Lip cancer in renal transplant patients

López‐Pintor, Rosa María; Hernández, Gonzalo; Arriba, Lorenzo de; Andrés, Amado

doi:10.1016/j.oraloncology.2010.10.017

Cited by 25 publications

(30 citation statements)

References 28 publications

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“…Among all patients with CKD, RTRs were at higher risk of carcinogenesis than those at pre-transplant stage of CKD [30]. The most crucial factor predisposing to cancer development in RTRs is drug-induced immunosuppression [31]. The risk of carcinogenesis in organ recipients increases with duration and intensity of immunosuppressive therapy, and is inversely related to recipient age [31].…”

Section: Malignancy In the Head And Neck Areamentioning

confidence: 99%

“…The most crucial factor predisposing to cancer development in RTRs is drug-induced immunosuppression [31]. The risk of carcinogenesis in organ recipients increases with duration and intensity of immunosuppressive therapy, and is inversely related to recipient age [31]. Immunosuppression affects tumor immunosurveillance and reduces immunologic control of oncogenic viral infection subsequently leading to cancer development [30].…”

Section: Malignancy In the Head And Neck Areamentioning

confidence: 99%

“…According to various authors, RTRs were more prone to develop LC after transplantation [33,38,39]. LC constituted 5-22.9% of all tumors in RTRs, and affected mainly male recipients [23,31]. The risk of oncogenesis in the lip was higher in RTRs than in patients with CKD on hemodialysis [37].…”

Section: Head and Neck Cancers (Hnc) Potentially Not Related To Viralmentioning

confidence: 99%

“…The majority of LC cases in RTRs were invasive squamous cell carcinomas (SSCs) and were located on the vermilion of the lower lip [31,33,39]. It was suggested that the risk of LP occurrence in RTRs was related to the type and dosage of immunosuppressive drugs, as well as to the therapy timespan [31]. The longer and more aggressive treatment schedule was used, the higher the risk of lip oncogenesis was observed [33,39].…”

Section: Head and Neck Cancers (Hnc) Potentially Not Related To Viralmentioning

confidence: 99%

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Otorhinolaryngological dysfunctions induced by chronic kidney disease in pre- and post-transplant stages

Wojciechowska

Krajewski

Zatoński

2020

Eur Arch Otorhinolaryngol

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Purpose Otorhinolaryngological abnormalities are common complications of chronic kidney disease (CKD) and its treatment. The main aim of this study was to provide a brief and precise review of the current knowledge regarding CKD and its treatment-related influence on head and neck organs. Methods The Medline and Web of Science databases were searched using the terms "chronic kidney disease", "kidney transplantation", "immunosuppression", "dialysis" in conjunction with "otorhinolaryngological manifestation". Articles that did not address the topics, low-quality studies, case reports, and studies based on nonsignificant cohorts were excluded, and the full text of remaining high-quality, novel articles were examined and elaborated on. Results Patients with CKD are prone to develop sensorineural hearing loss, tinnitus, recurrent epistaxis, opportunistic infections including oropharyngeal candidiasis or rhino-cerebral mucormycosis, taste and smell changes, phonatory and vestibular dysfunctions, deep neck infections, mucosal abnormalities, gingival hyperplasia, halitosis or xerostomia. Immunosuppressive therapy after kidney transplantation increases the risk of carcinogenesis, both related and not-related to latent viral infection. The most commonly viral-related neoplasms observed in these patients are oral and oropharyngeal cancers, whereas the majority of not-related to viral infection tumors constitute lip and thyroid cancers. CKD-related otorhinolaryngological dysfunctions are often permanent, difficult to control, have a significant negative influence on patient's quality of life, and can be life threatening. Conclusion Patients with CKD suffer from a number of otorhinolaryngological CKD-induced complications. The relationship between several otorhinolaryngological complications and CKD was widely explained, whereas the correlation between the rest of them and CKD remains unclear. Further studies on this subject are necessary.

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Section: Malignancy In the Head And Neck Areamentioning

confidence: 99%

Section: Malignancy In the Head And Neck Areamentioning

confidence: 99%

Section: Head and Neck Cancers (Hnc) Potentially Not Related To Viralmentioning

confidence: 99%

Section: Head and Neck Cancers (Hnc) Potentially Not Related To Viralmentioning

confidence: 99%

See 2 more Smart Citations

Otorhinolaryngological dysfunctions induced by chronic kidney disease in pre- and post-transplant stages

Wojciechowska

Krajewski

Zatoński

2020

Eur Arch Otorhinolaryngol

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show abstract

“…Kao posljedica interakcije ciklosporina A i blokatora kalcijevih kanala, gotovo redovito se svim bolesnicima koji primaju ovu kombinaciju lijekova pojavljuje hiperplazija gingive (9). Kod osoba s transplantiranim bubregom opisana je pojava raka usnice i usne šupljine (10), a rjeđe poslijetransplantacijski limfoproliferativni poremećaj, oralne ulceracije i lihenoidne reakcije (11). Uz već dokumentirane oralne lezije, opisana je pojava novih entiteta s obilježjima orofacijalne granulomatoze, osobito kod djece s transplantiranim solidnim organom (12).…”

Section: Introductionunclassified