Lipid and Hematological Parameters in Hyperleptinemic Healthy Arab Male Youth in Jordan

Abstract

To analyze the influence ofhyperleptinemia on fasting lipid and hematological parameters in healthy Arab male youth in Jordan, this cross-sectional study was carried out in April 2009 on a sample of 120 students aged 18-24 years. Subjects were stratified by fasting leptin into two groups (control, <12.7 ng mL(-1) vs. hyperleptenimic, e_< 12.7 ng mL(-1)) and BMI (normal weight, < 25 kgm(-2) vs. overweight/obese, BMI e_< 25 kg m(-2)). Fasting serum leptin, blood glucose, lipid profile and hematological parameters values were determined by standard kit methods. Mean serum leptin concentrations were more than five times as high in hyperleptenemic subjects than in control subjects (p < 0.001). Compared with control group, significant elevations (p < 0.01) were observed in the means total cholesterol, LDL cholesterol and triglyceride levels of hyperleptenemic group whereas no significant differences was detected in HDL-cholesterol. Except the changes of WBC count, MCH and slightly MCHC, there were no differences between both groups in any other term of hematological parameters. In conclusion, changes in lipid variables and some hematological parameters may increase plasma viscosity as a step during atherosclerosis pathogenesis in male youth at risk for dyslipidemia and cardiovascular diseases. Thus, hyperleptinemia could be a useful index in identifying healthy youth male subjects but this hypothesis needs further investigation.

Relationship between newborn leptin levels and selected growth parameters

“…Abu-Samak et al. 13 conducted a study to analyze the effect of hyperleptinemia on fasting lipid and hematological parameters in healthy young men in Jordan. These authors found that mean serum leptin levels were higher in those with hyperlipidemia than in those without hyperlipidemia.…”

A Cross-Sectional Study on the Combined Effect of Body Weight and Coffee Consumption on Serum Levels of Leptin, Vitamin B12, and Folic Acid in Healthy Young Adult Males

“…30 Obesity is associated with high levels of leptin, which is considered as an important obesity marker. 31 However, leptin resistance occurs, leading to the inability to reach satiety despite high-energy stores and high levels of leptin. Excess leptin has been associated with many obesityrelated diseases, such as hypertension, cardiovascular diseases, and infertility.…”

“…39,40 Leptin, vitamin B12, and folate play important roles in the development of obesity. 31,[41][42][43] It has been found that overweight young men are more likely to have a risk for vitamin submit your manuscript | www.dovepress.com…”

Comment on: Relationship between lipid and hematological profiles and adiposity in obese adolescents

“…Abu-Samak et al ( 11 ) analyzing healthy Arab male youths in Jordan showed that changes inlipid variables and some hematological parameters may increase plasma viscosity as a step during atherosclerosis pathogenesis in male youths at risk for dyslipidemia and cardiovascular diseases.…”