Linum usitatissimum seed mucilage-alginate mucoadhesive microspheres of metformin HCl: Fabrication, characterization and evaluation

Ghumman, Shazia Akram; Noreen, Sobia; Muntaha, Sidra Tul

doi:10.1016/j.ijbiomac.2020.03.181

Cited by 38 publications

(41 citation statements)

References 30 publications

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“…There are many kinds of carrier polymers for biodegradable microspheres, including both natural biodegradable polymers and synthetic ones. Most of the natural polymers come from plants, animals or microorganisms, such as starch (Lin et al, 2013 ; Sommer et al, 2018 ; Tesfay et al, 2020 ), chitosan (Li et al, 2017 ; Calzoni et al, 2019 ; Huang et al, 2019 ; Li et al, 2020 ; Cirri et al, 2021 ), alginate (Campana et al, 2020 ; Ghumman et al, 2020 ; Panchal & Vasava, 2020 ), gelatin (Kim et al, 2018 ; Chen et al, 2019 ; Javanbakht et al, 2019 ), etc. They are used as microsphere carriers due to their rich properties and good biocompatibility (Prajapati et al, 2015 ).…”

Section: Plga As Biodegradable Microsphere Carrier Materialsmentioning

confidence: 99%

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Zhang²,

Sun³

et al. 2021

Drug Delivery

252

106

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Biodegradable microspheres have been widely used in the field of medicine due to their ability to deliver drug molecules of various properties through multiple pathways and their advantages of low dose and low side effects. Poly (lactic-co-glycolic acid) copolymer (PLGA) is one of the most widely used biodegradable material currently and has good biocompatibility. In application, PLGA with a specific monomer ratio (lactic acid and glycolic acid) can be selected according to the properties of drug molecules and the requirements of the drug release rate. PLGA-based biodegradable microspheres have been studied in the field of drug delivery, including the delivery of various anticancer drugs, protein or peptide drugs, bacterial or viral DNA, etc. This review describes the basic knowledge and current situation of PLGA biodegradable microspheres and discusses the selection of PLGA polymer materials. Then, the preparation methods of PLGA microspheres are introduced, including emulsification, microfluidic technology, electrospray, and spray drying. Finally, this review summarizes the application of PLGA microspheres in drug delivery and the treatment of pulmonary and ocularrelated diseases.

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Section: Plga As Biodegradable Microsphere Carrier Materialsmentioning

confidence: 99%

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Zhang²,

Sun³

et al. 2021

Drug Delivery

252

106

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Section: Discussionmentioning

confidence: 98%

“…In this investigation, the system was favored by the mucoadhesive 29 , mucopenetration ability 30 , and biocompatibility of the alginate 31 , increasing the bioavailability of the peptide 32 . Furthermore, previous studies indicate that HPMCAS was able to improve permeation through monolayers of human colon adenocarcinoma cells (Caco-2) and dialysis membranes 33 .…”

Section: Discussionmentioning

confidence: 98%

Application of HPMCAS-coated Ctx(Ile²¹)-Ha peptide microparticles as a potential use to prevent systemic infection caused bySalmonellaEnteritidis in poultry

Roque‐Borda

Saraiva

Monte

et al. 2021

Preprint

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The transmission of Salmonella Enteritidis (SE) in poultry is most often by the fecal-oral route, which can be attributed to the population density. Consequently, the pathogen triggers stress response and virulence factors deploying it to survive in hosts. Therefore, this study proposed to evaluate HPMCAS-coated microparticles containing the Ctx(Ile21)-Ha antimicrobial peptide against SE in laying hens chicks infection model to determine whether Ctx(Ile21)-Ha-utilization confers a benefit in the intestinal lumen, as well as whether limits systemic infection. Importantly, while assessing whether AMP utilization confers reduction of SE in liver, it was noted that there was statistical significance between groups A (control, no Ctx(Ile21)-Ha peptide) and B (2.5 mg of Ctx(Ile21)-Ha/kg) at 2 dpi, potentially indicating the Ctx(Ile21)-Ha effectiveness in the first stage of infection by SE. Remarkably, it was also detected a statistical significance (p -value <0.0001) with lower counts of SE (~ 0 CFU) in livers at 5, 7, and 14 dpi, regardless of Ctx(Ile21)-Ha dosage (2.5 mg or 5 mg/kg - group C). By using Chi-square test, the AMP effect on SE fecal excretion was evaluated. In this regard, it was noticed statistical significance (p < 0.05) among groups B and C in comparison with control group A, since those groups had lower bacterial excretion along 21 days. In summary, the role of HPMCAS-Ctx(Ile21)-Ha peptide microcapsules against S. Enteritidis in laying hen chicks infection model was unraveled, providing a satisfactory results against this pathogen.

