Lipase-Catalyzed Monostearin Synthesis under Continuous Flow Conditions

Abstract

Biodegradable, biocompatible and nontoxic nonionic surfactants are widely used in food, pharmaceutical and industrial applications being commonly produced based on alkaline-catalyzed chemical glycerolysis of natural oil and fats at high temperatures and elevated pressure under nitrogen atmosphere. In this work we have optimized a biocatalytic continuous flow process with packed bed reactor for the esterification reaction between (R,S)-1,2-isopropylidene glycerol and stearic acid using response surface methodology (RSM) leading to the desired product in excellent conversion (95%) and short reaction time (40 s of residence time).

An imidazolium-based organopalladium-functionalized organic–inorganic hybrid silica promotes one-pot tandem Suzuki cross coupling–reduction of haloacetophenones and arylboronic acids

“…Also, in order to explore its recyclability, another attempt through a continuous-flow synthesis was investigated as shown in Fig. 7 [40]. In this case, 4-iodoacetophenone (1.00 mmol) and phenylboronic acid (1.20 mmol) completely dissolved in a diluted aqueous solution of sodium hydroxide in i-PrOH (20 mL), while the X-Cube (ThalesNano) instrument was equipped with the packed bed reactor containing the heterogeneous catalyst 3 (500 mg of catalyst was filled this bed reactor, 0.6 mL volume, 70 mm × 4 mm).…”

Three Step Chemo Enzymatic Continuous Flow Cascade Synthesis of 1-Monoacylglycerol.

“…Results showed that there was not significative differences on conversions of solketal towards 0,1 (87%) and 0,2 mL/min (86%) of flow.We also investigated the esterification of solketal with stearic acid, applying optimal conditions according to our previous works 3 . Studies of high concentrations of starting material as well as the recycling of biocatalyst(figure 1), demonstrated that 90% of conversion could obtained under 60°C and 0,1mL/min, with 2M of substrates ( figure 1A).…”

Production of Phytosteryl Ester from Echium Oil in a Recirculating Packed Bed Reactor Using an Immobilized Lipase

“…Decrease in the conversion at a retention time of 1 min can be explained by an insufficient retention time as the substrates went through the reactor. Short retention time in the reactor led to a reduction of contact time between the substrates and enzyme, causing insufficient conversion of substrates during the initial reaction time 25,26 .…”