Lipid-coated ZnO nanoparticles synthesis, characterization and cytotoxicity studies in cancer cell

Abstract

ZnO nanoparticles are widely used in biological, chemical, and medical fields, but their toxicity impedes their wide application. In this study, pristine ZnO NPs (~ 7 nm; ~ 18 nm; ~ 49 nm) and lipid-coated ZnO NPs (~ 13 nm; ~ 22 nm; ~ 52 nm) with different morphologies were prepared by chemical method and characterized by TEM, XRD, HRTEM, FTIR, and DLS. Our results showed that the lipid-coated ZnO NPs (~ 13 nm; ~ 22 nm; ~ 52 nm) groups improved the colloidal stability, prevented the aggregation and dissolution of nanocrystal particles in the solution, inhibited the dissolution of ZnO NPs into Zn 2+ cations, and reduced cytotoxicity more efficiently than the pristine ZnO NPs (~ 7 nm; ~ 18 nm; ~ 49 nm). Compared to the lipid-coated ZnO NPs, pristine ZnO NPs (~ 7 nm; ~ 18 nm; ~ 49 nm) could dose-dependently destroy the cells at low concentrations. At the same concentration, ZnO NPs (~ 7 nm) exhibited the highest cytotoxicity. These results could provide a basis for the toxicological study of the nanoparticles and direct future investigations for preventing strong aggregation, reducing the toxic effects of lipid-bilayer and promoting the uptake of nanoparticles by HeLa cells efficiently.

Journey of ZnO quantum dots from undoped to rare-earth and transition metal-doped and their applications

“…Impurity element detection is one of these applications, which is not applicable using nanoparticles. Apart from impurity detection, energy storage, 117 gas and chemical sensing, 118 optoelectronics, 20,119 anti-bacterial, 120 cancer treatment, 121,122 cellular imaging, 123,124 electronics, 125 and photocatalytic activity 126 are the other major application elds of QDs. However, these QDs will denitely augment the performance of these devices, which have based on nanoparticles to date.…”

Blueprinting in Coherence to Diagnostic Momentum: On Account of Cancer Detection in Bahawalpur Community

“…There are many ways to diagnosed the cancer at early stage via characterisation of images generated from computed tomography (CT), judicated eye image, screening using DNA HPV testing [12], [13], metal ions signaling protein and nanotechnology [14] [15].…”

Effects of Metal Oxide Nanoparticles in Zebrafish

“…In addition to their increasing employment in theragnostic and therapeutics, a lot of questions have been raised on their impact on the aquatic systems [123] and the potentially negative and toxic effects in different organisms. To address the toxicity of these nanoparticles, a lot of studies have been performed on bacteria, plants [124,125], cells [8,126], and vertebrates [4,127].…”