Linking Puberty and the Gut Microbiome to the Pathogenesis of Neurodegenerative Disorders

Esposito, Pasquale; Ismail, Nafissa

doi:10.3390/microorganisms10112163

Cited by 7 publications

(4 citation statements)

References 229 publications

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“…Animal and human studies have demonstrated a clear correlation between altered microbial composition and altered behavior [164][165][166][167][168][169][170][171][172], mental disorders [173][174][175], and the development of neuroinflammation [158,[176][177][178][179][180][181]. The intestinal microbiota communicate with the brain via the neural, immune, and metabolic pathways and impact neuronal plasticity and cognition [66,182,183]. This communication takes place either directly via the vagus nerve or indirectly via microbial-derived metabolites, as well as intestinal-derived metabolites, intestinal-derived hormones, and endocrine peptides [3,184].…”

Section: Dysbiosis Behavior Mental Disorders and Neuroinflammationmentioning

confidence: 99%

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Prophylactic Effect of Bovine Colostrum on Intestinal Microbiota and Behavior in Wild-Type and Zonulin Transgenic Mice

et al. 2022

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The microbiota–gut–brain axis (MGBA) involves bidirectional communication between intestinal microbiota and the gastrointestinal (GI) tract, central nervous system (CNS), neuroendocrine/neuroimmune systems, hypothalamic–pituitary–adrenal (HPA) axis, and enteric nervous system (ENS). The intestinal microbiota can influence host physiology and pathology. Dysbiosis involves the loss of beneficial microbial input or signal, diversity, and expansion of pathobionts, which can lead to loss of barrier function and increased intestinal permeability (IP). Colostrum, the first milk from mammals after birth, is a natural source of nutrients and is rich in oligosaccharides, immunoglobulins, growth factors, and anti-microbial components. The aim of this study was to investigate if bovine colostrum (BC) administration might modulate intestinal microbiota and, in turn, behavior in two mouse models, wild-type (WT) and Zonulin transgenic (Ztm)—the latter of which is characterized by dysbiotic microbiota, increased intestinal permeability, and mild hyperactivity—and to compare with control mice. Bioinformatics analysis of the microbiome showed that consumption of BC was associated with increased taxonomy abundance (p = 0.001) and diversity (p = 0.004) of potentially beneficial species in WT mice and shifted dysbiotic microbial community towards eubiosis in Ztm mice (p = 0.001). BC induced an anxiolytic effect in WT female mice compared with WT female control mice (p = 0.0003), and it reduced anxiogenic behavior in Ztm female mice compared with WT female control mice (p = 0.001), as well as in Ztm male mice compared with WT BC male mice (p = 0.03). As evidenced in MGBA interactions, BC supplementation may well be applied for prophylactic approaches in the future. Further research is needed to explore human interdependencies between intestinal microbiota, including eubiosis and pathobionts, and neuroinflammation, and the potential value of BC for human use. The MGH Institutional Animal Care and Use Committee authorized the animal study (2013N000013).

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Section: Dysbiosis Behavior Mental Disorders and Neuroinflammationmentioning

confidence: 99%

“…Overall, research suggests that dysbiosis of the intestinal microbiota and increased intestinal permeability (commonly, but not exclusively, due to dysbiosis) can affect brain function, mental health, and behavior [3,16,31,35,[57][58][59][60][61][62][63][64][65][66].…”

Section: Introductionmentioning

confidence: 99%

Prophylactic Effect of Bovine Colostrum on Intestinal Microbiota and Behavior in Wild-Type and Zonulin Transgenic Mice

et al. 2022

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“…The effect of LPS treatment on increasing inflammatory cytokine levels shortly after exposure in the serum and tissues has been reported [6,57]. A difference in the acute immune responses to LPS exposure has been found between puberty and adulthood, indicating that immune responses to immune stressors are highly affected by age [58]. We found that prebiotic administration diminished the immediate effects of pubertal LPS exposure on IL-17A and F, TGF-β, IL-6, IL-1β, and IL-23.…”

Section: Discussionmentioning

confidence: 99%

Lentinula edodes Cultured Extract and Rouxiella badensis subsp. acadiensis (Canan SV-53) Intake Alleviates Immune Deregulation and Inflammation by Modulating Signaling Pathways and Epigenetic Mechanisms

