Lipid-based nanoparticles for dermal drug delivery

Badıllı, Ulya; Gümüştaş, Mehmet; Uslu, Bengi

doi:10.1016/b978-0-12-813663-8.00009-9

Cited by 18 publications

(14 citation statements)

References 146 publications

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“…Lipid-based nanoparticles for drug delivery are a promising approach among many nanotechnology-based drug carrier systems. 13 Briefly, lipid-based nanocarriers are classified as liposomes, self-emulsifying drug delivery systems, solid lipid nanoparticles (SLNs), and nanostructured lipid carriers. 14 Liposomes have a short shelf-life, poor colloidal stability, and high cost.…”

Section: Introductionmentioning

confidence: 99%

Acoustic Cavitation-Assisted Formulation of Solid Lipid Nanoparticles using Different Stabilizers

2019

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Because of excellent bioavailability and high biocompatibility, solid lipid nanoparticles (SLNs) have gained attention in recent years, especially in drug delivery systems. SLNs are composed of a drug that is loaded in a lipid matrix and stabilized by surfactants. In this work, we have investigated the feasibility of the acoustic cavitation-assisted hot melt mixing method for the formulation of SLNs using different stabilizers. A lipid Compritol 888 ATO (CPT) and a poorly water-soluble drug ketoprofen (KP) were used as a model lipid and drug, respectively. Gelucire 50/13 (GEL), poloxamer 407 (POL), and Pluronic F-127 (PLU) were used as the stabilizers. The effect of the stabilizers on the physico-chemical properties of SLNs was thoroughly studied in this work. The particle size and stability in water at different temperatures were measured using a dynamic light scattering method. The spherical shape (below 250 nm) and core–shell morphology were confirmed by field-emission scanning electron microscopy and transmission electron microscopy. The chemical, crystal, and thermal properties of SLNs were studied by FTIR, XRD analysis, and DSC, respectively. SLNs prepared using different stabilizers showed an encapsulation efficiency of nearly 90% and a drug loading efficiency of 12%. SLNs showed more than 90% of drug released in 72 h and increased with pH was confirmed using in vitro drug release studies. SLNs were nontoxic to raw 264.7 cells. All stabilizers were found suitable for acoustic cavitation-assisted SLN formulation with high encapsulation efficiency and drug loading and good biocompatibility.

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Section: Introductionmentioning

confidence: 99%

Acoustic Cavitation-Assisted Formulation of Solid Lipid Nanoparticles using Different Stabilizers

2019

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“…SLNs have several advantages for drug delivery: they can be produced without using organic solvents, have high physical stability, and enhanced, controlled release of loaded drugs. The major drawbacks of SLNs include limited drug loading efficiency (especially for hydrophilic molecules) due to inflexibility of their shape, and undesired particle growth by agglomeration, which may lead to the burst release of the drug [107][108][109][110].…”

Section: Solid Lipid Nanoparticlesmentioning

confidence: 99%

Nanotherapeutics for Nose-to-Brain Drug Delivery: An Approach to Bypass the Blood Brain Barrier

Lee

Minko

2021

Pharmaceutics

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Treatment of neurodegenerative diseases or other central nervous system (CNS) disorders has always been a significant challenge. The nature of the blood-brain barrier (BBB) limits the penetration of therapeutic molecules to the brain after oral or parenteral administration, which, in combination with hepatic metabolism and drug elimination and inactivation during its journey in the systemic circulation, decreases the efficacy of the treatment, requires high drug doses and often induces adverse side effects. Nose-to-brain drug delivery allows the direct transport of therapeutic molecules by bypassing the BBB and increases drug concentration in the brain. The present review describes mechanisms of nose-to-brain drug delivery and discusses recent advances in this area with especial emphasis on nanotechnology-based approaches.

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“…SLNs are formulated with lipids or lipid mixtures which are in a solid state at room and also at body temperature [41]. Their solid lipid core provides the opportunity for solubilizing Essential oils (stearic acid and palmitic acid; triglycerides, such as tristearin and tripalmitin; partial glycerides, such as glycerylbehenate and glycerylpalmitostearate;) and protect them against degradation [24].…”

Section: Solid-lipid Nanoparticlesmentioning

confidence: 99%

“…Their solid lipid core provides the opportunity for solubilizing Essential oils (stearic acid and palmitic acid; triglycerides, such as tristearin and tripalmitin; partial glycerides, such as glycerylbehenate and glycerylpalmitostearate;) and protect them against degradation [24]. These EOs are physiological substances which are classified as Generally Recognized as Safe (GRAS) category [41]. Compritol®888 ATO, Precirol® ATO5, cetyl alcohol, cetylpalmitate, glycerylmonostearate, trimyristin/Dynasan®114, tristearin/Dynasan® 118, stearic acid, Imwitor®900 are brand names used in formulation of SLNs, and appear to be well tolerated physiologically when administered in vivo [42].…”

Section: Solid-lipid Nanoparticlesmentioning

confidence: 99%

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Lipid Based Drug Delivery System: A Review

Zubair

Sheshe

Bashir

et al. 2021

JALSI

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Associated with the old/traditional of method of drug delivery are several limitation ranging from first-pass effect, low tolerance, minimal bioavailability, fluctuation of plasma drug concentration which result to less or no desired effect produced. This call for the demand for a more efficient drug administration technique. Lipid systems are biocompatible, inert and biodegradable, stable and deliver at the target with the desired effect. This paper attempt to describe several types of lipid particles used to deliver drug compounds and their applications as therapeutic agent in treating different clinical condition.

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Lipid-based nanoparticles for dermal drug delivery

Cited by 18 publications

References 146 publications

Acoustic Cavitation-Assisted Formulation of Solid Lipid Nanoparticles using Different Stabilizers

Acoustic Cavitation-Assisted Formulation of Solid Lipid Nanoparticles using Different Stabilizers

Nanotherapeutics for Nose-to-Brain Drug Delivery: An Approach to Bypass the Blood Brain Barrier

Lipid Based Drug Delivery System: A Review

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