Lipid based nanocarriers system for topical delivery of photosensitizers

Shadab,; Haque, Syed Ehtaishamul; Madheswaran, Thiagarajan; Zeeshan, Farrukh; Meka, Venkata Srikanth; Radhakrishnan, Ammu Kutty; Kesharwani, Prashant

doi:10.1016/j.drudis.2017.04.010

Cited by 54 publications

(31 citation statements)

References 60 publications

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“…As most sensitizing agents, ZnPc belongs to class IV of the biopharmaceutical classification system, characterized by low solubility in water and low permeability. 24 Therefore, ZnPc delivery has to be assisted by formulations that allow proper solubilization of the drug in the biological medium. To avoid the prolonged photosensitivity caused by systemic administration, ZnPc has been proposed for the topical treatment of skin diseases.…”

Section: Introductionmentioning

confidence: 99%

“…25,26 Such topical formulations would permit non-invasive treatment, simple application, easy accessibility of light or ultrasound exposure, and increased drug concentration at the site of the disease, restricting adverse effects to the site of application. 24 In this work, to overcome ZnPc's poor water solubility and enable its topical administration assisted by LFU, we encapsulate ZnPc in nanometric polymeric micelles of 1.2-distearoyl-sn-glyreco-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (DSPE-PEG). DSPE-PEG micelles have shown to be a potential drug carrier, 27 increasing apparent aqueous solubility and enhancing cutaneous penetration of hydrophobic drugs.…”

Section: Introductionmentioning

confidence: 99%

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<p>Bifunctional Therapeutic Application of Low-Frequency Ultrasound Associated with Zinc Phthalocyanine-Loaded Micelles</p>

Martins¹,

Fonseca²,

Pavan³

et al. 2020

IJN

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Purpose: Sonodynamic therapy (SDT) is a new therapeutic modality for the noninvasive cancer treatment based on the association of ultrasound and sonosensitizer drugs. Topical SDT requires the development of delivery systems to properly transport the sonosensitizer, such as zinc phthalocyanine (ZnPc), to the skin. In addition, the delivery system itself can participate in sonodynamic events and influence the therapeutic response. This study aimed to develop ZnPc-loaded micelle to evaluate its potential as a topical delivery system and as a cavitational agent for low-frequency ultrasound (LFU) application with the dual purpose of promoting ZnPc skin penetration and generating reactive oxygen species (ROS) for SDT. Methods: ZnPc-loaded micelles were developed by the thin-film hydration method and optimized using the Quality by Design approach. Micelles' influence on LFU-induced cavitation activity was measured by potassium iodide dosimeter and aluminum foil pits experiments. In vitro skin penetration of ZnPc was assessed after pretreatment of the skin with LFU and simultaneous LFU treatment using ZnPc-loaded micelles as coupling media followed by 6 h of passive permeation of ZnPc-loaded micelles. The singlet oxygen generation by LFU irradiation of the micelles was evaluated using two different hydrophilic probes. The lipid peroxidation of the skin was estimated using the malondialdehyde assay after skin treatment with simultaneous LFU using ZnPc-loaded micelles. The viability of the B16F10 melanoma cell line was evaluated using resazurin after treatment with different concentrations of ZnPc-loaded micelles irradiated or not with LFU. Results: The micelles increased the solubility of ZnPc and augmented the LFU-induced cavitation activity in two times compared to water. After 6 h ZnPc-loaded micelles skin permeation, simultaneous LFU treatment increased the amount of ZnPc in the dermis by more than 40 times, when compared to non-LFU-mediated treatment, and by almost 5 times, when compared to LFU pretreatment protocol. The LFU irradiation of micelles induced the generation of singlet oxygen, and the lipoperoxidation of the skin treated with the simultaneous LFU was enhanced in three times in comparison to the non-LFU-treated skin. A significant reduction in cell viability following treatment with ZnPc-loaded micelles and LFU was observed compared to blank micelles and non-LFU-treated control groups. Conclusion: LFU-irradiated mice can be a potential approach to skin cancer treatment by combining the functions of increasing drug penetration and ROS generation required for SDT.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>Bifunctional Therapeutic Application of Low-Frequency Ultrasound Associated with Zinc Phthalocyanine-Loaded Micelles</p>

Martins¹,

Fonseca²,

Pavan³

et al. 2020

IJN

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show abstract

“…This is due to their improved biocompatibility, enhanced permeability and better entrapment/ encapsulation/loading efficiency, as well as scalability and cost effective manufacturing [14]. These advantages are extremely important in transdermal and oral applications where the surface functionalization by special ligands is not so necessary for effective delivery of the photosensitive compounds [3,15,16]. Nevertheless, in the case of intravenous administration, "soft" colloidal nanosystems obtained by self-assembly of phospholipids or other amphiphilic compounds can be easily functionalized by structural design processes [17,18].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Structural Design of Photosensitive Agent Formulations Using “Soft” Colloidal Nanocarriers

et al. 2020

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The growing demand for effective delivery of photosensitive active compounds has resulted in the development of colloid chemistry and nanotechnology. Recently, many kinds of novel formulations with outstanding pharmaceutical potential have been investigated with an expansion in the design of a wide variety of “soft” nanostructures such as simple or multiple (double) nanoemulsions and lipid formulations. The latter can then be distinguished into vesicular, including liposomes and “smart” vesicles such as transferosomes, niosomes and ethosomes, and non-vesicular nanosystems with solid lipid nanoparticles and nanostructured lipid carriers. Encapsulation of photosensitive agents such as drugs, dyes, photosensitizers or antioxidants can be specifically formulated by the self-assembly of phospholipids or other amphiphilic compounds. They are intended to match unique pharmaceutic and cosmetic requirements and to improve their delivery to the target site via the most common, i.e., transdermal, intravenous or oral administration routes. Numerous surface modifications and functionalization of the nanostructures allow increasing their effectiveness and, consequently, may contribute to the treatment of many diseases, primarily cancer. An increasing article number is evidencing significant advances in applications of the different classes of the photosensitive agents incorporated in the ”soft” colloidal nanocarriers that deserved to be highlighted in the present review.

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“…Thus, it is essential to develop a delivery platform with better biocompatibility and biodegradability. [15][16][17] Polydopamine melanin nanoparticles (PDMNs) are an emerging kind of biomimetic polymer, which keep the natural characteristics of melanin pigment, such as its excellent biocompatibility, water solubility and biodegradability. 18 PDMNs can be applied for photothermal therapy (PTT) due to their high photothermal conversion efficacy.…”

Section: Introductionmentioning

confidence: 99%

Photosensitizer-loaded biomimetic platform for multimodal imaging-guided synergistic phototherapy

et al. 2018

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Lipid based nanocarriers system for topical delivery of photosensitizers

Cited by 54 publications

References 60 publications

<p>Bifunctional Therapeutic Application of Low-Frequency Ultrasound Associated with Zinc Phthalocyanine-Loaded Micelles</p>

<p>Bifunctional Therapeutic Application of Low-Frequency Ultrasound Associated with Zinc Phthalocyanine-Loaded Micelles</p>

Recent Advances in the Structural Design of Photosensitive Agent Formulations Using “Soft” Colloidal Nanocarriers

Photosensitizer-loaded biomimetic platform for multimodal imaging-guided synergistic phototherapy

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