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“…The FTIR spectra of pure Alg absorbance bands in 1614 and 1415 cm −1 correspond to the asymmetric and symmetric stretching vibration of C=O groups, respectively. The observed peaks in 1080 cm −1 and 1030 cm −1 are assigned to C-O-C bands vibrations [30,[34][35][36]. The phosphate absorption bands in the FTIR spectrum of nHA are identified by peaks at 472.9, 560, 603.5, 962, 1029, and 1092 cm −1 and two weak carbonate bands are observed at 1416 and 1456 cm −1 for nHA.…”

Section: Ftir Spectroscopymentioning

confidence: 92%

Fabrication and Characterization of Nanocomposite Hydrogel Based on Alginate/Nano-Hydroxyapatite Loaded with Linum usitatissimum Extract as a Bone Tissue Engineering Scaffold

et al. 2021

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In the current paper, we fabricated, characterized, and applied nanocomposite hydrogel based on alginate (Alg) and nano-hydroxyapatite (nHA) loaded with phenolic purified extracts from the aerial part of Linum usitatissimum (LOH) as the bone tissue engineering scaffold. nHA was synthesized based on the wet chemical technique/precipitation reaction and incorporated into Alg hydrogel as the filler via physical cross-linking. The characterizations (SEM, DLS, and Zeta potential) revealed that the synthesized nHA possess a plate-like shape with nanometric dimensions. The fabricated nanocomposite has a porous architecture with interconnected pores. The average pore size was in the range of 100–200 µm and the porosity range of 80–90%. The LOH release measurement showed that about 90% of the loaded drug was released within 12 h followed by a sustained release over 48 h. The in vitro assessments showed that the nanocomposite possesses significant antioxidant activity promoting bone regeneration. The hemolysis induction measurement showed that the nanocomposites were hemocompatible with negligible hemolysis induction. The cell viability/proliferation confirmed the biocompatibility of the nanocomposites, which induced proliferative effects in a dose-dependent manner. This study revealed the fabricated nanocomposites are bioactive and osteoactive applicable for bone tissue engineering applications.

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Linum usitatissimum seed mucilage-alginate mucoadhesive microspheres of metformin HCl: Fabrication, characterization and evaluation

Cited by 38 publications

References 30 publications

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Application of HPMCAS-coated Ctx(Ile²¹)-Ha peptide microparticles as a potential use to prevent systemic infection caused bySalmonellaEnteritidis in poultry

Fabrication and Characterization of Nanocomposite Hydrogel Based on Alginate/Nano-Hydroxyapatite Loaded with Linum usitatissimum Extract as a Bone Tissue Engineering Scaffold

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Linum usitatissimum seed mucilage-alginate mucoadhesive microspheres of metformin HCl: Fabrication, characterization and evaluation

Cited by 38 publications

References 30 publications

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Application of HPMCAS-coated Ctx(Ile21)-Ha peptide microparticles as a potential use to prevent systemic infection caused bySalmonellaEnteritidis in poultry

Fabrication and Characterization of Nanocomposite Hydrogel Based on Alginate/Nano-Hydroxyapatite Loaded with Linum usitatissimum Extract as a Bone Tissue Engineering Scaffold

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Application of HPMCAS-coated Ctx(Ile²¹)-Ha peptide microparticles as a potential use to prevent systemic infection caused bySalmonellaEnteritidis in poultry