Lipid and apolipoprotein changes after orthotopic liver transplantation for end-stage liver diseases

Malmendier, Claude; Lontie, Jean-Francois; Mathé, Denis; Adam, René; Bismuth, H

doi:10.1016/0009-8981(92)90165-m

Cited by 17 publications

(19 citation statements)

References 32 publications

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“…4,23,24 Triglyceride levels increased early after OLT, whereas an elevation in total cholesterol and LDL cholesterol was found later in the postoperative course. However, prevalence of lipid metabolism disorders were only comparable to a limited extent because definition of abnormal blood lipid levels and applied immunosuppressive regimens varied between studies.…”

Section: Discussionmentioning

confidence: 94%

Risk Factors of Metabolic Disorders After Liver Transplantation

Gebhardt

Jara²,

Malinowski³

et al. 2015

Transplantation

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Section: Discussionmentioning

confidence: 94%

Risk Factors of Metabolic Disorders After Liver Transplantation

Gebhardt

Jara²,

Malinowski³

et al. 2015

Transplantation

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“…A statistically significant correlation was found between plasma LCAT activities and allograft function in orthotopic liver transplant recipients during the early post-operative period [lo], suggesting that measurement of plasma LCAT activity may be an effective and practical method for assessing early allograft function. Although in the long-term orthotopic liver transplantation can lead to a restoration of cholesterol metabolism in patients with ESLD [8,12,13], in the early postoperative phase decreases in HDL-cholesterol, apo A1 and apo A11 have been observed, whereas triglycerides, apo B, CII and CIII tended to increase during the same period [14]. Although in the long-term orthotopic liver transplantation can lead to a restoration of cholesterol metabolism in patients with ESLD [8,12,13], in the early postoperative phase decreases in HDL-cholesterol, apo A1 and apo A11 have been observed, whereas triglycerides, apo B, CII and CIII tended to increase during the same period [14].…”

Section: Introductionmentioning

confidence: 99%

Relationship of apolipoproteins Al, B and lipoprotein Lp(a) to hepatic function of liver recipients during the early post‐transplant period

Armstrong

Schütz

Luy

et al. 1995

Eur J Clin Investigation

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To evaluate serum apo AI, apo B, Lp(a) and the ratio of unesterified cholesterol to total cholesterol as markers of hepatic synthetic capacity after orthotopic liver transplantation, serial measurements of these variables were performed on post-transplant days 1, 3, 5, 7, 10 and 14 in 70 patients. Liver function was assessed by a quantitative dynamic test based on the hepatic conversion of lidocaine to monoethylglycinexylidide (MEGX). Patients were divided into two groups on the basis of clinical and laboratory findings, those with evidence (n = 46) and those without evidence (n = 24) of hepatic dysfunction. Apo AI levels fell in both groups to day 5, but then began to increase in the group with good hepatic function, a highly significant (P < 0.001) positive correlation being found with the results of the MEGX test on post-transplant days 7, 10 and 14. The ratio of unesterified cholesterol to total cholesterol rose in both groups from days 1 to 7 and then began to fall in the group without hepatic dysfunction; a highly significant (P < 0.001) negative correlation was observed with the results of the MEGX test on days 10 and 14, Apo B levels rose in both groups from days 1 to 10, with no significant differences between the two groups; no correlation was observed with the results of the MEGX test on any study day.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…With the short half-life, changes of the serum apoA-I levels may be a good indicator of the hepatic protein synthesis ability during the perioperative period after hepatectomy (Krempler et al, 1980;Katsuramaki et al, 2002). It also serves as an excellent parameter for predicting liver function after orthotopic liver transplantation (Tietge et al, 1998;Malmendier et al, 1992).…”

Section: Influence Of Liver Cancer On Apoli-poproteinsmentioning

confidence: 99%

Lipids changes in liver cancer

Jiang

Zhang

et al. 2007

J. Zhejiang Univ. - Sci. B

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Abstract:Liver is one of the most important organs in energy metabolism. Most plasma apolipoproteins and endogenous lipids and lipoproteins are synthesized in the liver. It depends on the integrity of liver cellular function, which ensures homeostasis of lipid and lipoprotein metabolism. When liver cancer occurs, these processes are impaired and the plasma lipid and lipoprotein patterns may be changed. Liver cancer is the fifth common malignant tumor worldwide, and is closely related to the infections of hepatitis B virus (HBV) and hepatitis C virus (HCV). HBV and HCV infections are quite common in China and other Southeast Asian countries. In addition, liver cancer is often followed by a procession of chronic hepatitis or cirrhosis, so that hepatic function is damaged obviously on these bases, which may significantly influence lipid and lipoprotein metabolism in vivo. In this review we summarize the clinical significance of lipid and lipoprotein metabolism under liver cancer.

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Lipid and apolipoprotein changes after orthotopic liver transplantation for end-stage liver diseases

Cited by 17 publications

References 32 publications

Risk Factors of Metabolic Disorders After Liver Transplantation

Risk Factors of Metabolic Disorders After Liver Transplantation

Relationship of apolipoproteins Al, B and lipoprotein Lp(a) to hepatic function of liver recipients during the early post‐transplant period

Lipids changes in liver cancer

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