Lipid-based colloidal carriers for transdermal administration of bioactives

Barbosa, Raquel de Melo; Severino, Patrícia; Finkler, Christine Lamenha Luna; Paula, Eneida de

doi:10.1016/b978-0-12-818433-2.00011-x

Cited by 7 publications

(6 citation statements)

References 91 publications

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“…α-Tocopherol is the main antioxidant in biomembranes and has the dual role of antioxidant, preventing the oxidation of parenteral emulsions, and vitamin. Lipid-based emulsions can be also employed to deliver lipophilic and amphiphilic bioactives and other antioxidants [ 11 , 12 , 26 , 27 , 28 ].…”

Section: Lipid Intake: Health and Nutritional Aspectsmentioning

confidence: 99%

Polyphenolic Antioxidants in Lipid Emulsions: Partitioning Effects and Interfacial Phenomena

Losada‐Barreiro

Paiva‐Martins

2021

Foods

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The autoxidation of lipids in complex systems such as emulsions or biological membranes, although known to occur readily and to be associated with important pathological events, is lacking in quantitative data in spite of the huge efforts that have been made in attempting to unravel the complex mechanisms of lipid oxidation and its inhibition by antioxidants. Lipids are present as oil-in-water emulsions in many foods and pharmaceutical formulations, and the prevalent role of the interfacial region is critical to understand the antioxidant behavior and to correctly interpret antioxidant efficiencies. The aim of this review is to summarize the current knowledge on the chemical fate of antioxidants before they react with peroxyl radicals. Many researchers highlighted the predominant role of interfaces, and although some attempts have been made to understand their role, in most instances, they were essentially qualitative and based on putative hypotheses. It is only recently that quantitative reports have been published. Indeed, knowledge on the effects of relevant experimental variables on the effective concentrations of antioxidants is necessary for a successful design of alternate, effective antioxidative solutions.

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Section: Lipid Intake: Health and Nutritional Aspectsmentioning

confidence: 99%

Polyphenolic Antioxidants in Lipid Emulsions: Partitioning Effects and Interfacial Phenomena

Losada‐Barreiro

Paiva‐Martins

2021

Foods

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“…The presence of polymorph crystals in SLN/NLC's structures provides significant physical and chemical changes in form, solubility, and melting point, affecting properties related to spreadability, encapsulation capacity, product degradation, and consequently, the release profile of the obtained structures [57,58].…”

Section: X-ray Powder Diffraction (Xrd)mentioning

confidence: 99%

Annatto Oil Loaded Nanostructured Lipid Carriers: A Potential New Treatment for Cutaneous Leishmaniasis

et al. 2021

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Annatto (Bixa orellana L.) is extensively used as food pigment worldwide. Recently, several studies have found it to have healing and antioxidant properties, as well as effective action against leishmaniasis. Therefore, the purpose of this study was to incorporate the oil obtained from annatto seeds into a nanostructured lipid carrier (NLC) and evaluate its physicochemical properties and biological activity against Leishmania major. Nanoparticles were prepared by the fusion-emulsification and ultrasonication method, with the components Synperonic™ PE (PL) as the surfactant, cetyl palmitate (CP) or myristyl myristate (MM) as solid lipids, annatto oil (AO) (2% and 4%, w/w) as liquid lipid and active ingredient, and ultra-pure water. Physicochemical and biological characterizations were carried out to describe the NLCs, including particle size, polydispersity index (PDI), and zeta potential (ZP) by dynamic light scattering (DLS), encapsulation efficiency (EE%), thermal behavior, X-ray diffraction (XRD), transmission electron microscopy (TEM), Electron Paramagnetic Resonance (EPR), cytotoxicity on BALB/c 3T3 fibroblasts and immortalized human keratinocyte cells, and anti-leishmaniasis activity in vitro. Nanoparticles presented an average diameter of ~200 nm (confirmed by TEM results), a PDI of less than 0.30, ZP between −12.6 and −31.2 mV, and more than 50% of AO encapsulated in NLCs. Thermal analyses demonstrated that the systems were stable at high temperatures with a decrease in crystalline structure due to the presence of AOs (confirmed by XRD). In vitro, the anti-leishmania test displayed good activity in encapsulating AO against L. major. The results indicate that the oily fraction of Bixa orellana L. in NLC systems should be evaluated as a potential therapeutic agent against leishmaniasis.

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“…[1][2][3] To enhance transdermal permeation, various efforts have been considered and many researchers regard polymeric colloidal carriers as promising vehicles due to their biodegradability and amenable to chemical modification. 4,5 A significant number of efforts have been made toward developing polymeric transdermal drug nanocarriers with chitosan-based nanoparticles have been among the most widely studied-due to bioadhesion combined with permeability enhancing ability of positively charged chitosan. [6][7][8] Promising results with enhanced permeation have also been exhibited by nanovesicles formulated from amphiphilic materials such as alkyl ethers and alkylglyceryl ethers and esters of fatty acid.…”

Section: Introductionmentioning

confidence: 99%

Investigations of amphiphilic butylglyceryl‐functionalized dextran nanoparticles for topical delivery

Bostanudin

Noor

Sahudin

et al. 2020

J of Applied Polymer Sci

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Toward the development of colloidal systems that can enhance transdermal permeation of hydrophilic actives, a material combining the non‐toxic of dextran with alkylglycerols permeation enhancing property has been designed. To this purpose, a range of amphiphilic butylglyceryl dextrans (DEX‐OX4) was synthesized via modification with n‐butylglycidyl ether with a degree of functionalization in the range 6.3%–35.7%. A reduced viscosity and an increased molecular weight of DEX‐OX4 were recorded when compared to the starting material. DEX‐OX4 was formulated into nanocarriers and loaded with α‐arbutin prior to characterization—the nanoparticles (180–220 nm size) were found to be close‐to‐spherical, stable at pH 5 and 7, with a loading capacity of 11.7%. Slower release of α‐arbutin from the nanoparticles was demonstrated when tested in acidic media. Lack of toxicity at application‐relevant concentrations and increased permeation were demonstrated by nanoparticles in vitro results against immortalized skin human keratinocytes cells (HaCaT).

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Lipid-based colloidal carriers for transdermal administration of bioactives

Cited by 7 publications

References 91 publications

Polyphenolic Antioxidants in Lipid Emulsions: Partitioning Effects and Interfacial Phenomena

Polyphenolic Antioxidants in Lipid Emulsions: Partitioning Effects and Interfacial Phenomena

Annatto Oil Loaded Nanostructured Lipid Carriers: A Potential New Treatment for Cutaneous Leishmaniasis

Investigations of amphiphilic butylglyceryl‐functionalized dextran nanoparticles for topical delivery

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