Lipase mediated functionalization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with ascorbic acid into an antioxidant active biomaterial

Bhatia, Shashi Kant; Wadhwa, Puneet; Hong, Ju Won; Hong, Yoon Gi; Jeon, Ji-Hong; Lee, Eui‐Seok; Yang, Yung‐Hun

doi:10.1016/j.ijbiomac.2018.11.052

Cited by 49 publications

(29 citation statements)

References 42 publications

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“…Packaging [5] Sponge cloths [73] Electronics applications [5] Starch-based Films [74] Rigid materials (such as plates and cutlery and foams) [74,75] Packaging [30,75] Medical products [30,75] Agriculture [30,39,76] Carrier bags [16,77] PLA-based Packaging [30,38,74,78] Disposable or durable goods [74] Electronics applications [38] Fibres [38] Medical products [30] Building and construction [78] Agricultural field [30,38] Textiles and films [64] PHA-based Medical products [30,74,[79][80][81][82] Agriculture [30,74] Packaging [30,82] Petroleum-based Medical products [30] Packaging [30] Agriculture [39] As shown in Table 2, bioplastics are used in a wide range of applications. This is attributed to the fact that several desired characteristics can be obtained (such as, flexibility, strength, shape memory capability, or resistance to liquids) by easily changing the processing conditions during their production.…”

Section: Cellulose-basedmentioning

confidence: 99%

Biodegradation of Wasted Bioplastics in Natural and Industrial Environments: A Review

et al. 2020

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The problems linked to plastic wastes have led to the development of biodegradable plastics. More specifically, biodegradable bioplastics are the polymers that are mineralized into carbon dioxide, methane, water, inorganic compounds, or biomass through the enzymatic action of specific microorganisms. They could, therefore, be a suitable and environmentally friendly substitute to conventional petrochemical plastics. The physico-chemical structure of the biopolymers, the environmental conditions, as well as the microbial populations to which the bioplastics are exposed to are the most influential factors to biodegradation. This process can occur in both natural and industrial environments, in aerobic and anaerobic conditions, with the latter being the least researched. The examined aerobic environments include compost, soil, and some aquatic environments, whereas the anaerobic environments include anaerobic digestion plants and a few aquatic habitats. This review investigates both the extent and the biodegradation rates under different environments and explores the state-of-the-art knowledge of the environmental and biological factors involved in biodegradation. Moreover, the review demonstrates the need for more research on the long-term fate of bioplastics under natural and industrial (engineered) environments. However, bioplastics cannot be considered a panacea when dealing with the elimination of plastic pollution.

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Section: Cellulose-basedmentioning

confidence: 99%

Biodegradation of Wasted Bioplastics in Natural and Industrial Environments: A Review

et al. 2020

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“…In order to produce an overall superior PHB material, a number of studies have been conducted aiming to improve the mechanical behavior and reduce the high costs associated with the material production. Some of these approaches are based on the use of blends, the addition of functional groups, copolymer developments and chemical modifications of the material [11][12][13][14][15]. Functionalization of PHA copolymers showed important improvement in the properties and appears to be a very good approach in increasing the applications of PHA materials.…”

Section: Polyhydroxyalkanoates (Phas)mentioning

confidence: 99%

“…Functionalization of PHA copolymers showed important improvement in the properties and appears to be a very good approach in increasing the applications of PHA materials. A recent example is shown by Bhatia et al, where poly-(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), functionalized with ascorbic acid, resulted in a lower degree of crystallinity (9.96%), higher thermal degradation temperature (294.97 • C) and hydrophilicity (showing contact angle of 68 • ) and 1.6 fold increase in biodegradability when compared to the un-functionalized PHBV copolymer [15].…”

Section: Polyhydroxyalkanoates (Phas)mentioning

confidence: 99%

Production of Polyhydroxybutyrate (PHB) and Factors Impacting Its Chemical and Mechanical Characteristics

et al. 2020

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Plastic pollution is fueling the grave environmental threats currently facing humans, the animal kingdom, and the planet. The pursuit of renewable resourced biodegradable materials commenced in the 1970s with the need for carbon neutral fully sustainable products driving important progress in recent years. The development of bioplastic materials is highlighted as imperative to the solutions to our global environment challenges and to the restoration of the wellbeing of our planet. Bio-based plastics are becoming increasingly sustainable and are expected to substitute fossil-based plastics. Bioplastics currently include both, nondegradable and biodegradable compositions, depending on factors including the origins of production and post-use management and conditions. Among the most promising materials being developed and evaluated is polyhydroxybutyrate (PHB), a microbial bioprocessed polyester belonging to the polyhydroxyalkanoate (PHA) family. This biocompatible and non-toxic polymer is biosynthesized and accumulated by a number of specialized bacterial strains. The favorable mechanical properties and amenability to biodegradation when exposed to certain active biological environments, earmark PHB as a high potential replacement for petrochemical based polymers such as ubiquitous high density polyethylene (HDPE). To date, high production costs, minimal yields, production technology complexities, and difficulties relating to downstream processing are limiting factors for its progression and expansion in the marketplace. This review examines the chemical, mechanical, thermal, and crystalline characteristics of PHB, as well as various fermentation processing factors which influence the properties of PHB materials.

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“…Other nanoparticles derived from small molecules such as ascorbic acid (Bhatia et al, 2019), citric acid , and trolox (Wattamwar et al, 2010), in combination with polymeric scaffolds, have also provided us with a powerful arsenal for antioxidant and anti-inflammatory treatment. For instance, a chemically stable antioxidant molecule, citric acid was grafted with polyvinyl alcohol .…”

Section: Other Organic Nanoparticlesmentioning

confidence: 99%

Antioxidant Nanotherapies for the Treatment of Inflammatory Diseases

Chen

et al. 2020

Front. Bioeng. Biotechnol.

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Reactive oxygen species (ROS) are essential in regulating various physiological functions. However, overproduction of ROS is implicated in the pathogenesis of various inflammatory diseases. Antioxidant therapy has thus represented an effective strategy for the treatment of oxidative stress relevant inflammatory diseases. Conventional anti-oxidative agents showed limited in vivo effects owing to their non-specific distribution and low retention in disease sites. Over the past decades, significant achievements have been made in the development of antioxidant nanotherapies that exhibit multiple advantages such as excellent pharmacokinetics, stable anti-oxidative activity, and intrinsic ROS-scavenging properties. This review provides a comprehensive overview on recent advances in antioxidant nanotherapies, including ROS-scavenging inorganic nanoparticles, organic nanoparticles with intrinsic antioxidant activity, and drug-loaded anti-oxidant nanoparticles. We highlight the biomedical applications of antioxidant nanotherapies in the treatment of different inflammatory diseases, with an emphasis on inflammatory bowel disease, cardiovascular disease, and brain diseases. Current challenges and future perspectives to promote clinical translation of antioxidant nanotherapies are also briefly discussed.

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Lipase mediated functionalization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with ascorbic acid into an antioxidant active biomaterial

Cited by 49 publications

References 42 publications

Biodegradation of Wasted Bioplastics in Natural and Industrial Environments: A Review

Biodegradation of Wasted Bioplastics in Natural and Industrial Environments: A Review

Production of Polyhydroxybutyrate (PHB) and Factors Impacting Its Chemical and Mechanical Characteristics

Antioxidant Nanotherapies for the Treatment of Inflammatory Diseases

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