Linking Zinc and Leptin in Chronic Kidney Disease: Future Directions

Lobo, Julie Calixto; Aranha, Luciana Nicolau; Moraes, Cristiane; Brito, Luciana Catunda; Mafra, Denise

doi:10.1007/s12011-011-9211-x

Cited by 6 publications

(3 citation statements)

References 47 publications

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“…Additionally, Zn affects the secretion of leptin [ 160 ]. Zn deficiency increases the level of leptin in patients [ 161 ], which affects the appetite of patients, and may lead to anorexia [ 162 ]. Zn supplementation can improve taste abnormalities of dialysis patients [ 163 ], and increase dietary intake and weight of patients [ 164 ].…”

Section: Advances In Research On Trace Elements and Malnutritionmentioning

confidence: 99%

Progress in the study of nutritional status and selenium in dialysis patients

et al. 2023

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Malnutrition is very common in patients with chronic kidney disease, especially in those on maintenance dialysis. Malnutrition is one of the major factors affecting survival and death of dialysis patients, and reducing their activity tolerance and immunity. There are numerous and interacting risk factors for malnutrition, such as reduced nutritional intake, increased energy expenditure, hormonal disorders, and inflammation. Selenium, in the form of selenoproteins, is involved in many physiological processes in the body and plays an important role in maintaining redox homeostasis. Oxidative stress and infection are very common in dialysis patients, and selenium levels in dialysis patients are significantly lower than those in the healthy population. It has been shown that there is a correlation between selenium levels in hemodialysis patients and their nutrition-related indicators, and that selenium supplementation may improve malnutrition in patients. However, further studies are needed to support this conclusion and there is a lack of basic research to further characterize the potential mechanisms by which selenium may improve malnutrition in dialysis patients. The purpose of this review is to provide a comprehensive overview of factors associated with malnutrition in dialysis patients and to describe the progress of research on nutritional status and selenium levels in dialysis patients.

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Section: Advances In Research On Trace Elements and Malnutritionmentioning

confidence: 99%

Progress in the study of nutritional status and selenium in dialysis patients

et al. 2023

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“…Some patients reported they neglected their health because, aware or not of their problem, they minimized comorbidities, not meeting the guidelines or even denying the warning that the situation was serious and that it could worsen: I did not take high blood pressure The most common gastrointestinal manifestations are nausea, abdominal pain, vomiting, and dysphagia (12) . Some complain about a metallic taste and have ammonia breath odor that can be caused by zinc deficiency and metabolic disorders (13) . Cardiovascular and lung symptoms, with their consequences, especially on fluid overload, dyspnea and edema, were remarkable: ...My feet were always swollen, I urinated less and less, until there was no more urine, I had high blood pressure... (i7).…”

Section: From the Silence Of The Disease To The Classical Clinical Pi...mentioning

confidence: 99%

The chronic renal disease course: from early symptons to discovery

Fortes¹,

Bettinelli²,

Pomatti³

et al. 2013

Rev Rene

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An exploratory and descriptive study with a qualitative approach aim at understanding the significance of the discovery of chronic kidney disease and the need for the hemodialysis machine. The research was made with twenty patients from two hemodialysis services of the city of RS. The data collection took place between September and December of 2007, throughout semi-structured interviews. The thematic analysis generated the following categories: history of chronic kidney disease, from the silence of the disease to the classical clinical symptoms; the discovery and its immediate effects; life after the discovery; acceptance of the dependence on a machine. We conclude that there is a need to adapt the daily life of patients with chronic kidney disease, because the hemodialysis causes physical and social changes, requiring support from health-team to manage the disease. The professional should not abdicate knowledge, safety and technical skill, as requirements to care.

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“…According to previous studies, zinc supplementation has a controversial effect on serum leptin levels. Zinc is connected to insulin signaling and in some situations like obesity and end-stage renal disease [24][25][26][27][28]. So far, zinc has been widely studied for its therapeutic and preventive features and its association with serum leptin level is investigated in several studies.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Zinc Supplementation on Serum Leptin Levels: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2019

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AbSTR Ac TRecently, obesity has become a common worldwide concern. Leptin, as an adipocytokine, plays a major role in the etiology of obesity. Prior studies have demonstrated that zinc potentially affects serum leptin levels. However, clinical trials carried out in this regard are not consistent. Therefore, current meta-analysis was conducted to ascertain the actual effect of zinc supplementation on serum leptin levels in adults. Databases of PubMed, SCOPUS, and Google Scholar were methodically searched to identify relevant articles up to April 2018. Clinical trials that examined the effect of zinc supplementation on serum leptin concentrations as outcome variables in human adults were included. The mean difference (SD) of leptin changes in the intervention and placebo groups were used to calculate the overall effect size. Totally, 663 articles were identified, of which 6 studies were eligible randomized controlled trials (RCTs) with 7 treatment arms. The analysis suggested that zinc supplementation exerts no significant effect on overall serum leptin (WMD: 0.74 ng/ml; 95 % CI: − 1.39 to 2.87, p = 0.49). Nevertheless, sex and duration of intervention seemed to impact the extent of zinc's influence. In trials with female subjects, zinc consumption led to a significant decrease in serum leptin level (WMD: − 1.93 ng/ml; 95 % CI: − 3.72 to − 0.14, p = 0.03) as well as trials that lasted for more than 6 weeks (WMD: − 1.71 ng/ml; 95 % CI: − 3.07 to − 0.35, p = 0.01), in comparison to the control group. Zinc supplementation did not significantly improve leptin concentrations, but it may result in a decreased circulating leptin level in studies with a duration of more than 6 weeks especially among females.

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Linking Zinc and Leptin in Chronic Kidney Disease: Future Directions

Cited by 6 publications

References 47 publications

Progress in the study of nutritional status and selenium in dialysis patients

Progress in the study of nutritional status and selenium in dialysis patients

The chronic renal disease course: from early symptons to discovery

The Effect of Zinc Supplementation on Serum Leptin Levels: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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