Shahbazi,

Yasavoli-Sharahi,

Alsadi

et al. 2023

IJMS

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Puberty is a critical developmental period of life characterized by marked physiological changes, including changes in the immune system and gut microbiota development. Exposure to inflammation induced by immune stressors during puberty has been found to stimulate central inflammation and lead to immune disturbance at distant sites from the gut; however, its enduring effects on gut immunity are not well explored. Therefore, in this study, we used a pubertal lipopolysaccharides (LPS)-induced inflammation mouse model to mimic pubertal exposure to inflammation and dysbiosis. We hypothesized that pubertal LPS-induced inflammation may cause long-term dysfunction in gut immunity by enduring dysregulation of inflammatory signaling and epigenetic changes, while prebiotic/probiotic intake may mitigate the gut immune system deregulation later in life. To this end, four-week-old female Balb/c mice were fed prebiotics/probiotics and exposed to LPS in the pubertal window. To better decipher the acute and enduring immunoprotective effects of biotic intake, we addressed the effect of treatment on interleukin (IL)-17 signaling related-cytokines and pathways. In addition, the effect of treatment on gut microbiota and epigenetic alterations, including changes in microRNA (miRNA) expression and DNA methylation, were studied. Our results revealed a significant dysregulation in selected cytokines, proteins, and miRNAs involved in key signaling pathways related to IL-17 production and function, including IL-17A and F, IL-6, IL-1β, transforming growth factor-β (TGF-β), signal transducer and activator of transcription-3 (STAT3), p-STAT3, forkhead box O1 (FOXO1), and miR-145 in the small intestine of adult mice challenged with LPS during puberty. In contrast, dietary interventions mitigated the lasting adverse effects of LPS on gut immune function, partly through epigenetic mechanisms. A DNA methylation analysis demonstrated that enduring changes in gut immunity in adult mice might be linked to differentially methylated genes, including Lpb, Rorc, Runx1, Il17ra, Rac1, Ccl5, and Il10, involved in Th17 cell differentiation and IL-17 production and signaling. In addition, prebiotic administration prevented LPS-induced changes in the gut microbiota in pubertal mice. Together, these results indicate that following a healthy diet rich in prebiotics and probiotics is an optimal strategy for programming immune system function in the critical developmental windows of life and controlling inflammation later in life.

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“…The microbiome has the ability to influence host stress responses by interacting with the neuroendocrine system and the hypothalamic-pituitary-adrenal (HPA) axis [160,161]. Commensal microorganisms can impact the production and signaling of stress hormones, which ultimately affect immune function and susceptibility to infections [162].…”

Section: Microbiome-induced Changes In Host Barrier Permeabilitymentioning

confidence: 99%

Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

Kamel,

Aleya,

Alsubih

et al. 2024

JPM

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Infectious diseases have long posed a significant threat to global health and require constant innovation in treatment approaches. However, recent groundbreaking research has shed light on a previously overlooked player in the pathogenesis of disease—the human microbiome. This review article addresses the intricate relationship between the microbiome and infectious diseases and unravels its role as a crucial mediator of host–pathogen interactions. We explore the remarkable potential of harnessing this dynamic ecosystem to develop innovative treatment strategies that could revolutionize the management of infectious diseases. By exploring the latest advances and emerging trends, this review aims to provide a new perspective on combating infectious diseases by targeting the microbiome.

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Linking Puberty and the Gut Microbiome to the Pathogenesis of Neurodegenerative Disorders

Cited by 7 publications

References 229 publications

Prophylactic Effect of Bovine Colostrum on Intestinal Microbiota and Behavior in Wild-Type and Zonulin Transgenic Mice

Prophylactic Effect of Bovine Colostrum on Intestinal Microbiota and Behavior in Wild-Type and Zonulin Transgenic Mice

Lentinula edodes Cultured Extract and Rouxiella badensis subsp. acadiensis (Canan SV-53) Intake Alleviates Immune Deregulation and Inflammation by Modulating Signaling Pathways and Epigenetic Mechanisms

Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

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