Lipase-catalyzed enantioselective esterifications using different microemulsion-based gels

Backlund, Sune; Eriksson, Folke; Hedström, Gun; Laine, Antti; Rantala, M.

doi:10.1007/bf00655229

Cited by 28 publications

(10 citation statements)

References 54 publications

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“…This supports the previous findings that the SP 525 enzyme is very stereoselective. The enantioselectivity values, E, for this enzyme have been calculated to >150 in all types of gels used by our group (28).…”

Section: Activation Parametersmentioning

confidence: 99%

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Influence of Diffusion on the Kinetics of an Enzyme-Catalyzed Reaction in Gelatin-Based Gels

Hedström

Backlund

Eriksson

2001

Journal of Colloid and Interface Science

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Section: Activation Parametersmentioning

confidence: 99%

“…The gelatin network and water droplets-in-oil coexist independently of each other in the gel. It can also be pointed out that both microemulsions with a bicontinuous structure and liposomes have been used in forming enzyme-containing gels (28,29). The sectioned transparent porous gel is immersed in an alkane containing the substrates.…”

Section: Introductionmentioning

confidence: 99%

Influence of Diffusion on the Kinetics of an Enzyme-Catalyzed Reaction in Gelatin-Based Gels

Hedström

Backlund

Eriksson

2001

Journal of Colloid and Interface Science

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“…Examples of such organogelators) include 12-d-hydroxyoctadecanoic acid (12-HOA), 2 D-homosteroidal nitroxide (SNO), 3 calixarenes, 4 1,3:2,4-di-O-benzylidene-D-sorbitol (D-DBS), 5 ALS compounds (an Aromatic moiety attached by a Linker segment to a Steroidal group), 6 lecithin, 7 bis(2-ethylhexyl) sodium sul-fosuccinate (AOT), 8 gelatin, 9 2,3-bis-n-decyloxyanthracene (DDOA), 10 and some azobenzene cholesterol derivatives. 11 These organogels exhibit interesting properties such as acute temperature/moisture sensitivities, 12,8 the ability to solubilize guest molecules 12 and to act as templates 13 and nonaqueous media for synthesis, [14][15][16][17][18][19] uses for purification and separation purposes, 20 as transdermal delivery vehicles, 21 and as carriers for liquid crystals. 22 Some of these potential applications are discussed in a review by Hinze et al 12 We have previously reported the gelation of certain organic solvents, e.g.…”

Section: Introductionmentioning

confidence: 99%

Novel sorbitan monostearate organogels

Murdan¹,

Gregoriadis²,

Florence³

1999

Journal of Pharmaceutical Sciences

135

104

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Sorbitan monostearate, a hydrophobic nonionic surfactant, gels a number of organic solvents such as hexadecane, isopropyl myristate, and a range of vegetable oils. Gelation is achieved by dissolving/dispersing the organogelator in hot solvent to produce an organic solution/dispersion, which, on cooling sets to the gel state. Cooling the solution/dispersion causes a decrease in the solvent-gelator affinities, such that at the gelation temperature, the surfactant molecules self-assemble into toroidal inverse vesicles. Further cooling results in the conversion of the toroids into rod-shaped tubules. Once formed, the tubules associate with others, and a three-dimensional network is formed which immobilizes the solvent. An organogel is thus formed. Sorbitan monostearate gels are opaque, thermoreversible semisolids, and they are stable at room temperature for weeks. The gels are affected by the presence of additives such as the hydrophilic surfactant, polysorbate 20, which improves gel stability and alters the gel microstructure from a network of individual tubules to star-shaped "clusters" of tubules in the liquid continuous phase. Another solid monoester in the sorbitan ester family, sorbitan monopalmitate, also gels organic solvents to give opaque, thermoreversible semisolids. Like sorbitan monostearate gels, the microstructure of the palmitate gels comprise an interconnected network of rodlike tubules. Unlike the stearate gels, however, the addition of small amounts of a polysorbate monoester causes a large increase in tubular length instead of the "clustering effect" seen in stearate gels. The sorbitan stearate and palmitate organogels may have potential applications as delivery vehicles for drugs and antigens.

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“…Τα πθκτϊματα μικρογαλακτωμάτων ζχουν χρθςιμοποιθκεί ωσ ωορείσ ακινθτοποίθςθσ ενηφμων για τθν επίτευξθ ενηυμικά καταλυόμενων αντιδράςεων ςε μθ ςυμβατικά ςυςτιματα. Τα οργανοπθκτϊματα ωαίνεται να διατθροφν τθ δομι τουσ για μεγάλθ περίοδο, ακόμα και μζςα ςε αυτά τα ςυςτιματα, επιτρζποντασ τθ διάχυςθ μθ πολικϊν υποςτρωμάτων από και προσ το εςωτερικό τουσ (Backlund et al 1996, Rees et al 1991 (Hennrich et al 2006).…”

Section: ακινητοπούηςη ενζύμων ςε οργανοπηκτϐματαunclassified

Μελέτη Της Δομής Και Της Λειτουργίας Υδρολυτικών Ενζύμων Σε Συστήματα Οργανωμένων Νανοδομών

