Selenocoxib-3, a novel anti-inflammatory therapeutic effectively resolves colitis

Kaur, Ramanpreet; Desai, Dhimant; Amin, Shantu; Raza, Kaisar; Bhalla, Aman; Yadav, Pooja; Kaushal, Naveen

doi:10.1007/s11010-022-04532-y

Cited by 6 publications

(3 citation statements)

References 75 publications

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“…It is widely recognized that elevated levels of ROS and reduced antioxidant capacity contribute to ulcerative colitis (UC), so 114 can be considered a suitable alternative agent for its treatment, as it can restore both in vitro and in vivo the balance of the ROS produced in this disease along with the antioxidants better than celecoxib. The likely explanation of the above-mentioned results is the synergistic effect between the redox modulatory antioxidant and anti-inflammatory effects ascribed to Se and the anti-inflammatory activity of the parent drug …”

Section: Selenized Small Molecule Drugsmentioning

confidence: 99%

“…The likely explanation of the above-mentioned results is the synergistic effect between the redox modulatory antioxidant and anti-inflammatory effects ascribed to Se and the antiinflammatory activity of the parent drug. 227 On the other hand, assembling COX-2 and histone deacetylase inhibitors (HDACi) has been proposed to obtain several selenoderivatives of celecoxib for the treatment of acute lymphoblastic leukemia (ALL) (Figure 20). Based on the data, it can be suggested that the chain length may have a significant effect on the antitumoral capacity of the novel hybrid derivatives.…”

Section: Nonsteroidal Anti-inflammatorymentioning

confidence: 99%

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Selenization of Small Molecule Drugs: A New Player on the Board

Morán-Serradilla,

Plano,

Sanmartín

et al. 2024

J. Med. Chem.

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There is an urgent need to develop safer and more effective modalities for the treatment of a wide range of pathologies due to the increasing rates of drug resistance, undesired side effects, poor clinical outcomes, etc. Throughout the years, selenium (Se) has attracted a great deal of attention due to its important role in human health. Besides, a growing body of work has unveiled that the inclusion of Se motifs into a great number of molecules is a promising strategy for obtaining novel therapeutic agents. In the current Perspective, we have gathered the most recent literature related to the incorporation of different Se moieties into the scaffolds of a wide range of known drugs and their feasible pharmaceutical applications. In addition, we highlight different representative examples as well as provide our perspective on Se drugs and the possible future directions, promises, opportunities, and challenges of this ground-breaking area of research. ■ SIGNIFICANCE • Significance: The development of novel compounds for the treatment of numerous pathologies has become a priority due to the lack of effective therapeutic options. • Impact: This work highlights the potential of incorporating Se moieties into the scaffold of several drugs to develop novel safer bioactive compounds. • Innovation: This Perspective discusses the development of selenoderivatives of a wide array of drugs and their biological applications and proposes novel avenues to continue exploring this outstanding research area.

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Section: Selenized Small Molecule Drugsmentioning

confidence: 99%

Section: Nonsteroidal Anti-inflammatorymentioning

confidence: 99%

Selenization of Small Molecule Drugs: A New Player on the Board

Morán-Serradilla,

Plano,

Sanmartín

et al. 2024

J. Med. Chem.

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show abstract

“…2). [26][27][28][29][30][31][32] We initially considered a strategy for synthesizing 3-aroyl-thiourea derivatives by coupling aroyl isothiocyanates with 3-amino-b-lactams. However, the extended reaction times and additional synthetic steps required to obtain 3-urea-b-lactams using the Liptrot method prompted us to explore alternative approaches.…”

Section: Introductionmentioning

confidence: 99%