinsella, 1985).…”

Section: Resultsmentioning

confidence: 99%

Comparative Effects of the Fat Extracted from Raw and Fried Sardines Upon Rat Growth and Zinc Bioavailability

Pérez-Granados¹,

Vaquero²,

Navarro

2003

Food sci. technol. int.

View full text Add to dashboard Cite

Three diets containing 8% olive oil, fresh sardine (Clupea pilchardus) oil and oil from sardines fried in olive oil were prepared. After in vitro digestion, soluble (dialysed and non-dialysed) and insoluble zinc fractions were determined. Fresh sardine oil and oil from sardines fried in olive oil provided more dialysed zinc and less insoluble zinc than 8% olive oil. Three groups of growing rats consumed the diets for 28 days. Food intake and body weight values of rats fed 8% olive oil were significantly higher than those fed fresh sardine oil and slightly lower than those fed oil from sardines fried in olive oil. Animals fed fresh sardine oil exhibited the lowest apparent zinc retention during days 5-12, but absorption efficiency increased during days 21-28 and all groups had similar final zinc absorption and retention values. Animals fed oil from sardines fried in olive oil displayed higher (days 5-12) or similar (days 21-28) apparent zinc absorption and retention values than rats fed 8% olive oil and fresh sardine oil. Hepatic zinc concentrations were higher in rats fed oil from sardines fried in olive oil than fed fresh sardine oil, while all groups showed similar spleenic concentrations. Zinc accumulation in skin was significantly higher in animals fed fresh sardine oil than in those fed oil from sardines fried in olive oil, and their total erythrocyte zinc concentrations were also higher than in rats fed oil from sardines fried in olive oil or on 8% olive oil. In conclusion, a diet high in raw sardine fatty acids can cause excessive zinc accumulation in skin and erythrocytes. However, these negative effects of sardine oil disappear after frying in olive oil.

show abstract

Lipid composition and prostaglandin synthesis in mouse lung microsomes: Alterations following the ingestion of menhaden oil

Cited by 17 publications

References 38 publications

A Comparison of the Metabolic Fate of Fatty Acids of Different Chain Lengths in Developing Oilseeds

A Comparison of the Metabolic Fate of Fatty Acids of Different Chain Lengths in Developing Oilseeds

Dietary menhaden oil: effects on the rate and magnitude of modification of phospholipid fatty acid composition of mouse heart and brain

Comparative Effects of the Fat Extracted from Raw and Fried Sardines Upon Rat Growth and Zinc Bioavailability

Contact Info

Product

Resources

About