Lipid-based nanocarrier-mediated targeted delivery of celecoxib attenuate severity of ulcerative colitis

Mishra, Rakesh; Ahmad, Anas; Kumar, Ajay; Vyawahare, Akshay; Raza, Syed Shadab; Khan, Rehan

doi:10.1016/j.msec.2020.111103

Cited by 40 publications

(25 citation statements)

References 47 publications

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“…The effect of MES at 12 mg/kg was comparable to celecoxib at 10 mg/kg. As a selective inhibitor of COX-2, celecoxib is prescribed for the management of pain and inflammatory disorders [29,47], and was used as a positive control in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…Defects of epithelial barrier and cryptal glands are strongly implicated in the pathogenesis of colitis, since disruption of barrier integrity facilitates the translocation of lumen bacteria into the mucosa [47,48]. Infiltration of immune cells into the intestinal mucosa in response to insult in the colon is another key feature of colitis [49].…”

Section: Discussionmentioning

confidence: 99%

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Meroterpenoid-Rich Ethanoic Extract of Sargassum macrocarpum Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice

Joung

Cao

Gwon

et al. 2022

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Colitis is a colon mucosal disorder characterized by intestinal damage and inflammation. This current study aimed to evaluate the effect of meroterpenoid-rich ethanoic extract of a brown algae, Sargassum macrocarpum (MES) on dextran sulfate sodium (DSS)-induced colitis in mice and explore the possible mechanisms. Mice were given 4% DSS in drinking water for 7 days to induce colitis, followed by 3 days of regular water. MES (12 mg/kg body weight) or celecoxib (10 mg/kg body weight) was administrated orally to mice on a daily basis during these 10 days. Both MES and celecoxib supplementations significantly attenuated DSS-induced weight loss, shortening of colon length, elevated myeloperoxidase activity as well as histomorphological changes of colon. MES and celecoxib reduced the inflammation level of colon tissue, as indicated by its suppression on a panel of pro-inflammatory cytokines, including interleukin (IL)-1β, IL-17, tumor necrosis factor α, and interferon γ, and a group of inflammatory proteins, including intracellular adhesion molecule 1, vascular adhesion molecule 1, matrix metalloproteinase (MMP)-2, MMP-9, MMP-13, and inducible nitric oxidase. In addition, their administration down-regulated pro-inflammatory cytokines in serum. Moreover, the supplementation of MES suppressed the DSS-induced hyperactivation of Akt, JNK, and NF-κB signaling pathways. Taken together, our results demonstrate that MES ameliorates DSS-induced colitis in mice, suggesting that MES may have therapeutic implications for the treatment of colitis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Meroterpenoid-Rich Ethanoic Extract of Sargassum macrocarpum Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice

Joung

Cao

Gwon

et al. 2022

Foods

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“…These lipids are prepared by using fatty acids, monoglycerides, diglycerides, triglycerides, waxes and steroids, and, depending on the preparation method, they can be used for both hydrophilic and hydrophobic drugs. In addition, to modulate drug release, such systems can protect the drugs from chemical decomposition [ 39 , 45 ]. Considering the limited loading capacity of the drug due to the presence of solid lipids, other SLN systems have been developed containing liquid lipids in a solid lipid matrix stabilized with biocompatible emulsifiers, named nanostructured lipid carriers (NLC).…”

Section: Characteristics Of Lipid Nanocarriersmentioning

confidence: 99%

“…Considering the limited loading capacity of the drug due to the presence of solid lipids, other SLN systems have been developed containing liquid lipids in a solid lipid matrix stabilized with biocompatible emulsifiers, named nanostructured lipid carriers (NLC). The NLC matrices, easily produced and entirely devoid of any organic solvent, are capable of encapsulating large amount of drug, have good long-term storage stability and can be used for oral administration of poorly water-soluble and low-bioavailability drugs [ 45 ]. Figure 1 shows the scheme of the most used lipid nanocarriers and examples of entrapped NSAIDs.…”

Section: Characteristics Of Lipid Nanocarriersmentioning

confidence: 99%

“…In the treatment of ulcerative colitis, a novel biocompatible nanoformulation for Celecoxib has been developed with colon specific characteristic. This NLC formulation has shown favorable characteristics: sustained release of the drug in physiological buffer solution, cytocompatibility for the normal cells, non-toxicity, safe for enteral human use, and cost-effectiveness [ 45 ].…”

Section: Characteristics Of Lipid Nanocarriersmentioning

confidence: 99%

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Photodegradation of Anti-Inflammatory Drugs: Stability Tests and Lipid Nanocarriers for Their Photoprotection

et al. 2021

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The present paper provides an updated overview of the methodologies applied in photodegradation studies of non-steroidal anti-inflammatory drugs. Photostability tests, performed according to international standards, have clearly demonstrated the photolability of many drugs belonging to this class, observed during the preparation of commercial forms, administration or when dispersed in the environment. The photodegradation profile of these drugs is usually monitored by spectrophotometric or chromatographic techniques and in many studies the analytical data are processed by chemometric procedures. The application of multivariate analysis in the resolution of often-complex data sets makes it possible to estimate the pure spectra of the species involved in the degradation process and their concentration profiles. Given the wide use of these drugs, several pharmaceutical formulations have been investigated to improve their photostability in solution or gel, as well as the pharmacokinetic profile. The use of lipid nanocarriers as liposomes, niosomes or solid lipid nanoparticles has demonstrated to both minimize photodegradation and improve the controlled release of the entrapped drugs.

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Selenocoxib-3, a novel anti-inflammatory therapeutic effectively resolves colitis

et al. 2022

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Lipid-based nanocarrier-mediated targeted delivery of celecoxib attenuate severity of ulcerative colitis

Cited by 40 publications

References 47 publications

Meroterpenoid-Rich Ethanoic Extract of Sargassum macrocarpum Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice

Meroterpenoid-Rich Ethanoic Extract of Sargassum macrocarpum Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice

Photodegradation of Anti-Inflammatory Drugs: Stability Tests and Lipid Nanocarriers for Their Photoprotection

Selenocoxib-3, a novel anti-inflammatory therapeutic effectively resolves colitis

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