Links between celiac disease and small intestinal bacterial overgrowth: A systematic review and meta‐analysis

Shah, Ayesha; Thite, Parag; Hansen, Teressa; Kendall, Bradley J.; Sanders, David S.; Morrison, Mark; Jones, Michael P.; Holtmann, Gerald

doi:10.1111/jgh.15920

Cited by 11 publications

(9 citation statements)

References 43 publications

(86 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An important question is how the course of the underlying disease will respond to SIBO treatment. These results have already been obtained for some diseases[ 49 , 154 ], but their presentation is the aim for the next review.…”

Section: Sibo and Other Diseases: Common Patternsmentioning

confidence: 71%

“…There were no significant differences in the degree of intestinal damage as measured by histology or celiac serology between patients with celiac disease with and without SIBO. Patients with celiac disease and SIBO tended to be older and have more severe signs of malabsorption (lower hemoglobin, serum beta-carotene, albumin levels, and higher fecal fat level), compared with those without SIBO[ 49 ]. SIBO was present in 67% of celiac patients with persistence of gastrointestinal symptoms who had histological response to a gluten-free diet[ 50 ].…”

Section: Organic Gut Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology of small intestinal bacterial overgrowth

Efremova,

Maslennikov,

Poluektova

et al. 2023

World J Gastroenterol

View full text Add to dashboard Cite

Small intestinal bacterial overgrowth (SIBO) is defined as an increase in the bacterial content of the small intestine above normal values. The presence of SIBO is detected in 33.8% of patients with gastroenterological complaints who underwent a breath test, and is significantly associated with smoking, bloating, abdominal pain, and anemia. Proton pump inhibitor therapy is a significant risk factor for SIBO. The risk of SIBO increases with age and does not depend on gender or race. SIBO complicates the course of a number of diseases and may be of pathogenetic significance in the development of their symptoms. SIBO is significantly associated with functional dyspepsia, irritable bowel syndrome, functional abdominal bloating, functional constipation, functional diarrhea, short bowel syndrome, chronic intestinal pseudo-obstruction, lactase deficiency, diverticular and celiac diseases, ulcerative colitis, Crohn’s disease, cirrhosis, metabolic-associated fatty liver disease (MAFLD), primary biliary cholangitis, gastroparesis, pancreatitis, cystic fibrosis, gallstone disease, diabetes, hypothyroidism, hyperlipidemia, acromegaly, multiple sclerosis, autism, Parkinson’s disease, systemic sclerosis, spondylarthropathy, fibromyalgia, asthma, heart failure, and other diseases. The development of SIBO is often associated with a slowdown in orocecal transit time that decreases the normal clearance of bacteria from the small intestine. The slowdown of this transit may be due to motor dysfunction of the intestine in diseases of the gut, autonomic diabetic polyneuropathy, and portal hypertension, or a decrease in the motor-stimulating influence of thyroid hormones. In a number of diseases, including cirrhosis, MAFLD, diabetes, and pancreatitis, an association was found between disease severity and the presence of SIBO. Further work on the effect of SIBO eradication on the condition and prognosis of patients with various diseases is required.

show abstract

Section: Sibo and Other Diseases: Common Patternsmentioning

confidence: 71%

Section: Organic Gut Diseasesmentioning

confidence: 99%

Epidemiology of small intestinal bacterial overgrowth

Efremova,

Maslennikov,

Poluektova

et al. 2023

World J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…Celiac disease (CeD) is an autoimmune enteropathy triggered by gluten ingestion in genetically susceptible individuals [80]. The link between SIBO and CeD seems quite apparent: intestinal dysbiosis can affect gastrointestinal motility and vice versa [81]. Such a correlation was observed in an earlier study [82].…”

Section: Celiac Disease (Ced)mentioning

confidence: 86%

Small Intestinal Bacterial Overgrowth (SIBO) and Twelve Groups of Related Diseases—Current State of Knowledge

Roszkowska,

Klimczak,

Ostrycharz

et al. 2024

Biomedicines

View full text Add to dashboard Cite

The human gut microbiota creates a complex microbial ecosystem, characterized by its high population density, wide diversity, and complex interactions. Any imbalance of the intestinal microbiome, whether qualitative or quantitative, may have serious consequences for human health, including small intestinal bacterial overgrowth (SIBO). SIBO is defined as an increase in the number of bacteria (103–105 CFU/mL), an alteration in the bacterial composition, or both in the small intestine. The PubMed, Science Direct, Web of Science, EMBASE, and Medline databases were searched for studies on SIBO and related diseases. These diseases were divided into 12 groups: (1) gastrointestinal disorders; (2) autoimmune disease; (3) cardiovascular system disease; (4) metabolic disease; (5) endocrine disorders; (6) nephrological disorders; (7) dermatological diseases; (8) neurological diseases (9); developmental disorders; (10) mental disorders; (11) genetic diseases; and (12) gastrointestinal cancer. The purpose of this comprehensive review is to present the current state of knowledge on the relationships between SIBO and these 12 disease groups, taking into account risk factors and the causal context. This review fills the evidence gap on SIBO and presents a biological–medical approach to the problem, clearly showing the groups and diseases having a proven relationship with SIBO, as well as indicating groups within which research should continue to be expanded.

show abstract

“…Celiac disease (CeD) is an autoimmune enteropathy triggered by gluten ingestion in genetically susceptible individuals [79]. The link between SIBO and celiac disease seems quite apparent: intestinal dysbiosis can affect gastrointestinal motility and vice versa [80]. Such a correlation was observed as early as 1970 [81,82].…”

Section: Celiac Disease (Ced)mentioning

confidence: 99%

Small Intestinal Bacterial Overgrowth (SIBO) and Twelve Groups of Diseases Related- Current State of Knowledge

Roszkowska,

Klimczak,

Ostrycharz

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Links between celiac disease and small intestinal bacterial overgrowth: A systematic review and meta‐analysis

Abstract: and the Gastro-Liga, Germany. He has a patent for the Brisbane aseptic biopsy device and serves as Editor of the Gastro-Liga Newsletter. MM serves on the scientific advisory

Cited by 11 publications

References 43 publications

Epidemiology of small intestinal bacterial overgrowth

Epidemiology of small intestinal bacterial overgrowth

Small Intestinal Bacterial Overgrowth (SIBO) and Twelve Groups of Related Diseases—Current State of Knowledge

Small Intestinal Bacterial Overgrowth (SIBO) and Twelve Groups of Diseases Related- Current State of Knowledge

Contact Info

Product

Resources

About