Παυλίδης¹

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Nanostructured systems are of considerable research interest in the field of enzyme biotechnology. The aim of this thesis is to study and understand the structure-function relationship of hydrolytic enzymes in nanostructured systems, leading to the rational design of novel nanobiocatalytic systems. The study focuses on two types of nanostructured systems: water in ionic liquid microemulsions and carbon-based nanomaterials.Water in ionic liquid microemulsions are novel water-nanodispersion systems which combine the advantages of both microemulsions and ionic liquids (IL). Such microemulsions can be formed using the ionic liquid [bmim]PF 6 and the non-ionic surfactant Tween 20. Lipases entrapped in these IL microemulsions exhibited improved catalytic behaviour compared to other microheterogeneous systems, indicating the positive effect of the organized nanostructures on Πύνακασ περιεχομϋνων xiii Πύνακασ περιεχομϋνων ΕΙΑΓΩΓΗ ΘΕΩΡΗΣΙΚΟ ΜΕΡΟ 1 ΕΥΑΡΜΟΓΗ ΤΔΡΟΛΑΩΝ Ε ΒΙΟΚΑΣΑΛΤΣΙΚΕ ΔΙΕΡΓΑΙΕ 1.1 ΒΙΟΚΑΣΑΛΤΗ 1.2 ΤΔΡΟΛΑΕ ΚΑΡΒΟΞΤΛΕΣΕΡΩΝ 1.2.1 Δομό 1.2.2 Καταλυτικόσ μηχανιςμόσ 1.2.3 Μεςεπιφανειακό ενεργοπούηςη λιπαςϐν 2 ΒΙΟΚΑΣΑΛΤΗ Ε ΜΙΚΡΟΓΑΛΑΚΣΩΜΑΣΑ 2.1 ΤΔΑΣΙΚΕ ΝΑΝΟΔΙΑΠΟΡΕ -ΜΙΚΡΟΓΑΛΑΚΣΩΜΑΣΑ 2.2 ΚΑΣΗΓΟΡΙΕ ΜΙΚΡΟΓΑΛΑΚΣΩΜΑΣΩΝ 2.2.1 Μικρογαλακτϐματα νερού ςε ϋλαιο παρουςύα επιφανειενεργού 2.2.2 Μικρογαλακτϐματα νερού ςε ϋλαιο απουςύα επιφανειενεργϐν ενϐςεων 2.2.3 Μικρογαλακτϐματα νερού ςε ιοντικϊ υγρϊ 2.3 ΈΝΖΤΜΑ Ε ΜΙΚΡΟΓΑΛΑΚΣΩΜΑΣΑ 2.4 ΝΑΝOΒΙΟΚΑΣΑΛΤΗ Ε ΤΣΗΜΑΣΑ ΜΙΚΡΟΓΑΛΑΚΣΩΜΑΣΩΝ 3 ΒΙΟΚΑΣΑΛΤΗ Ε ΠΗΚΣΩΜΑΣΑ ΜΙΚΡΟΓΑΛΑΚΣΩΜΑΣΩΝ 3.1 ΠΗΚΣΩΜΑΣΑ ΜΙΚΡΟΓΑΛΑΚΣΩΜΑΣΩΝ -ΟΡΓΑΝΟΠΗΚΣΩΜΑΣΑ 3.2 ΑΚΙΝΗΣΟΠΟΙΗΗ ΕΝΖΤΜΩΝ Ε ΟΡΓΑΝΟΠΗΚΣΩΜΑΣΑ 4 ΝΑΝΟΔΟΜΗΜΕΝΑ ΤΛΙΚΑ 4.1 ΝΑΝΟΒΙΟΣΕΦΝΟΛΟΓΙΑ ΚΑΙ ΝΑΝΟΔΟΜΗΜΕΝΑ ΤΛΙΚΑ 4.2 ΝΑΝΟΫΛΙΚΑ ΒΑΙΜΕΝΑ ΣΟΝ ΑΝΘΡΑΚΑ 4.3 ΟΜΟΙΟΠΟΛΙΚΗ ΣΡΟΠΟΠΟΙΗΗ ΝΑΝΟΔΟΜΗΜΕΝΩΝ ΤΛΙΚΩΝ 4.4 ΙΔΙΟΣΗΣΕ ΝΑΝΟΫΛΙΚΩΝ ΜΕ ΒΑΗ ΣΟΝ ΑΝΘΡΑΚΑ 4.5 ΑΚΙΝΗΣΟΠΟΙΗΗ ΕΝΖΤΜΩΝ Ε ΝΑΝΟΫΛΙΚΑ ΒΑΙΜΕΝΑ Ε ΑΝΘΡΑΚΑ 4.5.1 Προςεγγύςεισ ακινητοπούηςησ 4.5.2 Εφαρμογϋσ ενζύμων ακινητοποιημϋνων ςε νανοώλικϊ με βϊςη τον ϊνθρακα

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Lipase-catalyzed enantioselective esterifications using different microemulsion-based gels

Cited by 28 publications

References 54 publications

Influence of Diffusion on the Kinetics of an Enzyme-Catalyzed Reaction in Gelatin-Based Gels

Influence of Diffusion on the Kinetics of an Enzyme-Catalyzed Reaction in Gelatin-Based Gels

Novel sorbitan monostearate organogels

Μελέτη Της Δομής Και Της Λειτουργίας Υδρολυτικών Ενζύμων Σε Συστήματα Οργανωμένων Νανοδομών

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