Linking flowability and granulometry of lactose powders

Boschini, Frèdéric; Delaval, Vincent; Traina, Karl; Vandewalle, Nicolas; Lumay, Geoffroy

doi:10.1016/j.ijpharm.2015.08.030

Cited by 37 publications

(19 citation statements)

References 28 publications

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“…Both of the investigated powders have a fair flowability (see Table 2 and [31]). In the absence of vibrations of the dosing unit, powder is not dispensed due to bridging (powder I: ℎ…”

Section: Resultsmentioning

confidence: 95%

Continuous feeding of low-dose APIs via periodic micro dosing

Besenhard

Karkala

Faulhammer

et al. 2016

International Journal of Pharmaceutics

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Precise and effective feeding of small powder quantities remains a challenge in many fields, including pharmaceutical development and production. This paper demonstrates that a simple feeding principle can be applied to accomplish stable micro feeding (<100mg/s) and describes a gravimetric powder feeding system with a vibratory sieve mounted on a chute. Feeding was induced via vertical vibrations that can be adjusted within a broad range of frequencies and amplitudes. The feeding system was studied using different frequencies, amplitudes, sieves and powder properties. Feeding was characterized by means of a dynamic scale and high-speed camera recordings. The feeding system provided effective powder feeding even in a range of 1-2mg/s. It was shown that powder properties require special attention when the vibratory sieve-chute system operates at higher feed rates (or feeding times >30min), i.e., feeding at a higher throughput. A combination of discrete element method (DEM) simulations and compartment population balance model (PBM) was used to incorporate the proposed micro feed system into a continuous powder mixer (Gerike GCM250; Gerike Holding LTD., Regensdorf, Switzerland). It illustrates how oscillating feeding rates (the latter is a characteristic of the studied micro feeding system) affect the content uniformity of low dose blends, i.e., powder mixtures with a relatively low fraction of active pharmaceutical ingredient.

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“…Both of the investigated powders have a fair flowability (see Table 2 and [31]). In the absence of vibrations of the dosing unit, powder is not dispensed due to bridging (powder I: ℎ…”

Section: Resultsmentioning

confidence: 95%

Continuous feeding of low-dose APIs via periodic micro dosing

Besenhard

Karkala

Faulhammer

et al. 2016

International Journal of Pharmaceutics

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“…These results suggest that lactose-based fillers may have unpredictable compression behavior, giving more deviations when lubricated. 16,17 As seen in the stress-strain curve, the variation in deformation of both formulations with similar tableting parameters may have many reasons. A factor that may give rise to these variations is density distribution in the tablets as a result of stress transmission, which is dependent on internal friction, contact powder, and lubrication.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Compressibility Characteristics of Paracetamol using “Compaction Simulator”

Ozalp

Chunu

Jiwa

2020

tjps

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“…The cohesive index quantifies the extent of deviation from an ideal conically shaped heap Powder rheometer; Granular material heap analyzer [107,108] Internal and wall friction Effective angle of internal friction influences many aspects related to flow behavior, e.g., risk of arching and risk of segregation due to unwanted flow patterns; The higher the wall friction angle the more difficult it is to move the powder along the wall surface (the worse the flowability)…”

Section: Powder Characterizationmentioning

confidence: 99%

Continuous Formulation Approaches of Amorphous Solid Dispersions: Significance of Powder Flow Properties and Feeding Performance

et al. 2019

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Preparation and formulation of amorphous solid dispersions (ASDs) are becoming more and more popular in the pharmaceutical field because the dissolution of poorly water-soluble drugs can be effectively improved this way, which can lead to increased bioavailability in many cases. During downstream processing of ASDs, technologists need to keep in mind both traditional challenges and the newest trends. In the last decade, the pharmaceutical industry began to display considerable interest in continuous processing, which can be explained with their potential advantages such as smaller footprint, easier scale-up, and more consistent product, better quality and quality assurance. Continuous downstream processing of drug-loaded ASDs opens new ways for automatic operation. Therefore, the formulation of poorly water-soluble drugs may be more effective and safe. However, developments can be challenging due to the poor flowability and feeding properties of ASDs. Consequently, this review pays special attention to these characteristics since the feeding of the components greatly influences the content uniformity in the final dosage form. The main purpose of this paper is to summarize the most important steps of the possible ASD-based continuous downstream processes in order to give a clear overview of current course lines and future perspectives.

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Linking flowability and granulometry of lactose powders

Cited by 37 publications

References 28 publications

Continuous feeding of low-dose APIs via periodic micro dosing

Continuous feeding of low-dose APIs via periodic micro dosing

Investigation of the Compressibility Characteristics of Paracetamol using “Compaction Simulator”

Continuous Formulation Approaches of Amorphous Solid Dispersions: Significance of Powder Flow Properties and Feeding Performance

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