Lipids changes in liver cancer

Abstract

Abstract:Liver is one of the most important organs in energy metabolism. Most plasma apolipoproteins and endogenous lipids and lipoproteins are synthesized in the liver. It depends on the integrity of liver cellular function, which ensures homeostasis of lipid and lipoprotein metabolism. When liver cancer occurs, these processes are impaired and the plasma lipid and lipoprotein patterns may be changed. Liver cancer is the fifth common malignant tumor worldwide, and is closely related to the infections of hepatitis B virus (HBV) and hepatitis C virus (HCV). HBV and HCV infections are quite common in China and other Southeast Asian countries. In addition, liver cancer is often followed by a procession of chronic hepatitis or cirrhosis, so that hepatic function is damaged obviously on these bases, which may significantly influence lipid and lipoprotein metabolism in vivo. In this review we summarize the clinical significance of lipid and lipoprotein metabolism under liver cancer.

Association of Antituberculosis Treatment and Lower Risk of Hyperlipidemia in Taiwanese Patients: A Population-Based Case–Control Study

“…The liver is critical in lipid metabolism. It absorbs serumfree fatty acids and manufactures, stores, and transports lipid metabolites (18). Lipids, mainly TGs, occur in hepatocytes and represent a hallmark feature of the pathogenesis of nonalcoholic fatty liver disease (18).…”

“…It absorbs serumfree fatty acids and manufactures, stores, and transports lipid metabolites (18). Lipids, mainly TGs, occur in hepatocytes and represent a hallmark feature of the pathogenesis of nonalcoholic fatty liver disease (18). The clinical implication of hyperlipidemia or the combination of lipid abnormalities, including high serum LDL-cholesterol, TG, and low serum high density lipoprotein-cholesterol levels.…”

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Correlation between liver cancer occurrence and gene expression profiles in rat liver tissue

“…Moreover, organic acid metabolism was shown by synergy analysis to be significantly lower during the entire tumoriogenesis, which may be caused by the down-regulation of a variety of fatty acid, amino acid metabolism-related genes. Therefore, lipid, amino acid and their derivative, organic acid metabolism were attenuated during the occurrence and development of liver cancer, suggesting that liver injury induced by carcinogenic agent had negative effect on the metabolism of fundamental substances (Jiang et al, 2007).…”