Novel sorbitan monostearate organogels

Murdan, Sudaxshina; Gregoriadis, Gregory; Florence, Alexander T.

doi:10.1021/js980342r

Cited by 135 publications

(111 citation statements)

References 23 publications

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“…Organogels were prepared containing 2.5%, 5%, 7.5%, 10%, 15%, and 20% wt/vol of SMS, 5% to 25% wt/vol of distilled water in IM using a method reported by Murdan et al 21 These gels were then checked microscopically for isotropic solution, organogel, and oil/water (o/w) emulsion using a Zeiss universal microscope attached to a digital camera (Oberkochen, Germany). A 7.5% wt/vol of SMS containing 2% wt/vol each, separately, of Tween 20, Tween 60, Tween 80, water (up to 20% wt/vol), and 10% wt/vol of propranolol hydrochloride were prepared in IM.…”

Section: Preformulation Of Gelation Including Effect Of Cosurfactantmentioning

confidence: 99%

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Effect of organogel components on in vitro nasal delivery of propranolol hydrochloride

et al. 2004

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The purpose of this research was to evaluate in vitro transnasal sustained-release ability of sorbitan monostearate (SMS) organogels in isopropyl myristate (IM). Organogels were prepared containing SMS (2.5%-20%) and water (5%-25%) in IM and analyzed microscopically for phase behavior. The effect of Tween surfactants on gel strength and in vitro nasal diffusion of propranolol is reported. The in vitro nasal release retardant effect of SMS and Tween 20 was investigated using factorial design. The microscopic changes in structure of organogel during in vitro nasal diffusion were studied. The water-holding capacity of SMS organogels in IM increased with SMS concentration. The release retardant effect with incorporation of cosurfactant was of the order of Tween 80 > Tween 60 > Tween 20. Gel strengthening and increased viscosity were evident with increased concentration of SMS and Tween 20. The 3-dimensional network of SMS molecules controls the diffusional drug release. The organogel system on nasal mucosa during diffusion is dynamic in nature and changes continuously with the time of diffusion. The water penetration in the organogel network results in percolation and emulsification of organogel, thus affecting the release. Organogels provided an effective barrier for diffusion of propranolol. The surface epithelium lining and the granular cellular structure of treated nasal mucosa were intact.

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Section: Preformulation Of Gelation Including Effect Of Cosurfactantmentioning

confidence: 99%

“…The longer fiber lengths of Tween 60 and Tween 80 can cause increased area of overlap of cross-linking and hence produce higher-strength gels. 21 Tween as cosurfactant participates in micellar gelation of SMS in IM. The longer fiber length of Tween surfactant in SMS gels has a profound effect on flux of drug diffusion.…”

Section: Preformulation Of Organogelationmentioning

confidence: 99%

Effect of organogel components on in vitro nasal delivery of propranolol hydrochloride

et al. 2004

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“…7,8,9? Beyond their use in various applications, in general, aggregated surfactant solutions form a particular class of materials that develop a network of morphological features to retain the solvent. 10,11 For these reasons, the detailed knowledge of MG/oil systems is important both for scientific advancement and technological implementation.…”

Section: Introductionmentioning

confidence: 99%

Aging and Metastability of Monoglycerides in Hydrophobic Solutions

Chen

Terentjev²

2009

Langmuir

125

104

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The aging of aggregated structures of monoglycerides in hydrophobic medium is described by a set of different techniques. Polarized microscopy was used to study the mesomorphic behavior as a function of time. Differential scanning calorimetry was utilized to quantitatively monitor changes in the latent heat in different phase transformations that take place in the aging system. Infrared spectroscopy was applied to detect the formation of hydrogen bonding between surfactants. The X-ray diffraction patterns fingerprinted the molecular arrangement in different emerging phases. Infra-red spectroscopy was used to monitor the state of hydrogen bonding in the system. We conclude that in both inverted-lamellar and sub-alpha crystalline phases, monoglyceride molecules inevitably lose their emulsified ability in the hydrophobic solutions through the gradual change in hydrogen bonding patterns. On aging, the formation of intermolecular hydrogen bonding between glycerol groups causes the segregation of chiral (D and L) isomers within the bilayers. Therefore all structures were eventually forced to reorder into the betacrystalline state, distinguishing between the D and L layers. Accordingly, the highly ordered packing of aged structures weakened the emulsifying ability and finally leaded the collapse of the percolating gel network.

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“…Lipogels are based on fatty components and are obtained by gelling an oily phase with a lipophilic structure, using non-ionic surfactants (22). Generally, they are opaque thermoreversible semisolids that are stable at room temperature for weeks (23).…”

Section: Introductionmentioning

confidence: 99%

Study of In Vitro Drug Release and Percutaneous Absorption of Fluconazole from Topical Dosage Forms

2010

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Abstract. The present study aimed to evaluate different dosage forms, emulsions, emulgels, lipogels, and thickened microemulsion-based hydrogel, as fluconazole topical delivery systems with the purpose of determining a formulation with the capacity to deliver the whole active compound and maintain it within the skin so as to be considered a useful formulation either for topical mycosis treatment or as adjuvant in a combined therapy for Cutaneous Leishmaniasis. Propylene glycol and diethyleneglycol monoethyl ether were used for each dosage form as solvent for the drug and also as penetration enhancers. In vitro drug release after application of a clinically relevant dose of each formulation was evaluated and then microemulsions and lipogels were selected for the in vitro penetration and permeation study. Membranes of mixed cellulose esters and full-thickness pig ear skin were used for the in vitro studies. Candida albicans was used to test antifungal activity. A microemulsion containing diethyleneglycol monoethyl ether was found to be the optimum formulation as it was able to deliver the whole contained dose and enhance its skin penetration. Also this microemulsion showed the best performance in the antifungal activity test compared with the one containing propylene glycol. These results are according to previous reports of the advantages of microemulsions for topical administration and they are very promising for further clinical evaluation.

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Novel sorbitan monostearate organogels

Cited by 135 publications

References 23 publications

Effect of organogel components on in vitro nasal delivery of propranolol hydrochloride

Effect of organogel components on in vitro nasal delivery of propranolol hydrochloride

Aging and Metastability of Monoglycerides in Hydrophobic Solutions

Study of In Vitro Drug Release and Percutaneous Absorption of Fluconazole from Topical Dosage Forms

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