Lipase‐catalyzed ring‐opening polymerization of lactide

Matsumura, Shuichi; Mabuchi, Kimihiro; Toshima, Kazunobu

doi:10.1002/marc.1997.030180604

Cited by 116 publications

(68 citation statements)

References 23 publications

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“…Conversion of lactide to the oligo-and polylactides was determined by comparison of the 1 H NMR spectral integration intensities of the peaks at = 5.0 ppm corresponding to the methine group of the monomeric lactide with the methine proton of the oligo-and polylactides at = 5.2ppm [9,11].…”

Section: Instrumentsmentioning

confidence: 99%

“…By the first report on the lipase catalyzed ring-opening polymerization of lactides by Matsumura, et al. [9], some lipases were used to polymerize In this paper, we are going to report a novel synthesis method to develop the poly(L,L-lactide) by enzymatic ring-opening polymerization by using immobilized lipase CA as a catalyst under a new and the most simple reaction condition from L,L-lactide (Fig. 1).…”

Section: Introductionmentioning

confidence: 99%

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One-pot Enzymatic Synthesis of Poly(L,L-lactide) by Immobilized Lipase Catalyst

et al. 2006

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Abstract:The ring-opening polymerization of L,L-lactide by using immobilized lipase Candida Antarctica (Novozym 435) as a catalyst at a temperature of 100 o C in bulk was conducted. This process was found to yield the corresponding poly(L,L-lactide) (PLLA) with weight-average of molecular weights of about 2,440 and a polydispersity index of 2.63. It was observed that the increase of the reaction time and amount of enzyme catalyst resulted in the polylactides with higher molecular weights.

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Section: Instrumentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

One-pot Enzymatic Synthesis of Poly(L,L-lactide) by Immobilized Lipase Catalyst

et al. 2006

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“…Furthermore, enzymes represent a family of "environmentally friendly" catalysts, because enzymatically polymerized polyesters are potentially biodegradable. Recently, the enzymatic synthesis of lactide has been studied 23) . Polylactide is a biodegradable and bioabsorbable material.…”

Section: Introductionmentioning

confidence: 99%

Lipase-catalyzed ring-opening polymerization of 3(S)-isopropylmorpholine-2,5-dione

Feng

Knüfermann

Klee

et al. 1999

Macromol. Chem. Phys.

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SUMMARY: Lipase-catalyzed ring-opening bulk polymerizations of 3(S)-isopropylmorpholine-2,5-dione (IPMD) were investigated. Selected commercial lipases were screened as catalysts for IPMD polymerization at 100 8C. Polymerizations catalyzed with lipases PPL, PS, and CR result in IPMD conversions of about 50%, and in molecular weights of the products ranging from 3 500 to 17 500. Poly(3-isopropylmorpholine-2,5-dione) has a carboxylic acid group at one end and a hydroxyl group at the other end. During the polymerization, racemization of the valine residue takes place. Lipase PPL was selected for further studies. (ii) increasing reaction temperature leads to a bimodal molecular weight distribution. Water is an important factor that controls not only the conversion but also the molecular weight. With increasing water content, enhanced polymerization rates are achieved while the molecular weight of poly(IPMD) decreases.

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“…To that end, the current microbial cell factory ought to be improved with further evolved LA-polymerizing enzymes (LPE) and metabolic engineering-based optimization (Taguchi, 2010). Matsumura et al (Matsumura et al, 1997) likewise reported the lipase PC-catalyzed polymerization of cyclic diester-D,L-lactide at a temperature of 80-130°C to yield poly(lactic acid) with molecular masses of up to 12,600. Other novel methods (e.g.…”

Section: New Approachesmentioning

confidence: 99%